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Protein

Repressor protein C2

Gene

C2

Organism
Enterobacteria phage P22 (Bacteriophage P22)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein allows the phage to reside inactively in the chromosome of its host bacterium. This lysogenic state is maintained by binding of regulatory protein C2 to the OR and OL operators, preventing transcription of proteins necessary for lytic development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi21 – 4020H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Protein family/group databases

MEROPSiS24.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Repressor protein C2
Gene namesi
Name:C2
OrganismiEnterobacteria phage P22 (Bacteriophage P22)
Taxonomic identifieri10754 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeP22likevirus
Virus hostiSalmonella typhimurium [TaxID: 90371]
Proteomesi
  • UP000001795 Componenti: Genome
  • UP000007960 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Repressor protein C2PRO_0000149717Add
BLAST

Post-translational modificationi

In the mature form of the repressor protein the initiator methionine is deformylated.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei1 – 11Not N-formylated

Structurei

Secondary structure

1
216
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1712Combined sources
Helixi21 – 288Combined sources
Helixi32 – 398Combined sources
Helixi47 – 5610Combined sources
Helixi61 – 666Combined sources
Turni73 – 753Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ADRNMR-A1-76[»]
1QARmodel-C/D1-216[»]
2R1JX-ray1.53L/R1-68[»]
3JXBX-ray1.67C/D2-68[»]
3JXCX-ray1.90L/R2-68[»]
3JXDX-ray2.10L/R2-68[»]
ProteinModelPortaliP69202.
SMRiP69202. Positions 1-76, 119-212.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP69202.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 6455HTH cro/C1-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH cro/C1-type DNA-binding domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
2.10.109.10. 1 hit.
InterProiIPR001387. Cro/C1-type_HTH.
IPR010982. Lambda_DNA-bd_dom.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view]
PfamiPF01381. HTH_3. 1 hit.
PF00717. Peptidase_S24. 1 hit.
[Graphical view]
SMARTiSM00530. HTH_XRE. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF51306. SSF51306. 1 hit.
PROSITEiPS50943. HTH_CROC1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P69202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTQLMGERI RARRKKLKIR QAALGKMVGV SNVAISQWER SETEPNGENL
60 70 80 90 100
LALSKALQCS PDYLLKGDLS QTNVAYHSRH EPRGSYPLIS WVSAGQWMEA
110 120 130 140 150
VEPYHKRAIE NWHDTTVDCS EDSFWLDVQG DSMTAPAGLS IPEGMIILVD
160 170 180 190 200
PEVEPRNGKL VVAKLEGENE ATFKKLVMDA GRKFLKPLNP QYPMIEINGN
210
CKIIGVVVDA KLANLP
Length:216
Mass (Da):24,069
Last modified:July 21, 1986 - v1
Checksum:i85A32EE9DB785E09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01153 Genomic DNA. Translation: CAA24470.1.
AF217253 Genomic DNA. Translation: AAF75024.1.
BK000583 Genomic DNA. Translation: DAA01021.1.
PIRiA03571. RPBP22.
RefSeqiNP_059606.1. NC_002371.2.

Genome annotation databases

GeneIDi1262793.
KEGGivg:1262793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01153 Genomic DNA. Translation: CAA24470.1.
AF217253 Genomic DNA. Translation: AAF75024.1.
BK000583 Genomic DNA. Translation: DAA01021.1.
PIRiA03571. RPBP22.
RefSeqiNP_059606.1. NC_002371.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ADRNMR-A1-76[»]
1QARmodel-C/D1-216[»]
2R1JX-ray1.53L/R1-68[»]
3JXBX-ray1.67C/D2-68[»]
3JXCX-ray1.90L/R2-68[»]
3JXDX-ray2.10L/R2-68[»]
ProteinModelPortaliP69202.
SMRiP69202. Positions 1-76, 119-212.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS24.002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1262793.
KEGGivg:1262793.

Miscellaneous databases

EvolutionaryTraceiP69202.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
2.10.109.10. 1 hit.
InterProiIPR001387. Cro/C1-type_HTH.
IPR010982. Lambda_DNA-bd_dom.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view]
PfamiPF01381. HTH_3. 1 hit.
PF00717. Peptidase_S24. 1 hit.
[Graphical view]
SMARTiSM00530. HTH_XRE. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF51306. SSF51306. 1 hit.
PROSITEiPS50943. HTH_CROC1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the phage P22 repressor and its gene c2."
    Sauer R.T., Pan J., Hopper P., Hehir K., Brown J., Poteete A.R.
    Biochemistry 20:3591-3598(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE.
  2. "Sequence of the genome of Salmonella bacteriophage P22."
    Vander Byl C.S., Kropinski A.M.B.
    J. Bacteriol. 182:6472-6481(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Operator sequences of bacteriophages P22 and 21."
    Poteete A.R., Ptashne M., Ballivet M., Eisen H.
    J. Mol. Biol. 137:81-91(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5.
  5. "Determination of the nuclear magnetic resonance structure of the DNA-binding domain of the P22 c2 repressor (1 to 76) in solution and comparison with the DNA-binding domain of the 434 repressor."
    Sevilla-Sierra P., Otting G., Wuethrich K.
    J. Mol. Biol. 235:1003-1020(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-76.

Entry informationi

Entry nameiRPC2_BPP22
AccessioniPrimary (citable) accession number: P69202
Secondary accession number(s): P03035, Q7PCF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 14, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.