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Protein

Serine-repeat antigen protein

Gene

SERA

Organism
Plasmodium falciparum (isolate CDC / Honduras)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

It may function at the red blood cell membrane, perhaps as a component that influences the invasion process.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei588 – 5881Ancestral active site
Active sitei754 – 7541By similarity
Active sitei779 – 7791By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-repeat antigen protein
Alternative name(s):
111 kDa antigen
p126
Gene namesi
Name:SERA
OrganismiPlasmodium falciparum (isolate CDC / Honduras)
Taxonomic identifieri5836 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Subcellular locationi

  • Vacuole

  • Note: Exported antigen that accumulates in the parasitophorous vacuole.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Vacuole

Pathology & Biotechi

Keywords - Diseasei

Malaria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 989973Serine-repeat antigen proteinPRO_0000026480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence analysis
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence analysis
Glycosylationi820 – 8201N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Contains numerous possible O-linked glycosylation and serine phosphorylation sites.

Keywords - PTMi

Glycoprotein

Structurei

Secondary structure

1
989
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni556 – 5583Combined sources
Beta strandi559 – 5624Combined sources
Helixi566 – 5683Combined sources
Helixi574 – 5763Combined sources
Helixi588 – 60316Combined sources
Helixi613 – 6186Combined sources
Beta strandi621 – 6233Combined sources
Turni627 – 6293Combined sources
Helixi634 – 64411Combined sources
Turni650 – 6523Combined sources
Helixi657 – 6593Combined sources
Turni674 – 6774Combined sources
Beta strandi686 – 6883Combined sources
Beta strandi693 – 6997Combined sources
Helixi700 – 7034Combined sources
Helixi707 – 72115Combined sources
Beta strandi724 – 7285Combined sources
Helixi730 – 7334Combined sources
Helixi736 – 7394Combined sources
Beta strandi740 – 7445Combined sources
Beta strandi754 – 76512Combined sources
Beta strandi771 – 7788Combined sources
Beta strandi790 – 7967Combined sources
Beta strandi808 – 8125Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WBFX-ray1.60X555-819[»]
ProteinModelPortaliP69193.
SMRiP69193. Positions 556-820.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP69193.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni571 – 989419Thiol-protease-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 227201Ser-richAdd
BLAST
Compositional biasi191 – 22535Poly-SerAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 2 hits.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P69193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSYISLFFI LCVIFNKNVI KCTGESQTGN TGGGQAGNTV GDQAGSTGGS
60 70 80 90 100
PQGSTGASQP GSSEPSNPVS SGHSVSTVSV SQTSTSSEKQ DTIQVKSALL
110 120 130 140 150
KDYMGLKVTG PCNENFIMFL VPHIYIDVDT EDTNIELRTT LKETNNAISF
160 170 180 190 200
ESNSGSLEKK KYVKLPSNGT TGEQGSSTGT VRGDTEPISD SSSSSSSSSS
210 220 230 240 250
SSSSSSSSSS SSSSSSSSSS SSSSSESLPA NGPDSPTVKP PRNLQNICET
260 270 280 290 300
GKNFKLVVYI KENTLIIKWK VYGETKDTTE NNKVDVRKYL INEKETPFTS
310 320 330 340 350
ILIHAYKEHN GTNLIESKNY ALGSDIPEKC DTLASNCFLS GNFNIEKCFQ
360 370 380 390 400
CALLVEKENK NDVCYKYLSE DIVSNFKEIK AETEDDDEDD YTEYKLTESI
410 420 430 440 450
DNILVKMFKT NENNDKSELI KLEEVDDSLK LELMNYCSLL KDVDTTGTLD
460 470 480 490 500
NYGMGNEMDI FNNLKRLLIY HSEENINTLK NKFRNAAVCL KNVDDWIVNK
510 520 530 540 550
RGLVLPELNY DLEYFNEHLY NDKNSPEDKD NKGKGVVHVD TTLEKEDTLS
560 570 580 590 600
YDNSDNMFCN KEYCNRLKDE NNCISNLQVE DQGNCDTSWI FASKYHLETI
610 620 630 640 650
RCMKGYEPTK ISALYVANCY KGEHKDRCDE GSSPMEFLQI IEDYGFLPAE
660 670 680 690 700
SNYPYNYVKV GEQCPKVEDH WMNLWDNGKI LHNKNEPNSL DGKGYTAYES
710 720 730 740 750
ERFHDNMDAF VKIIKTEVMN KGSVIAYIKA ENVMGYEFSG KKVQNLCGDD
760 770 780 790 800
TADHAVNIVG YGNYVNSEGE KKSYWIVRNS WGPYWGDEGY FKVDMYGPTH
810 820 830 840 850
CHFNFIHSVV IFNVDLPMNN KTTKKESKIY DYYLKASPEF YHNLYFKNFN
860 870 880 890 900
VGKKNLFSEK EDNENNKKLG NNYIIFGQDT AGSGQSGKES NTALESAGTS
910 920 930 940 950
NEVSERVHVY HILKHIKDGK IRMGMRKYID TQDVNKKHSC TRSYAFNPEN
960 970 980
YEKCVNLCNV NWKTCEEKTS PGLCLSKLDT NNECYFCYV
Length:989
Mass (Da):111,095
Last modified:February 15, 2005 - v1
Checksum:iE732960770C15F52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08113 Genomic DNA. Translation: AAA74911.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08113 Genomic DNA. Translation: AAA74911.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WBFX-ray1.60X555-819[»]
ProteinModelPortaliP69193.
SMRiP69193. Positions 556-820.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP69193.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 2 hits.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSERA_PLAFD
AccessioniPrimary (citable) accession number: P69193
Secondary accession number(s): P13823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: November 11, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.