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P69185

- KITH_EHV1B

UniProt

P69185 - KITH_EHV1B

Protein

Thymidine kinase

Gene

TK

Organism
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei60 – 601Proton acceptorSequence Analysis
    Binding sitei78 – 781SubstrateBy similarity
    Binding sitei102 – 1021SubstrateBy similarity
    Binding sitei148 – 1481SubstrateBy similarity
    Binding sitei192 – 1921ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi32 – 398ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    Synonyms:38
    OrganismiEquine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
    Taxonomic identifieri31520 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
    Virus hostiEquus caballus (Horse) [TaxID: 9796]
    ProteomesiUP000001189: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 352352Thymidine kinasePRO_0000175066Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP69185.
    SMRiP69185. Positions 23-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P69185-1 [UniParc]FASTAAdd to Basket

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    MAARVPSGEA RRSASGAPVR RQVTIVRIYL DGVYGIGKST TGRVMASAAS    50
    GGSPTLYFPE PMAYWRTLFE ADVISGIYDT QNRKQQGDLA ADDAASITAH 100
    YQSRFTTPYL ILHDHTFGLF GGDSLQRGTR PDLTVVFDRH PVASAVCFPA 150
    ARYLIGDMSM CALIAMVATL PREPQGGNIV VTTLNVDEHV RRLRTRARIG 200
    EQIDMKLIAT LRNVYSMLAN TSNFLRSGRV WRDGWGELPL SCETYKHRAT 250
    QMDAFQERES PELSDTLFAM FKTPELLDDR GVILEVHAWA LDALMLKLRN 300
    LSVFCADLSG TPRQCAATVE SLIPLMSSTL SDSESASSLE RAARTFNAEM 350
    GV 352
    Length:352
    Mass (Da):38,750
    Last modified:February 15, 2005 - v1
    Checksum:i66EF05158DD3B3F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY665713 Genomic DNA. Translation: AAT67296.1.
    X67961 Genomic DNA. Translation: CAA48144.1.
    PIRiS01995. KIBED2.
    RefSeqiYP_053084.1. NC_001491.2.

    Genome annotation databases

    GeneIDi1487533.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY665713 Genomic DNA. Translation: AAT67296.1 .
    X67961 Genomic DNA. Translation: CAA48144.1 .
    PIRi S01995. KIBED2.
    RefSeqi YP_053084.1. NC_001491.2.

    3D structure databases

    ProteinModelPortali P69185.
    SMRi P69185. Positions 23-352.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1487533.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Sequence analysis of thymidine kinase-defective mutants of equine herpesvirus-1 (EHV-1)."
      Corrochano L.M., Madueno F., Field H.J., de la Fuente R.
      Gene 126:257-260(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_EHV1B
    AccessioniPrimary (citable) accession number: P69185
    Secondary accession number(s): P09100, P28856
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3