P69216 (COX3_BRAFL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:

COIII

Encoded on

Mitochondrion

Organism

Branchiostoma floridae (Florida lancelet) (Amphioxus) [Reference proteome]

Taxonomic identifier

7739 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Cephalochordata › Branchiostomidae › Branchiostoma

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Cytochrome c oxidase subunit 3		PRO_0000183747
Regions
	Transmembrane	11 – 31	21	Helical; Potential
	Transmembrane	32 – 52	21	Helical; Potential
	Transmembrane	83 – 103	21	Helical; Potential
	Transmembrane	125 – 147	23	Helical; Potential
	Transmembrane	160 – 180	21	Helical; Potential
	Transmembrane	198 – 218	21	Helical; Potential
	Transmembrane	240 – 260	21	Helical; Potential
Natural variations
	Natural variant	6	1	P → S in strain: Bf-H09. Ref.1
	Natural variant	52	1	V → I in strain: Bf-M01 and Bf-H10. Ref.1
	Natural variant	160	1	A → V in strain: Bf-H07. Ref.1
	Natural variant	210	1	I → V in strain: Bf-H03 and Bf-H04. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P69216 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 6D93D8338AC870D8	FASTA	262	29,711
	10 20 30 40 50 60 MTGYQPHPWH LVEPSPWPLV GGSAAFTLTV GLVMWFHYNS ISLMILGLVM IVATMIQWWR 70 80 90 100 110 120 DVIREATFQG CHTSYVLSGL RRGMVLFIVS EVFFFLAFFW AFFHSSLAPT VELGVTWPPV 130 140 150 160 170 180 GVHPLNAFAV PLLNTAVLLS SGVTVTWAHH ALMEGKRTEA IQSLAITVML GLYFTGLQAW 190 200 210 220 230 240 EYYEAPFTIA DSVYGSTFFV ATGFHGLHVI IGSTFLMVCL GRQVFYHYTS SHHFGFEAAA 250 260 WYWHFVDVVW LFLYVCIYWW GS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Branchiostoma mitochondrial DNA, complete genome." Takada Y., Imai T. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-6; ILE-52; VAL-160 AND VAL-210. Strain: Bf-H01, Bf-H02, Bf-H03, Bf-H04, Bf-H05, Bf-H06, Bf-H07, Bf-H08, Bf-H09, Bf-H10, Bf-M01, Bf-M02, Bf-M03, Bf-M04, Bf-M05, Bf-M06, Bf-M07, Bf-M08, Bf-M09 and Bf-M10.
[2]	"Complete sequence, gene arrangement, and genetic code of mitochondrial DNA of the cephalochordate Branchiostoma floridae (Amphioxus)." Boore J.L., Daehler L.L., Brown W.M. Mol. Biol. Evol. 16:410-418(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB478574 Genomic DNA. Translation: BAH86333.1. AB478575 Genomic DNA. Translation: BAH86346.1. AB478576 Genomic DNA. Translation: BAH86359.1. AB478577 Genomic DNA. Translation: BAH86372.1. AB478578 Genomic DNA. Translation: BAH86385.1. AB478579 Genomic DNA. Translation: BAH86398.1. AB478580 Genomic DNA. Translation: BAH86411.1. AB478581 Genomic DNA. Translation: BAH86424.1. AB478582 Genomic DNA. Translation: BAH86437.1. AB478583 Genomic DNA. Translation: BAH86450.1. AB478584 Genomic DNA. Translation: BAH86463.1. AB478585 Genomic DNA. Translation: BAH86476.1. AB478586 Genomic DNA. Translation: BAH86489.1. AB478587 Genomic DNA. Translation: BAH86502.1. AB478588 Genomic DNA. Translation: BAH86515.1. AB478589 Genomic DNA. Translation: BAH86528.1. AB478590 Genomic DNA. Translation: BAH86541.1. AB478591 Genomic DNA. Translation: BAH86554.1. AB478592 Genomic DNA. Translation: BAH86567.1. AB478593 Genomic DNA. Translation: BAH86580.1. AF098298 Genomic DNA. Translation: AAB87994.1.
RefSeq	NP_007761.1. NC_000834.1.
3D structure databases
ProteinModelPortal	P69216.
SMR	P69216. Positions 4-262.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	808730.
KEGG	bfo:COX3.
Organism-specific databases
CTD	4514.
Phylogenomic databases
HOVERGEN	HBG016686.
KO	K02262.
ProtClustDB	MTH00189.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_BRAFL

Accession

Primary (citable) accession number: P69216
Secondary accession number(s): C6L3C4 , C6L3D7, C6L3L5, C6L3Q4, C6L3Z5, C6L408, O47425

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	February 15, 2005
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program