P69330 (CITD_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Citrate lyase acyl carrier protein

Alternative name(s):
Citrate lyase gamma chain

Gene names

Name:	citD
Synonyms:	ybdX
Ordered Locus Names:	b0617, JW0609

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	98 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Covalent carrier of the coenzyme of citrate lyase. HAMAP-Rule MF_00805
Subunit structure	Oligomer with a subunit composition of (alpha,beta, gamma)6 By similarity.
Subcellular location	Cytoplasm HAMAP-Rule MF_00805.
Induction	Repressed by H-NS. Part of the citCDEFXG operon. Ref.6
Sequence similarities	Belongs to the CitD family.

Ontologies

Keywords
Cellular component	Cytoplasm
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	prosthetic group binding Inferred from direct assay PubMed 6354265. Source: EcoCyc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
glpD	P13035	1	EBI-1119230,EBI-548509

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 98	98	Citrate lyase acyl carrier protein HAMAP-Rule MF_00805		PRO_0000214695
Amino acid modifications
	Modified residue	14	1	O-(phosphoribosyl dephospho-coenzyme A)serine By similarity
Experimental info
	Sequence conflict	93 – 98	6	PWEDCQ → HGRIANDFRFAATT Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P69330 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 5932A2109978398A	FASTA	98	10,689
	10 20 30 40 50 60 MKINQPAVAG TLESGDVMIR IAPLDTQDID LQINSSVEKQ FGDAIRTTIL DVLARYNVRG 70 80 90 VQLNVDDKGA LDCILRARLE ALLARASGIP ALPWEDCQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Ingmer H., Cohen S.N. Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T. DNA Res. 3:137-155(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[5]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]	"Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux." Shimada T., Yamamoto K., Ishihama A. J. Bacteriol. 191:4562-4571(2009) [PubMed] [Europe PMC] [Abstract] Cited for: OPERON STRUCTURE, INDUCTION. Strain: K12 / BW25113.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U46667 Genomic DNA. Translation: AAC28949.1. U82598 Genomic DNA. Translation: AAB40817.1. U00096 Genomic DNA. Translation: AAC73718.1. AP009048 Genomic DNA. Translation: BAA35253.1.
PIR	G64795.
RefSeq	NP_415150.1. NC_000913.2. YP_488906.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P69330.
ModBase	Search...
Protein-protein interaction databases
IntAct	P69330. 3 interactions.
STRING	511145.b0617.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC73718; AAC73718; b0617. BAA35253; BAA35253; BAA35253.
GeneID	12930658. 945415.
KEGG	ecj:Y75_p0606. eco:b0617.
PATRIC	32116414. VBIEscCol129921_0647.
Organism-specific databases
EchoBASE	EB3313.
EcoGene	EG13543. citD.
Phylogenomic databases
eggNOG	COG3052.
HOGENOM	HOG000040480.
KO	K01646.
OMA	ESSDIMI.
ProtClustDB	PRK13253.
Enzyme and pathway databases
BioCyc	EcoCyc:ACPSUB-MONOMER. ECOL316407:JW0609-MONOMER. MetaCyc:ACPSUB-MONOMER.
Gene expression databases
Genevestigator	P69330.
Family and domain databases
HAMAP	MF_00805. CitD.
InterPro	IPR006495. CitD. IPR023439. Mal_deCO2ase/Cit_lyase_ACP. [Graphical view]
Pfam	PF06857. ACP. 1 hit. [Graphical view]
PIRSF	PIRSF002736. Citrt_lyas_gamma. 1 hit.
ProDom	PD015389. CitD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01608. citD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CITD_ECOLI

Accession

Primary (citable) accession number: P69330
Secondary accession number(s): O54336, P77618

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program