Reviewed, UniProtKB/Swiss-Prot P69053 (LLY_LEGPC)

Names and origin

Protein names

Recommended name:
    4-hydroxyphenylpyruvate dioxygenase
      Short name=HPPDase
      Short name=4HPPD
      Short name=HPD
    EC=1.13.11.27
Alternative name(s):
    Legiolysin

Gene names

Name:	lly
Ordered Locus Names:	LPC_1747

Organism

Legionella pneumophila (strain Corby) [Complete proteome] [HAMAP]

Taxonomic identifier

400673 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the transformation of p-hydroxyphenylpyruvate into HGA. Has hemolytic and brown pigment production activity.
Catalytic activity	4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2).
Cofactor	Binds 1 iron ion per subunit By similarity.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Cytolysis Hemolysis
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase Toxin
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family metabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW hemolysis by symbiont of host red blood cells Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	4-hydroxyphenylpyruvate dioxygenase		PRO_0000088413
Sites
	Metal binding	154	1	Iron By similarity
	Metal binding	232	1	Iron By similarity
	Metal binding	312	1	Iron By similarity
Experimental info
	Sequence conflict	94	1	I → S in CAA04693. Ref.1
	Sequence conflict	141	1	S → P in CAA04693. Ref.1
	Sequence conflict	348	1	T → S in CAA04693. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P69053-1 [UniParc]. Last modified October 2, 2007. Version 2. Checksum: F25DE43DDCD749E3	FASTA	348	38,927
	10 20 30 40 50 60 MQNNNPCGLD GFAFLEFSGP DRNKLHQQFS EMGFQAVAHH KNQDITLFKQ GEIQFIVNAA 70 80 90 100 110 120 SHCQAEAHAS THGPGACAMG FKVKDAKAAF QHAIAHGGIA FQDAPHANHG LPAIQAIGGS 130 140 150 160 170 180 VIYFVDEEHQ PFSHEWNITS SEPVVGNGLT AIDHLTHNVY RGNMDKWASF YASIFNFQEI 190 200 210 220 230 240 RFFNIKGKMT GLVSRALGSP CGKIKIPLNE SKDDLSQIEE FLHEYHGEGI QHIALNTNDI 250 260 270 280 290 300 YKTVNGLRKQ GVKFLDVPDT YYEMINDRLP WHKEPLNQLH AEKILIDGEA DPKDGLLLQI 310 320 330 340 FTENIFGPVF FEIIQRKGNQ GFGEGNFQAL FEAIERDQVR RGTLKELT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Lly protein is essential for p-hydroxyphenylpyruvate dioxygenase activity in Legionella pneumophila." Steinert M., Flugel M., Schuppler M., Helbig J.H., Supriyono A., Proksch P., Lueck P.C. FEMS Microbiol. Lett. 203:41-47(2001) [PubMed: 11557138] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]	"Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island." Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ001357 Genomic DNA. Translation: CAA04693.1. CP000675 Genomic DNA. Translation: ABQ55683.1.
RefSeq	YP_001251029.1.
3D structure databases
HSSP	HSSP built from PDB template 1CJX based on UniProtKB P80064.
ModBase	Search...
Genome annotation databases
GeneID	5181555.
GenomeReviews	Gene locus LPC_1747 in contig CP000675_GR.
KEGG	lpc:LPC_1747.
Organism-specific databases
CMR	Search...
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_bleo-R_dOase. [Graphical view]
Pfam	PF00903. Glyoxalase. 1 hit. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LLY_LEGPC

Accession

Primary (citable) accession number: P69053
Secondary accession number(s): A5IE83, Q53407

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 2, 2007
Last modified:	November 25, 2008
This is version 22 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)