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P69216 (COX3_BRAFL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:COIII
Encoded onMitochondrion
OrganismBranchiostoma floridae (Florida lancelet) (Amphioxus) [Reference proteome]
Taxonomic identifier7739 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Cytochrome c oxidase subunit 3
PRO_0000183747

Regions

Transmembrane11 – 3121Helical; Potential
Transmembrane32 – 5221Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane125 – 14723Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane198 – 21821Helical; Potential
Transmembrane240 – 26021Helical; Potential

Natural variations

Natural variant61P → S in strain: Bf-H09. Ref.1
Natural variant521V → I in strain: Bf-M01 and Bf-H10. Ref.1
Natural variant1601A → V in strain: Bf-H07. Ref.1
Natural variant2101I → V in strain: Bf-H03 and Bf-H04. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P69216 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 6D93D8338AC870D8

FASTA26229,711
        10         20         30         40         50         60 
MTGYQPHPWH LVEPSPWPLV GGSAAFTLTV GLVMWFHYNS ISLMILGLVM IVATMIQWWR 

        70         80         90        100        110        120 
DVIREATFQG CHTSYVLSGL RRGMVLFIVS EVFFFLAFFW AFFHSSLAPT VELGVTWPPV 

       130        140        150        160        170        180 
GVHPLNAFAV PLLNTAVLLS SGVTVTWAHH ALMEGKRTEA IQSLAITVML GLYFTGLQAW 

       190        200        210        220        230        240 
EYYEAPFTIA DSVYGSTFFV ATGFHGLHVI IGSTFLMVCL GRQVFYHYTS SHHFGFEAAA 

       250        260 
WYWHFVDVVW LFLYVCIYWW GS 

« Hide

References

« Hide 'large scale' references
[1]"Branchiostoma mitochondrial DNA, complete genome."
Takada Y., Imai T.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-6; ILE-52; VAL-160 AND VAL-210.
Strain: Bf-H01, Bf-H02, Bf-H03, Bf-H04, Bf-H05, Bf-H06, Bf-H07, Bf-H08, Bf-H09, Bf-H10, Bf-M01, Bf-M02, Bf-M03, Bf-M04, Bf-M05, Bf-M06, Bf-M07, Bf-M08, Bf-M09 and Bf-M10.
[2]"Complete sequence, gene arrangement, and genetic code of mitochondrial DNA of the cephalochordate Branchiostoma floridae (Amphioxus)."
Boore J.L., Daehler L.L., Brown W.M.
Mol. Biol. Evol. 16:410-418(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB478574 Genomic DNA. Translation: BAH86333.1.
AB478575 Genomic DNA. Translation: BAH86346.1.
AB478576 Genomic DNA. Translation: BAH86359.1.
AB478577 Genomic DNA. Translation: BAH86372.1.
AB478578 Genomic DNA. Translation: BAH86385.1.
AB478579 Genomic DNA. Translation: BAH86398.1.
AB478580 Genomic DNA. Translation: BAH86411.1.
AB478581 Genomic DNA. Translation: BAH86424.1.
AB478582 Genomic DNA. Translation: BAH86437.1.
AB478583 Genomic DNA. Translation: BAH86450.1.
AB478584 Genomic DNA. Translation: BAH86463.1.
AB478585 Genomic DNA. Translation: BAH86476.1.
AB478586 Genomic DNA. Translation: BAH86489.1.
AB478587 Genomic DNA. Translation: BAH86502.1.
AB478588 Genomic DNA. Translation: BAH86515.1.
AB478589 Genomic DNA. Translation: BAH86528.1.
AB478590 Genomic DNA. Translation: BAH86541.1.
AB478591 Genomic DNA. Translation: BAH86554.1.
AB478592 Genomic DNA. Translation: BAH86567.1.
AB478593 Genomic DNA. Translation: BAH86580.1.
AF098298 Genomic DNA. Translation: AAB87994.1.
RefSeqNP_007761.1. NC_000834.1.

3D structure databases

ProteinModelPortalP69216.
SMRP69216. Positions 4-262.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808730.
KEGGbfo:COX3.

Organism-specific databases

CTD4514.

Phylogenomic databases

HOVERGENHBG016686.
KOK02262.
ProtClustDBMTH00189.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_BRAFL
AccessionPrimary (citable) accession number: P69216
Secondary accession number(s): C6L3C4 expand/collapse secondary AC list , C6L3D7, C6L3L5, C6L3Q4, C6L3Z5, C6L408, O47425
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families