P69148 (FMRF_HELTI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: FMRFamide
Organism	Helisoma trivolvis (Snail)
Taxonomic identifier	283763 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Mollusca › Gastropoda › Heterobranchia › Euthyneura › Panpulmonata › Hygrophila › Planorboidea › Planorbidae › Planorbella

Protein attributes

Sequence length	4 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Myoactive; cardioexcitatory substance. Pharmacological activities include augmentation, induction, and regularization of cardiac contraction.
Subcellular location	Secreted.
Sequence similarities	Belongs to the FARP (FMRFamide related peptide) family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Neuropeptide
PTM	Amidation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 4	4	FMRFamide		PRO_0000043647
Amino acid modifications
	Modified residue	4	1	Phenylalanine amide

Sequences

	Sequence		Length	Mass (Da)
	P69148 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 69D40699A0000000	FASTA	4	600
	FMRF

References

[1]	"FMRFamide-related peptides from the kidney of the snail, Helisoma trivolvis." Madrid K.P., Price D.A., Greenberg M.J., Khan H.R., Saleuddin A.S.M. Peptides 15:31-36(1994) [PubMed: 7912428] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Kidney.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

FMRF_HELTI

Accession

Primary (citable) accession number: P69148
Secondary accession number(s): P01162

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 5, 2011
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)