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Protein

Succinate dehydrogenase cytochrome b556 subunit

Gene

sdhC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Membrane-anchoring subunit of succinate dehydrogenase (SDH).

Miscellaneous

His-84 provides an axial ligand to heme b556 in the wild-type enzyme. The retention of low spin heme b556 in the SdhC 'Leu-84' mutant suggests that swapping of the heme axial ligand by His-91 or His-30 is possible.

Cofactori

hemeNote: The heme is bound between the two transmembrane subunits.

Pathwayi: tricarboxylic acid cycle

This protein is involved in the pathway tricarboxylic acid cycle, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Iron (heme axial ligand); shared with second transmembrane subunit1

GO - Molecular functioni

  • electron transfer activity Source: EcoCyc
  • heme binding Source: EcoCyc
  • metal ion binding Source: UniProtKB-KW
  • succinate dehydrogenase (ubiquinone) activity Source: EcoliWiki
  • ubiquinone binding Source: EcoliWiki

GO - Biological processi

  • aerobic respiration Source: EcoCyc
  • cytochrome complex assembly Source: EcoCyc
  • tricarboxylic acid cycle Source: UniProtKB-UniPathway

Keywordsi

Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:SDH-MEMB1
MetaCyc:SDH-MEMB1
UniPathwayiUPA00223

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase cytochrome b556 subunit
Short name:
Cytochrome b-556
Gene namesi
Name:sdhC
Synonyms:cybA
Ordered Locus Names:b0721, JW0711
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10933 sdhC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26Cytoplasmic1 PublicationAdd BLAST26
Transmembranei27 – 52HelicalAdd BLAST26
Topological domaini53 – 68Periplasmic1 PublicationAdd BLAST16
Transmembranei69 – 89HelicalAdd BLAST21
Topological domaini90 – 108Cytoplasmic1 PublicationAdd BLAST19
Transmembranei109 – 129HelicalAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB04631 Atpenin A5
DB08690 UBIQUINONE-2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002035101 – 129Succinate dehydrogenase cytochrome b556 subunitAdd BLAST129

Proteomic databases

PaxDbiP69054
PRIDEiP69054

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.3 Publications

Protein-protein interaction databases

BioGridi4259942, 36 interactors
DIPiDIP-10837N
IntActiP69054, 4 interactors
STRINGi316385.ECDH10B_0788

Structurei

Secondary structure

1129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 17Combined sources3
Helixi22 – 52Combined sources31
Helixi55 – 66Combined sources12
Helixi68 – 95Combined sources28
Helixi103 – 126Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NEKX-ray2.60C1-129[»]
1NENX-ray2.90C1-129[»]
2ACZX-ray3.10C1-129[»]
2AD0model-C1-129[»]
2WDQX-ray2.40C/G/K1-129[»]
2WDRX-ray3.20C/G/K1-129[»]
2WDVX-ray3.20C/G/K1-129[»]
2WP9X-ray2.70C/G/K1-129[»]
2WS3X-ray3.20C/G/K1-129[»]
2WU2X-ray2.50C/G/K1-129[»]
2WU5X-ray2.80C/G/K1-129[»]
ProteinModelPortaliP69054
SMRiP69054
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP69054

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b560 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108UTY Bacteria
COG2009 LUCA
HOGENOMiHOG000160252
InParanoidiP69054
KOiK00241
OMAiYHLVAGI
PhylomeDBiP69054

Family and domain databases

Gene3Di1.20.1300.10, 1 hit
InterProiView protein in InterPro
IPR034804 SQR/QFR_C/D
IPR018495 Succ_DH_cyt_bsu_CS
IPR014314 Succ_DH_cytb556
IPR000701 SuccDH_FuR_B_TM-su
PfamiView protein in Pfam
PF01127 Sdh_cyt, 1 hit
PIRSFiPIRSF000178 SDH_cyt_b560, 1 hit
SUPFAMiSSF81343 SSF81343, 1 hit
TIGRFAMsiTIGR02970 succ_dehyd_cytB, 1 hit
PROSITEiView protein in PROSITE
PS01000 SDH_CYT_1, 1 hit
PS01001 SDH_CYT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P69054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRNVKKQRP VNLDLQTIRF PITAIASILH RVSGVITFVA VGILLWLLGT
60 70 80 90 100
SLSSPEGFEQ ASAIMGSFFV KFIMWGILTA LAYHVVVGIR HMMMDFGYLE
110 120
ETFEAGKRSA KISFVITVVL SLLAGVLVW
Length:129
Mass (Da):14,299
Last modified:February 1, 2005 - v1
Checksum:i57485D25D2535818
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01619 Genomic DNA Translation: AAA23893.1
M28989 Genomic DNA Translation: AAA24616.1
X00980 Genomic DNA Translation: CAA25485.1
U00096 Genomic DNA Translation: AAC73815.1
AP009048 Genomic DNA Translation: BAA35388.1
PIRiA28836 DEECS4
RefSeqiNP_415249.1, NC_000913.3
WP_001308496.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73815; AAC73815; b0721
BAA35388; BAA35388; BAA35388
GeneIDi945316
KEGGiecj:JW0711
eco:b0721
PATRICifig|511145.12.peg.751

Similar proteinsi

Entry informationi

Entry nameiDHSC_ECOLI
AccessioniPrimary (citable) accession number: P69054
Secondary accession number(s): P10446
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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