Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Spermidine export protein MdtI

Gene

mdtI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS.2 Publications

GO - Molecular functioni

  • spermidine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • spermidine transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:B1599-MONOMER.
ECOL316407:JW1591-MONOMER.
MetaCyc:B1599-MONOMER.

Protein family/group databases

TCDBi2.A.7.1.9. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Spermidine export protein MdtI
Gene namesi
Name:mdtI
Synonyms:ydgE
Ordered Locus Names:b1599, JW1591
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13926. mdtI.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5PeriplasmicSequence analysis5
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Topological domaini27 – 35CytoplasmicSequence analysis9
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 63PeriplasmicSequence analysis7
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 87CytoplasmicSequence analysis3
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109PeriplasmicSequence analysis1

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoliWiki
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5E → Q: Decrease in spermidine excretion. 1 Publication1
Mutagenesisi19E → Q: Decrease in spermidine excretion. 1 Publication1
Mutagenesisi60D → N: Decrease in spermidine excretion. 1 Publication1
Mutagenesisi68W → L: Decrease in spermidine excretion. 1 Publication1
Mutagenesisi81W → L: Decrease in spermidine excretion. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001080751 – 109Spermidine export protein MdtIAdd BLAST109

Proteomic databases

PaxDbiP69210.
PRIDEiP69210.

Expressioni

Inductioni

Induced by spermidine.1 Publication

Interactioni

Subunit structurei

Forms a complex with MdtJ.1 Publication

Protein-protein interaction databases

BioGridi4259124. 494 interactors.
IntActiP69210. 1 interactor.
STRINGi511145.b1599.

Structurei

3D structure databases

ProteinModelPortaliP69210.
SMRiP69210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ZBZ. Bacteria.
COG2076. LUCA.
HOGENOMiHOG000268006.
InParanoidiP69210.
KOiK11742.
OMAiFRRKFYG.
PhylomeDBiP69210.

Family and domain databases

HAMAPiMF_01597. MdtI. 1 hit.
InterProiIPR000390. Small_multidrug_res.
IPR023737. Spermidine_export_MdtI.
[Graphical view]
PANTHERiPTHR30561:SF6. PTHR30561:SF6. 1 hit.
PfamiPF00893. Multi_Drug_Res. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P69210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFEWVHAA WLALAIVLEI VANVFLKFSD GFRRKIFGLL SLAAVLAAFS
60 70 80 90 100
ALSQAVKGID LSVAYALWGG FGIAATLAAG WILFGQRLNR KGWIGLVLLL

AGMIMVKLA
Length:109
Mass (Da):11,720
Last modified:February 15, 2005 - v1
Checksum:iBBDF61985CB7AE97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74671.1.
AP009048 Genomic DNA. Translation: BAA15333.1.
PIRiA64916.
RefSeqiNP_416116.1. NC_000913.3.
WP_000046661.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74671; AAC74671; b1599.
BAA15333; BAA15333; BAA15333.
GeneIDi947333.
KEGGiecj:JW1591.
eco:b1599.
PATRICi32118500. VBIEscCol129921_1670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74671.1.
AP009048 Genomic DNA. Translation: BAA15333.1.
PIRiA64916.
RefSeqiNP_416116.1. NC_000913.3.
WP_000046661.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP69210.
SMRiP69210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259124. 494 interactors.
IntActiP69210. 1 interactor.
STRINGi511145.b1599.

Protein family/group databases

TCDBi2.A.7.1.9. the drug/metabolite transporter (dmt) superfamily.

Proteomic databases

PaxDbiP69210.
PRIDEiP69210.

Protocols and materials databases

DNASUi947333.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74671; AAC74671; b1599.
BAA15333; BAA15333; BAA15333.
GeneIDi947333.
KEGGiecj:JW1591.
eco:b1599.
PATRICi32118500. VBIEscCol129921_1670.

Organism-specific databases

EchoBASEiEB3685.
EcoGeneiEG13926. mdtI.

Phylogenomic databases

eggNOGiENOG4108ZBZ. Bacteria.
COG2076. LUCA.
HOGENOMiHOG000268006.
InParanoidiP69210.
KOiK11742.
OMAiFRRKFYG.
PhylomeDBiP69210.

Enzyme and pathway databases

BioCyciEcoCyc:B1599-MONOMER.
ECOL316407:JW1591-MONOMER.
MetaCyc:B1599-MONOMER.

Miscellaneous databases

PROiP69210.

Family and domain databases

HAMAPiMF_01597. MdtI. 1 hit.
InterProiIPR000390. Small_multidrug_res.
IPR023737. Spermidine_export_MdtI.
[Graphical view]
PANTHERiPTHR30561:SF6. PTHR30561:SF6. 1 hit.
PfamiPF00893. Multi_Drug_Res. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDTI_ECOLI
AccessioniPrimary (citable) accession number: P69210
Secondary accession number(s): P77670
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.