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Protein

Transcriptional regulatory protein BaeR

Gene

baeR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress (PubMed:12354228). Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression (PubMed:12354228). Activates the mdtABCD (PubMed:12107133, PubMed:12107134) and probably the CRISPR-Cas casABCDE-ygbT-ygbF operon (PubMed:21255106).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi131 – 234OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST104

GO - Molecular functioni

GO - Biological processi

  • phosphorelay signal transduction system Source: UniProtKB-KW
  • positive regulation of DNA-templated transcription, initiation Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • regulation of response to drug Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Stress response, Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:BAER-MONOMER.
ECOL316407:JW2064-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein BaeR
Gene namesi
Name:baeR1 Publication
Ordered Locus Names:b2079, JW2064
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11618. baeR.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Increased sensitivity to membrane stress caused by indole or by overexpression of P pili protein PapG; double baeR-cpxR mutants are more sensitive yet (PubMed:12354228). Loss of induction of the CRISPR-Cas casABCDE-ygbT-ygbF operon (PubMed:21255106).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000810211 – 240Transcriptional regulatory protein BaeRAdd BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei614-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by BaeS.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP69228.
PRIDEiP69228.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-1119567,EBI-1119567

Protein-protein interaction databases

BioGridi4260427. 6 interactors.
DIPiDIP-9198N.
IntActiP69228. 8 interactors.
STRINGi511145.b2079.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B09X-ray3.30A/B/C/D/E/F/G/H/I/J/K/L1-240[»]
ProteinModelPortaliP69228.
SMRiP69228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 125Response regulatoryPROSITE-ProRule annotationAdd BLAST114

Sequence similaritiesi

Contains 1 OmpR/PhoB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105E3W. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034819.
InParanoidiP69228.
KOiK07664.
OMAiYQASYLG.
PhylomeDBiP69228.

Family and domain databases

CDDicd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P69228-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELPIDENT PRILIVEDEP KLGQLLIDYL RAASYAPTLI SHGDQVLPYV
60 70 80 90 100
RQTPPDLILL DLMLPGTDGL TLCREIRRFS DIPIVMVTAK IEEIDRLLGL
110 120 130 140 150
EIGADDYICK PYSPREVVAR VKTILRRCKP QRELQQQDAE SPLIIDEGRF
160 170 180 190 200
QASWRGKMLD LTPAEFRLLK TLSHEPGKVF SREQLLNHLY DDYRVVTDRT
210 220 230 240
IDSHIKNLRR KLESLDAEQS FIRAVYGVGY RWEADACRIV
Length:240
Mass (Da):27,656
Last modified:February 15, 2005 - v1
Checksum:i8E2F6C9EB911C9CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14054 Genomic DNA. Translation: BAA03141.1.
U00096 Genomic DNA. Translation: AAC75140.1.
AP009048 Genomic DNA. Translation: BAA15935.1.
PIRiJX0283.
RefSeqiNP_416583.1. NC_000913.3.
WP_000137877.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75140; AAC75140; b2079.
BAA15935; BAA15935; BAA15935.
GeneIDi946605.
KEGGiecj:JW2064.
eco:b2079.
PATRICi32119491. VBIEscCol129921_2156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14054 Genomic DNA. Translation: BAA03141.1.
U00096 Genomic DNA. Translation: AAC75140.1.
AP009048 Genomic DNA. Translation: BAA15935.1.
PIRiJX0283.
RefSeqiNP_416583.1. NC_000913.3.
WP_000137877.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B09X-ray3.30A/B/C/D/E/F/G/H/I/J/K/L1-240[»]
ProteinModelPortaliP69228.
SMRiP69228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260427. 6 interactors.
DIPiDIP-9198N.
IntActiP69228. 8 interactors.
STRINGi511145.b2079.

Proteomic databases

PaxDbiP69228.
PRIDEiP69228.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75140; AAC75140; b2079.
BAA15935; BAA15935; BAA15935.
GeneIDi946605.
KEGGiecj:JW2064.
eco:b2079.
PATRICi32119491. VBIEscCol129921_2156.

Organism-specific databases

EchoBASEiEB1575.
EcoGeneiEG11618. baeR.

Phylogenomic databases

eggNOGiENOG4105E3W. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034819.
InParanoidiP69228.
KOiK07664.
OMAiYQASYLG.
PhylomeDBiP69228.

Enzyme and pathway databases

BioCyciEcoCyc:BAER-MONOMER.
ECOL316407:JW2064-MONOMER.

Miscellaneous databases

PROiP69228.

Family and domain databases

CDDicd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBAER_ECOLI
AccessioniPrimary (citable) accession number: P69228
Secondary accession number(s): P30846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.