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Protein

Transcriptional regulatory protein BaeR

Gene

baeR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system BaeS/BaeR. Activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons.

GO - Molecular functioni

  1. bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding Source: EcoCyc
  2. identical protein binding Source: IntAct

GO - Biological processi

  1. phosphorelay signal transduction system Source: UniProtKB-KW
  2. positive regulation of DNA-templated transcription, initiation Source: EcoCyc
  3. regulation of response to drug Source: EcoCyc
  4. transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:BAER-MONOMER.
ECOL316407:JW2064-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein BaeR
Gene namesi
Name:baeR
Ordered Locus Names:b2079, JW2064
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11618. baeR.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Loss of induction of the casABCDE-ygbT-ygbF operon.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Transcriptional regulatory protein BaeRPRO_0000081021Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 6114-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by BaeS.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP69228.
PRIDEiP69228.

Expressioni

Gene expression databases

GenevestigatoriP69228.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-1119567,EBI-1119567

Protein-protein interaction databases

DIPiDIP-9198N.
IntActiP69228. 8 interactions.
STRINGi511145.b2079.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B09X-ray3.30A/B/C/D/E/F/G/H/I/J/K/L1-240[»]
ProteinModelPortaliP69228.
SMRiP69228. Positions 9-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 125114Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034819.
InParanoidiP69228.
KOiK07664.
OMAiLILKEVW.
OrthoDBiEOG6G4VQG.
PhylomeDBiP69228.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P69228-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELPIDENT PRILIVEDEP KLGQLLIDYL RAASYAPTLI SHGDQVLPYV
60 70 80 90 100
RQTPPDLILL DLMLPGTDGL TLCREIRRFS DIPIVMVTAK IEEIDRLLGL
110 120 130 140 150
EIGADDYICK PYSPREVVAR VKTILRRCKP QRELQQQDAE SPLIIDEGRF
160 170 180 190 200
QASWRGKMLD LTPAEFRLLK TLSHEPGKVF SREQLLNHLY DDYRVVTDRT
210 220 230 240
IDSHIKNLRR KLESLDAEQS FIRAVYGVGY RWEADACRIV
Length:240
Mass (Da):27,656
Last modified:February 14, 2005 - v1
Checksum:i8E2F6C9EB911C9CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14054 Genomic DNA. Translation: BAA03141.1.
U00096 Genomic DNA. Translation: AAC75140.1.
AP009048 Genomic DNA. Translation: BAA15935.1.
PIRiJX0283.
RefSeqiNP_416583.1. NC_000913.3.
YP_490321.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75140; AAC75140; b2079.
BAA15935; BAA15935; BAA15935.
GeneIDi12931433.
946605.
KEGGiecj:Y75_p2042.
eco:b2079.
PATRICi32119491. VBIEscCol129921_2156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14054 Genomic DNA. Translation: BAA03141.1.
U00096 Genomic DNA. Translation: AAC75140.1.
AP009048 Genomic DNA. Translation: BAA15935.1.
PIRiJX0283.
RefSeqiNP_416583.1. NC_000913.3.
YP_490321.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B09X-ray3.30A/B/C/D/E/F/G/H/I/J/K/L1-240[»]
ProteinModelPortaliP69228.
SMRiP69228. Positions 9-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-9198N.
IntActiP69228. 8 interactions.
STRINGi511145.b2079.

Proteomic databases

PaxDbiP69228.
PRIDEiP69228.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75140; AAC75140; b2079.
BAA15935; BAA15935; BAA15935.
GeneIDi12931433.
946605.
KEGGiecj:Y75_p2042.
eco:b2079.
PATRICi32119491. VBIEscCol129921_2156.

Organism-specific databases

EchoBASEiEB1575.
EcoGeneiEG11618. baeR.

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034819.
InParanoidiP69228.
KOiK07664.
OMAiLILKEVW.
OrthoDBiEOG6G4VQG.
PhylomeDBiP69228.

Enzyme and pathway databases

BioCyciEcoCyc:BAER-MONOMER.
ECOL316407:JW2064-MONOMER.

Miscellaneous databases

PROiP69228.

Gene expression databases

GenevestigatoriP69228.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel members of the two-component signal transduction genes in Escherichia coli."
    Nagasawa S., Ishige K., Mizuno T.
    J. Biochem. 114:350-357(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC."
    Nagakubo S., Nishino K., Hirata T., Yamaguchi A.
    J. Bacteriol. 184:4161-4167(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGULATION OF THE MDTABCD OPERON.
  6. "The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate."
    Baranova N., Nikaido H.
    J. Bacteriol. 184:4168-4176(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGULATION OF THE MDTABCD OPERON.
  7. "Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli."
    Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A.
    J. Biol. Chem. 280:1448-1456(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  8. "Envelope stress is a trigger of CRISPR RNA-mediated DNA silencing in Escherichia coli."
    Perez-Rodriguez R., Haitjema C., Huang Q., Nam K.H., Bernardis S., Ke A., DeLisa M.P.
    Mol. Microbiol. 79:584-599(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGULATION OF THE CASABCDE-YGBT-YGBF OPERON, DNA-BINDING, DISRUPTION PHENOTYPE.
    Strain: K12 / BW25113.

Entry informationi

Entry nameiBAER_ECOLI
AccessioniPrimary (citable) accession number: P69228
Secondary accession number(s): P30846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 14, 2005
Last sequence update: February 14, 2005
Last modified: January 6, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.