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P69040

- IF5A1_TOBAC

UniProt

P69040 - IF5A1_TOBAC

Protein

Eukaryotic translation initiation factor 5A-1

Gene

EIF-5A1

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond.

    GO - Molecular functioni

    1. ribosome binding Source: InterPro
    2. translation elongation factor activity Source: InterPro
    3. translation initiation factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. peptidyl-lysine modification to peptidyl-hypusine Source: InterPro
    2. positive regulation of translational elongation Source: InterPro
    3. positive regulation of translational termination Source: InterPro
    4. translational frameshifting Source: InterPro

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 5A-1
    Short name:
    eIF-5A-1
    Alternative name(s):
    eIF-4D
    Gene namesi
    Name:EIF-5A1
    OrganismiNicotiana tabacum (Common tobacco)
    Taxonomic identifieri4097 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 159159Eukaryotic translation initiation factor 5A-1PRO_0000142482Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei52 – 521HypusineBy similarity

    Post-translational modificationi

    eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

    Keywords - PTMi

    Hypusine

    Structurei

    3D structure databases

    ProteinModelPortaliP69040.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eIF-5A family.Curated

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    2.40.50.140. 1 hit.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR014722. Rib_L2_dom2.
    IPR019769. Trans_elong_IF5A_hypusine_site.
    IPR001884. Transl_elong_IF5A.
    IPR020189. Transl_elong_IF5A_C.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR11673. PTHR11673. 1 hit.
    PfamiPF01287. eIF-5a. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003025. eIF5A. 1 hit.
    SUPFAMiSSF50104. SSF50104. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
    PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P69040-1 [UniParc]FASTAAdd to Basket

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    MSDEEHHFES KADAGASKTY PQQAGTIRKN GHIVIKNRPC KVVEVSTSKT    50
    GKHGHAKCHF VAIDIFTGKK LEDIVPSSHN CDVPHVNRTD YQLIDISEDG 100
    FVSLLTENGN TKDDLRLPTD DNLLALIKDG FAEGKDLVLS VMSAMGEEQI 150
    CGIKDVGPK 159
    Length:159
    Mass (Da):17,371
    Last modified:February 1, 2005 - v1
    Checksum:i5174BC5809E8E275
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63543 Genomic DNA. Translation: CAA45105.1.
    PIRiS21060.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63543 Genomic DNA. Translation: CAA45105.1 .
    PIRi S21060.

    3D structure databases

    ProteinModelPortali P69040.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    2.40.50.140. 1 hit.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR014722. Rib_L2_dom2.
    IPR019769. Trans_elong_IF5A_hypusine_site.
    IPR001884. Transl_elong_IF5A.
    IPR020189. Transl_elong_IF5A_C.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR11673. PTHR11673. 1 hit.
    Pfami PF01287. eIF-5a. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003025. eIF5A. 1 hit.
    SUPFAMi SSF50104. SSF50104. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00037. eIF_5A. 1 hit.
    PROSITEi PS00302. IF5A_HYPUSINE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential expression of genes encoding the hypusine-containing translation initiation factor, eIF-5A, in tobacco."
      Chamot D., Kuhlemeter C.
      Nucleic Acids Res. 20:665-669(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Leaf.

    Entry informationi

    Entry nameiIF5A1_TOBAC
    AccessioniPrimary (citable) accession number: P69040
    Secondary accession number(s): P24921
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are at least two genes for eIF-5A in tobacco: 5A1 may regulate the light-dependent translation of specific transcripts while 5A2 may be a housekeeping protein.

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3