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P69228

- BAER_ECOLI

UniProt

P69228 - BAER_ECOLI

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Protein

Transcriptional regulatory protein BaeR

Gene

baeR

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system BaeS/BaeR. Activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons.

GO - Molecular functioni

  1. bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding Source: EcoCyc
  2. identical protein binding Source: IntAct

GO - Biological processi

  1. phosphorelay signal transduction system Source: UniProtKB-KW
  2. positive regulation of DNA-templated transcription, initiation Source: EcoCyc
  3. regulation of response to drug Source: EcoCyc
  4. transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:BAER-MONOMER.
ECOL316407:JW2064-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein BaeR
Gene namesi
Name:baeR
Ordered Locus Names:b2079, JW2064
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG11618. baeR.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Loss of induction of the casABCDE-ygbT-ygbF operon.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Transcriptional regulatory protein BaeRPRO_0000081021Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 6114-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by BaeS.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP69228.
PRIDEiP69228.

Expressioni

Gene expression databases

GenevestigatoriP69228.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-1119567,EBI-1119567

Protein-protein interaction databases

DIPiDIP-9198N.
IntActiP69228. 8 interactions.
STRINGi511145.b2079.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B09X-ray3.30A/B/C/D/E/F/G/H/I/J/K/L1-240[»]
ProteinModelPortaliP69228.
SMRiP69228. Positions 9-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 125114Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034819.
InParanoidiP69228.
KOiK07664.
OMAiTILRRCY.
OrthoDBiEOG6G4VQG.
PhylomeDBiP69228.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P69228-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTELPIDENT PRILIVEDEP KLGQLLIDYL RAASYAPTLI SHGDQVLPYV
60 70 80 90 100
RQTPPDLILL DLMLPGTDGL TLCREIRRFS DIPIVMVTAK IEEIDRLLGL
110 120 130 140 150
EIGADDYICK PYSPREVVAR VKTILRRCKP QRELQQQDAE SPLIIDEGRF
160 170 180 190 200
QASWRGKMLD LTPAEFRLLK TLSHEPGKVF SREQLLNHLY DDYRVVTDRT
210 220 230 240
IDSHIKNLRR KLESLDAEQS FIRAVYGVGY RWEADACRIV
Length:240
Mass (Da):27,656
Last modified:February 15, 2005 - v1
Checksum:i8E2F6C9EB911C9CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14054 Genomic DNA. Translation: BAA03141.1.
U00096 Genomic DNA. Translation: AAC75140.1.
AP009048 Genomic DNA. Translation: BAA15935.1.
PIRiJX0283.
RefSeqiNP_416583.1. NC_000913.3.
YP_490321.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75140; AAC75140; b2079.
BAA15935; BAA15935; BAA15935.
GeneIDi12931433.
946605.
KEGGiecj:Y75_p2042.
eco:b2079.
PATRICi32119491. VBIEscCol129921_2156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14054 Genomic DNA. Translation: BAA03141.1 .
U00096 Genomic DNA. Translation: AAC75140.1 .
AP009048 Genomic DNA. Translation: BAA15935.1 .
PIRi JX0283.
RefSeqi NP_416583.1. NC_000913.3.
YP_490321.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4B09 X-ray 3.30 A/B/C/D/E/F/G/H/I/J/K/L 1-240 [» ]
ProteinModelPortali P69228.
SMRi P69228. Positions 9-240.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-9198N.
IntActi P69228. 8 interactions.
STRINGi 511145.b2079.

Proteomic databases

PaxDbi P69228.
PRIDEi P69228.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75140 ; AAC75140 ; b2079 .
BAA15935 ; BAA15935 ; BAA15935 .
GeneIDi 12931433.
946605.
KEGGi ecj:Y75_p2042.
eco:b2079.
PATRICi 32119491. VBIEscCol129921_2156.

Organism-specific databases

EchoBASEi EB1575.
EcoGenei EG11618. baeR.

Phylogenomic databases

eggNOGi COG0745.
HOGENOMi HOG000034819.
InParanoidi P69228.
KOi K07664.
OMAi TILRRCY.
OrthoDBi EOG6G4VQG.
PhylomeDBi P69228.

Enzyme and pathway databases

BioCyci EcoCyc:BAER-MONOMER.
ECOL316407:JW2064-MONOMER.

Miscellaneous databases

PROi P69228.

Gene expression databases

Genevestigatori P69228.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view ]
SMARTi SM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel members of the two-component signal transduction genes in Escherichia coli."
    Nagasawa S., Ishige K., Mizuno T.
    J. Biochem. 114:350-357(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC."
    Nagakubo S., Nishino K., Hirata T., Yamaguchi A.
    J. Bacteriol. 184:4161-4167(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGULATION OF THE MDTABCD OPERON.
  6. "The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate."
    Baranova N., Nikaido H.
    J. Bacteriol. 184:4168-4176(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGULATION OF THE MDTABCD OPERON.
  7. "Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli."
    Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A.
    J. Biol. Chem. 280:1448-1456(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  8. "Envelope stress is a trigger of CRISPR RNA-mediated DNA silencing in Escherichia coli."
    Perez-Rodriguez R., Haitjema C., Huang Q., Nam K.H., Bernardis S., Ke A., DeLisa M.P.
    Mol. Microbiol. 79:584-599(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGULATION OF THE CASABCDE-YGBT-YGBF OPERON, DNA-BINDING, DISRUPTION PHENOTYPE.
    Strain: K12 / BW25113.

Entry informationi

Entry nameiBAER_ECOLI
AccessioniPrimary (citable) accession number: P69228
Secondary accession number(s): P30846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3