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Protein

Sec-independent protein translocase protein TatC

Gene

tatC

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4750-MONOMER.
ECOO157:TATC-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sec-independent protein translocase protein TatCUniRule annotation
Gene namesi
Name:tatCUniRule annotation
Synonyms:mttB
Ordered Locus Names:Z5360, ECs4768
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 2322CytoplasmicSequence analysisAdd
BLAST
Transmembranei24 – 4421HelicalUniRule annotationAdd
BLAST
Topological domaini45 – 7531PeriplasmicSequence analysisAdd
BLAST
Transmembranei76 – 9621HelicalUniRule annotationAdd
BLAST
Topological domaini97 – 11519CytoplasmicSequence analysisAdd
BLAST
Transmembranei116 – 13621HelicalUniRule annotationAdd
BLAST
Topological domaini137 – 15620PeriplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalUniRule annotationAdd
BLAST
Topological domaini178 – 19215CytoplasmicSequence analysisAdd
BLAST
Transmembranei193 – 21018HelicalUniRule annotationAdd
BLAST
Topological domaini211 – 2111PeriplasmicSequence analysis
Transmembranei212 – 23221HelicalUniRule annotationAdd
BLAST
Topological domaini233 – 25826CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 258257Sec-independent protein translocase protein TatCPRO_0000098085Add
BLAST

Interactioni

Subunit structurei

The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z5360.

Structurei

3D structure databases

ProteinModelPortaliP69424.
SMRiP69424. Positions 12-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TatC family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DCX. Bacteria.
COG0805. LUCA.
HOGENOMiHOG000245379.
KOiK03118.
OMAiATQIYKF.
OrthoDBiEOG60SCQS.

Family and domain databases

HAMAPiMF_00902. TatC.
InterProiIPR019820. Sec-indep_translocase_CS.
IPR002033. TatC.
[Graphical view]
PANTHERiPTHR30371:SF0. PTHR30371:SF0. 1 hit.
PfamiPF00902. TatC. 1 hit.
[Graphical view]
PRINTSiPR01840. TATCFAMILY.
TIGRFAMsiTIGR00945. tatC. 1 hit.
PROSITEiPS01218. TATC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P69424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVEDTQPLI THLIELRKRL LNCIIAVIVI FLCLVYFAND IYHLVSAPLI
60 70 80 90 100
KQLPQGSTMI ATDVASPFFT PIKLTFMVSL ILSAPVILYQ VWAFIAPALY
110 120 130 140 150
KHERRLVVPL LVSSSLLFYI GMAFAYFVVF PLAFGFLANT APEGVQVSTD
160 170 180 190 200
IASYLSFVMA LFMAFGVSFE VPVAIVLLCW MGITSPEDLR KKRPYVLVGA
210 220 230 240 250
FVVGMLLTPP DVFSQTLLAI PMYCLFEIGV FFSRFYVGKG RNREEENDAE

AESEKTEE
Length:258
Mass (Da):28,876
Last modified:January 23, 2007 - v2
Checksum:iD2383F85AF62A81C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59034.1.
BA000007 Genomic DNA. Translation: BAB38191.1.
PIRiF86071.
H91224.
RefSeqiNP_312795.1. NC_002695.1.
WP_000109943.1. NZ_LPWC01000188.1.

Genome annotation databases

EnsemblBacteriaiAAG59034; AAG59034; Z5360.
BAB38191; BAB38191; BAB38191.
GeneIDi915136.
KEGGiece:Z5360.
ecs:ECs4768.
PATRICi18359161. VBIEscCol44059_4735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59034.1.
BA000007 Genomic DNA. Translation: BAB38191.1.
PIRiF86071.
H91224.
RefSeqiNP_312795.1. NC_002695.1.
WP_000109943.1. NZ_LPWC01000188.1.

3D structure databases

ProteinModelPortaliP69424.
SMRiP69424. Positions 12-235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z5360.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG59034; AAG59034; Z5360.
BAB38191; BAB38191; BAB38191.
GeneIDi915136.
KEGGiece:Z5360.
ecs:ECs4768.
PATRICi18359161. VBIEscCol44059_4735.

Phylogenomic databases

eggNOGiENOG4105DCX. Bacteria.
COG0805. LUCA.
HOGENOMiHOG000245379.
KOiK03118.
OMAiATQIYKF.
OrthoDBiEOG60SCQS.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4750-MONOMER.
ECOO157:TATC-MONOMER.

Family and domain databases

HAMAPiMF_00902. TatC.
InterProiIPR019820. Sec-indep_translocase_CS.
IPR002033. TatC.
[Graphical view]
PANTHERiPTHR30371:SF0. PTHR30371:SF0. 1 hit.
PfamiPF00902. TatC. 1 hit.
[Graphical view]
PRINTSiPR01840. TATCFAMILY.
TIGRFAMsiTIGR00945. tatC. 1 hit.
PROSITEiPS01218. TATC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiTATC_ECO57
AccessioniPrimary (citable) accession number: P69424
Secondary accession number(s): P27857
, P27858, P76765, P76766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.