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Protein

Thymidine kinase

Gene

TK

Organism
Equine herpesvirus 1 (strain HVS25A) (EHV-1) (Equine abortion virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601Proton acceptorSequence Analysis
Binding sitei78 – 781SubstrateBy similarity
Binding sitei102 – 1021SubstrateBy similarity
Binding sitei148 – 1481SubstrateBy similarity
Binding sitei192 – 1921ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 398ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
OrganismiEquine herpesvirus 1 (strain HVS25A) (EHV-1) (Equine abortion virus)
Taxonomic identifieri10327 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Thymidine kinasePRO_0000175065Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP69186.
SMRiP69186. Positions 23-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P69186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARVPSGEA RRSASGAPVR RQVTIVRIYL DGVYGIGKST TGRVMASAAS
60 70 80 90 100
GGSPTLYFPE PMAYWRTLFE ADVISGIYDT QNRKQQGDLA ADDAASITAH
110 120 130 140 150
YQSRFTTPYL ILHDHTFGLF GGDSLQRGTR PDLTVVFDRH PVASAVCFPA
160 170 180 190 200
ARYLIGDMSM CALIAMVATL PREPQGGNIV VTTLNVDEHV RRLRTRARIG
210 220 230 240 250
EQIDMKLIAT LRNVYSMLAN TSNFLRSGRV WRDGWGELPL SCETYKHRAT
260 270 280 290 300
QMDAFQERES PELSDTLFAM FKTPELLDDR GVILEVHAWA LDALMLKLRN
310 320 330 340 350
LSVFCADLSG TPRQCAATVE SLIPLMSSTL SDSESASSLE RAARTFNAEM

GV
Length:352
Mass (Da):38,750
Last modified:February 14, 2005 - v1
Checksum:i66EF05158DD3B3F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13209 Genomic DNA. Translation: CAA31599.1.
PIRiS01995. KIBED2.
RefSeqiYP_053084.1. NC_001491.2.

Genome annotation databases

GeneIDi1487533.
KEGGivg:1487533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13209 Genomic DNA. Translation: CAA31599.1.
PIRiS01995. KIBED2.
RefSeqiYP_053084.1. NC_001491.2.

3D structure databases

ProteinModelPortaliP69186.
SMRiP69186. Positions 23-352.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1487533.
KEGGivg:1487533.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Evolution of the herpes thymidine kinase: identification and comparison of the equine herpesvirus 1 thymidine kinase gene reveals similarity to a cell-encoded thymidylate kinase."
    Robertson G.R., Whalley J.M.
    Nucleic Acids Res. 16:11303-11317(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKITH_EHV1
AccessioniPrimary (citable) accession number: P69186
Secondary accession number(s): P09100, P28856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 14, 2005
Last sequence update: February 14, 2005
Last modified: March 31, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.