Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Spermidine export protein MdtJ

Gene

mdtJ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS.2 Publications

GO - Molecular functioni

GO - Biological processi

  • glycine betaine transport Source: GO_Central
  • spermidine transmembrane transport Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:B1600-MONOMER
MetaCyc:B1600-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Spermidine export protein MdtJ
Gene namesi
Name:mdtJ
Synonyms:ydgF
Ordered Locus Names:b1600, JW1592
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13927 mdtJ

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1CytoplasmicSequence analysis1
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Topological domaini23 – 31PeriplasmicSequence analysis9
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 54CytoplasmicSequence analysis2
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 81PeriplasmicSequence analysis6
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 121CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi4Y → L: Decrease in spermidine excretion. 1 Publication1
Mutagenesisi5W → L: Decrease in spermidine excretion. 1 Publication1
Mutagenesisi15E → Q: Decrease in spermidine excretion. 1 Publication1
Mutagenesisi45Y → L: Decrease in spermidine excretion. 1 Publication1
Mutagenesisi61Y → L: Decrease in spermidine excretion. 1 Publication1
Mutagenesisi82E → Q: Decrease in spermidine excretion. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001080791 – 121Spermidine export protein MdtJAdd BLAST121

Proteomic databases

PaxDbiP69212
PRIDEiP69212

Expressioni

Inductioni

Induced by spermidine.1 Publication

Interactioni

Subunit structurei

Forms a complex with MdtI.1 Publication

Protein-protein interaction databases

BioGridi4260838, 195 interactors
STRINGi316385.ECDH10B_1733

Structurei

3D structure databases

ProteinModelPortaliP69212
SMRiP69212
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41090TI Bacteria
COG2076 LUCA
HOGENOMiHOG000268006
InParanoidiP69212
KOiK11743
OMAiMKLAATH
PhylomeDBiP69212

Family and domain databases

HAMAPiMF_01598 MdtJ, 1 hit
InterProiView protein in InterPro
IPR000390 Small_multidrug_res
IPR023740 Spermidine_export_MdtJ
PANTHERiPTHR30561:SF2 PTHR30561:SF2, 1 hit
PfamiView protein in Pfam
PF00893 Multi_Drug_Res, 1 hit

Sequencei

Sequence statusi: Complete.

P69212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYIYWILLGL AIATEITGTL SMKWASVSEG NGGFILMLVM ISLSYIFLSF
60 70 80 90 100
AVKKIALGVA YALWEGIGIL FITLFSVLLF DESLSLMKIA GLTTLVAGIV
110 120
LIKSGTRKAR KPELEVNHGA V
Length:121
Mass (Da):13,115
Last modified:February 15, 2005 - v1
Checksum:iB24330AF5BB181B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74672.1
AP009048 Genomic DNA Translation: BAA15334.1
PIRiB64916
RefSeqiNP_416117.1, NC_000913.3
WP_000276149.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74672; AAC74672; b1600
BAA15334; BAA15334; BAA15334
GeneIDi946139
KEGGiecj:JW1592
eco:b1600
PATRICifig|1411691.4.peg.662

Similar proteinsi

Entry informationi

Entry nameiMDTJ_ECOLI
AccessioniPrimary (citable) accession number: P69212
Secondary accession number(s): P77412
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health