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Protein

Multidrug resistance protein MdtH

Gene

mdtH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Confers resistance to norfloxacin and enoxacin.1 Publication

GO - Biological processi

Keywordsi

Biological processAntibiotic resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B1065-MONOMER

Protein family/group databases

TCDBi2.A.1.2.21 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtH
Gene namesi
Name:mdtH
Synonyms:yceL
Ordered Locus Names:b1065, JW1052
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13878 mdtH

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 98PeriplasmicSequence analysisAdd BLAST65
Transmembranei99 – 116HelicalSequence analysisAdd BLAST18
Topological domaini117 – 138CytoplasmicSequence analysisAdd BLAST22
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 164PeriplasmicSequence analysis5
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 213CytoplasmicSequence analysisAdd BLAST28
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 243PeriplasmicSequence analysis9
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 276CytoplasmicSequence analysisAdd BLAST12
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 299PeriplasmicSequence analysis2
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Topological domaini321 – 339CytoplasmicSequence analysisAdd BLAST19
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361 – 367PeriplasmicSequence analysis7
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 402CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001733421 – 402Multidrug resistance protein MdtHAdd BLAST402

Proteomic databases

PaxDbiP69367
PRIDEiP69367

Expressioni

Inductioni

Induced at least fivefold by indole in a dose-dependent manner.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260075, 314 interactors
IntActiP69367, 1 interactor
STRINGi316385.ECDH10B_1136

Structurei

3D structure databases

ProteinModelPortaliP69367
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EV4 Bacteria
ENOG410XSK2 LUCA
HOGENOMiHOG000266157
InParanoidiP69367
KOiK08162
OMAiMGWAALM
PhylomeDBiP69367

Family and domain databases

CDDicd06174 MFS, 1 hit
HAMAPiMF_01529 MFS_MdtH, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR022855 Multidrug-R_MdtH
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P69367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRVSQARNL GKYFLLIDNM LVVLGFFVVF PLISIRFVDQ MGWAAVMVGI
60 70 80 90 100
ALGLRQFIQQ GLGIFGGAIA DRFGAKPMIV TGMLMRAAGF ATMGIAHEPW
110 120 130 140 150
LLWFSCLLSG LGGTLFDPPR SALVVKLIRP QQRGRFFSLL MMQDSAGAVI
160 170 180 190 200
GALLGSWLLQ YDFRLVCATG AVLFVLCAAF NAWLLPAWKL STVRTPVREG
210 220 230 240 250
MTRVMRDKRF VTYVLTLAGY YMLAVQVMLM LPIMVNDVAG APSAVKWMYA
260 270 280 290 300
IEACLSLTLL YPIARWSEKH FRLEHRLMAG LLIMSLSMMP VGMVSGLQQL
310 320 330 340 350
FTLICLFYIG SIIAEPARET LSASLADARA RGSYMGFSRL GLAIGGAIGY
360 370 380 390 400
IGGGWLFDLG KSAHQPELPW MMLGIIGIFT FLALGWQFSQ KRAARRLLER

DA
Length:402
Mass (Da):44,363
Last modified:March 1, 2005 - v1
Checksum:i7220F064CD012BB4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti322 – 323SA → RS in CAA63057 (PubMed:9111025).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92076 Genomic DNA Translation: CAA63057.1
U00096 Genomic DNA Translation: AAC74149.2
AP009048 Genomic DNA Translation: BAA35873.2
PIRiF64849
RefSeqiNP_415583.4, NC_000913.3
WP_000092206.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74149; AAC74149; b1065
BAA35873; BAA35873; BAA35873
GeneIDi946920
KEGGiecj:JW1052
eco:b1065
PATRICifig|1411691.4.peg.1203

Similar proteinsi

Entry informationi

Entry nameiMDTH_ECOLI
AccessioniPrimary (citable) accession number: P69367
Secondary accession number(s): P75929, P77042, Q9R7P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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