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P69185

- KITH_EHV1B

UniProt

P69185 - KITH_EHV1B

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Protein
Thymidine kinase
Gene
TK, 38
Organism
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601Proton acceptor Reviewed prediction
Binding sitei78 – 781Substrate By similarity
Binding sitei102 – 1021Substrate By similarity
Binding sitei148 – 1481Substrate By similarity
Binding sitei192 – 1921ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 398ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
Synonyms:38
OrganismiEquine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Taxonomic identifieri31520 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
ProteomesiUP000001189: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Thymidine kinase
PRO_0000175066Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP69185.
SMRiP69185. Positions 23-352.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P69185-1 [UniParc]FASTAAdd to Basket

« Hide

MAARVPSGEA RRSASGAPVR RQVTIVRIYL DGVYGIGKST TGRVMASAAS    50
GGSPTLYFPE PMAYWRTLFE ADVISGIYDT QNRKQQGDLA ADDAASITAH 100
YQSRFTTPYL ILHDHTFGLF GGDSLQRGTR PDLTVVFDRH PVASAVCFPA 150
ARYLIGDMSM CALIAMVATL PREPQGGNIV VTTLNVDEHV RRLRTRARIG 200
EQIDMKLIAT LRNVYSMLAN TSNFLRSGRV WRDGWGELPL SCETYKHRAT 250
QMDAFQERES PELSDTLFAM FKTPELLDDR GVILEVHAWA LDALMLKLRN 300
LSVFCADLSG TPRQCAATVE SLIPLMSSTL SDSESASSLE RAARTFNAEM 350
GV 352
Length:352
Mass (Da):38,750
Last modified:February 15, 2005 - v1
Checksum:i66EF05158DD3B3F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY665713 Genomic DNA. Translation: AAT67296.1.
X67961 Genomic DNA. Translation: CAA48144.1.
PIRiS01995. KIBED2.
RefSeqiYP_053084.1. NC_001491.2.

Genome annotation databases

GeneIDi1487533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY665713 Genomic DNA. Translation: AAT67296.1 .
X67961 Genomic DNA. Translation: CAA48144.1 .
PIRi S01995. KIBED2.
RefSeqi YP_053084.1. NC_001491.2.

3D structure databases

ProteinModelPortali P69185.
SMRi P69185. Positions 23-352.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1487533.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00693. Herpes_TK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Sequence analysis of thymidine kinase-defective mutants of equine herpesvirus-1 (EHV-1)."
    Corrochano L.M., Madueno F., Field H.J., de la Fuente R.
    Gene 126:257-260(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKITH_EHV1B
AccessioniPrimary (citable) accession number: P69185
Secondary accession number(s): P09100, P28856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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