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Protein

Thymidine kinase

Gene

TK

Organism
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.UniRule annotation

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei60Proton acceptorUniRule annotation1
Binding sitei78SubstrateUniRule annotation1
Binding sitei102SubstrateUniRule annotation1
Binding sitei192ATPUniRule annotation1
Binding sitei198SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:TKUniRule annotation
Ordered Locus Names:38
OrganismiEquine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Taxonomic identifieri31520 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Proteomesi
  • UP000001189 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001750661 – 352Thymidine kinaseAdd BLAST352

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP69185
SMRiP69185
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae thymidine kinase family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900004C

Family and domain databases

HAMAPiMF_04029 HSV_KITH, 1 hit
InterProiView protein in InterPro
IPR001889 Herpes_TK
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00693 Herpes_TK, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

P69185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARVPSGEA RRSASGAPVR RQVTIVRIYL DGVYGIGKST TGRVMASAAS
60 70 80 90 100
GGSPTLYFPE PMAYWRTLFE ADVISGIYDT QNRKQQGDLA ADDAASITAH
110 120 130 140 150
YQSRFTTPYL ILHDHTFGLF GGDSLQRGTR PDLTVVFDRH PVASAVCFPA
160 170 180 190 200
ARYLIGDMSM CALIAMVATL PREPQGGNIV VTTLNVDEHV RRLRTRARIG
210 220 230 240 250
EQIDMKLIAT LRNVYSMLAN TSNFLRSGRV WRDGWGELPL SCETYKHRAT
260 270 280 290 300
QMDAFQERES PELSDTLFAM FKTPELLDDR GVILEVHAWA LDALMLKLRN
310 320 330 340 350
LSVFCADLSG TPRQCAATVE SLIPLMSSTL SDSESASSLE RAARTFNAEM

GV
Length:352
Mass (Da):38,750
Last modified:February 15, 2005 - v1
Checksum:i66EF05158DD3B3F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665713 Genomic DNA Translation: AAT67296.1
X67961 Genomic DNA Translation: CAA48144.1
PIRiS01995 KIBED2
RefSeqiYP_053084.1, NC_001491.2

Genome annotation databases

GeneIDi1487533
KEGGivg:1487533

Similar proteinsi

Entry informationi

Entry nameiKITH_EHV1B
AccessioniPrimary (citable) accession number: P69185
Secondary accession number(s): P09100, P28856
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: April 25, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health