Transcriptional regulatory protein BaeR - Escherichia coli (strain K12)

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P69228 (BAER_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 74. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Transcriptional regulatory protein BaeR

Gene names

Name:	baeR
Ordered Locus Names:	b2079, JW2064

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Member of the two-component regulatory system BaeS/BaeR. Activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons.
Subcellular location	Cytoplasm Potential.
Post-translational modification	Phosphorylated by BaeS. Ref.7
Disruption phenotype	Loss of induction of the casABCDE-ygbT-ygbF operon. Ref.8
Sequence similarities	Contains 1 response regulatory domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Two-component regulatory system
Cellular component	Cytoplasm
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC positive regulation of DNA-dependent transcription, initiation Inferred from direct assay Ref.6. Source: EcoCyc regulation of response to drug Inferred from mutant phenotype Ref.6. Source: EcoCyc transcription, DNA-dependent Inferred from direct assay Ref.6. Source: EcoCyc
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding Inferred from direct assay Ref.6. Source: EcoCyc phosphorelay response regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 240

240

Transcriptional regulatory protein BaeR

PRO_0000081021

Regions

Domain

12 – 125

114

Response regulatory

Amino acid modifications

Modified residue

4-aspartylphosphate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P69228 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 8E2F6C9EB911C9CC
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FASTA

240

27,656

        10         20         30         40         50         60 
MTELPIDENT PRILIVEDEP KLGQLLIDYL RAASYAPTLI SHGDQVLPYV RQTPPDLILL 

        70         80         90        100        110        120 
DLMLPGTDGL TLCREIRRFS DIPIVMVTAK IEEIDRLLGL EIGADDYICK PYSPREVVAR 

       130        140        150        160        170        180 
VKTILRRCKP QRELQQQDAE SPLIIDEGRF QASWRGKMLD LTPAEFRLLK TLSHEPGKVF 

       190        200        210        220        230        240 
SREQLLNHLY DDYRVVTDRT IDSHIKNLRR KLESLDAEQS FIRAVYGVGY RWEADACRIV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel members of the two-component signal transduction genes in Escherichia coli." Nagasawa S., Ishige K., Mizuno T. J. Biochem. 114:350-357(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S. Horiuchi T. DNA Res. 3:379-392(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC." Nagakubo S., Nishino K., Hirata T., Yamaguchi A. J. Bacteriol. 184:4161-4167(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REGULATION OF THE MDTABCD OPERON.
[6]	"The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate." Baranova N., Nikaido H. J. Bacteriol. 184:4168-4176(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REGULATION OF THE MDTABCD OPERON.
[7]	"Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli." Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A. J. Biol. Chem. 280:1448-1456(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[8]	"Envelope stress is a trigger of CRISPR RNA-mediated DNA silencing in Escherichia coli." Perez-Rodriguez R., Haitjema C., Huang Q., Nam K.H., Bernardis S., Ke A., DeLisa M.P. Mol. Microbiol. 79:584-599(2011) [PubMed] [Europe PMC] [Abstract] Cited for: REGULATION OF THE CASABCDE-YGBT-YGBF OPERON, DNA-BINDING, DISRUPTION PHENOTYPE. Strain: K12 / BW25113.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D14054 Genomic DNA. Translation: BAA03141.1. U00096 Genomic DNA. Translation: AAC75140.1. AP009048 Genomic DNA. Translation: BAA15935.1.
PIR	JX0283.
RefSeq	NP_416583.1. NC_000913.2. YP_490321.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P69228.
SMR	P69228. Positions 7-232.
ModBase	Search...
Protein-protein interaction databases
IntAct	P69228. 6 interactions.
STRING	511145.b2079.
Proteomic databases
PaxDb	P69228.
PRIDE	P69228.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC75140; AAC75140; b2079. BAA15935; BAA15935; BAA15935.
GeneID	12931433. 946605.
KEGG	ecj:Y75_p2042. eco:b2079.
PATRIC	32119491. VBIEscCol129921_2156.
Organism-specific databases
EchoBASE	EB1575.
EcoGene	EG11618. baeR.
Phylogenomic databases
eggNOG	COG0745.
HOGENOM	HOG000034819.
KO	K07664.
OMA	EADACRM.
ProtClustDB	PRK10710.
Enzyme and pathway databases
BioCyc	EcoCyc:BAER-MONOMER. ECOL316407:JW2064-MONOMER.
Gene expression databases
Genevestigator	P69228.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR011006. CheY-like_superfamily. IPR001867. Sig_transdc_resp-reg_C. IPR016032. Sig_transdc_resp-reg_C-effctor. IPR001789. Sig_transdc_resp-reg_receiver. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00072. Response_reg. 1 hit. PF00486. Trans_reg_C. 1 hit. [Graphical view]
SMART	SM00448. REC. 1 hit. SM00862. Trans_reg_C. 1 hit. [Graphical view]
SUPFAM	SSF46894. Bipartite_resp_reg_C-effector. 1 hit. SSF52172. CheY_like. 1 hit.
PROSITE	PS50110. RESPONSE_REGULATORY. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BAER_ECOLI

Accession

Primary (citable) accession number: P69228
Secondary accession number(s): P30846

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents