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Protein

Spermidine export protein MdtI

Gene

mdtI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS.2 Publications

GO - Molecular functioni

GO - Biological processi

  • glycine betaine transport Source: GO_Central
  • spermidine transmembrane transport Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:B1599-MONOMER
MetaCyc:B1599-MONOMER

Protein family/group databases

TCDBi2.A.7.1.9 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Spermidine export protein MdtI
Gene namesi
Name:mdtI
Synonyms:ydgE
Ordered Locus Names:b1599, JW1591
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13926 mdtI

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5PeriplasmicSequence analysis5
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Topological domaini27 – 35CytoplasmicSequence analysis9
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 63PeriplasmicSequence analysis7
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 87CytoplasmicSequence analysis3
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109PeriplasmicSequence analysis1

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoliWiki

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5E → Q: Decrease in spermidine excretion. 1 Publication1
Mutagenesisi19E → Q: Decrease in spermidine excretion. 1 Publication1
Mutagenesisi60D → N: Decrease in spermidine excretion. 1 Publication1
Mutagenesisi68W → L: Decrease in spermidine excretion. 1 Publication1
Mutagenesisi81W → L: Decrease in spermidine excretion. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001080751 – 109Spermidine export protein MdtIAdd BLAST109

Proteomic databases

PaxDbiP69210
PRIDEiP69210

Expressioni

Inductioni

Induced by spermidine.1 Publication

Interactioni

Subunit structurei

Forms a complex with MdtJ.1 Publication

Protein-protein interaction databases

BioGridi4259124, 494 interactors
IntActiP69210, 1 interactor
STRINGi316385.ECDH10B_1732

Structurei

3D structure databases

ProteinModelPortaliP69210
SMRiP69210
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ZBZ Bacteria
COG2076 LUCA
HOGENOMiHOG000268006
InParanoidiP69210
KOiK11742
OMAiVAAGWIM
PhylomeDBiP69210

Family and domain databases

HAMAPiMF_01597 MdtI, 1 hit
InterProiView protein in InterPro
IPR000390 Small_multidrug_res
IPR023737 Spermidine_export_MdtI
PANTHERiPTHR30561:SF6 PTHR30561:SF6, 1 hit
PfamiView protein in Pfam
PF00893 Multi_Drug_Res, 1 hit

Sequencei

Sequence statusi: Complete.

P69210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFEWVHAA WLALAIVLEI VANVFLKFSD GFRRKIFGLL SLAAVLAAFS
60 70 80 90 100
ALSQAVKGID LSVAYALWGG FGIAATLAAG WILFGQRLNR KGWIGLVLLL

AGMIMVKLA
Length:109
Mass (Da):11,720
Last modified:February 15, 2005 - v1
Checksum:iBBDF61985CB7AE97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74671.1
AP009048 Genomic DNA Translation: BAA15333.1
PIRiA64916
RefSeqiNP_416116.1, NC_000913.3
WP_000046661.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74671; AAC74671; b1599
BAA15333; BAA15333; BAA15333
GeneIDi947333
KEGGiecj:JW1591
eco:b1599
PATRICifig|1411691.4.peg.663

Similar proteinsi

Entry informationi

Entry nameiMDTI_ECOLI
AccessioniPrimary (citable) accession number: P69210
Secondary accession number(s): P77670
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health