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P69040

- IF5A1_TOBAC

UniProt

P69040 - IF5A1_TOBAC

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Protein

Eukaryotic translation initiation factor 5A-1

Gene
EIF-5A1
Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond.

GO - Molecular functioni

  1. ribosome binding Source: InterPro
  2. translation elongation factor activity Source: InterPro
  3. translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. peptidyl-lysine modification to peptidyl-hypusine Source: InterPro
  2. positive regulation of translational elongation Source: InterPro
  3. positive regulation of translational termination Source: InterPro
  4. translational frameshifting Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 5A-1
Short name:
eIF-5A-1
Alternative name(s):
eIF-4D
Gene namesi
Name:EIF-5A1
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Eukaryotic translation initiation factor 5A-1PRO_0000142482Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521Hypusine By similarity

Post-translational modificationi

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

Keywords - PTMi

Hypusine

Structurei

3D structure databases

ProteinModelPortaliP69040.

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiPF01287. eIF-5a. 1 hit.
[Graphical view]
PIRSFiPIRSF003025. eIF5A. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P69040-1 [UniParc]FASTAAdd to Basket

« Hide

MSDEEHHFES KADAGASKTY PQQAGTIRKN GHIVIKNRPC KVVEVSTSKT    50
GKHGHAKCHF VAIDIFTGKK LEDIVPSSHN CDVPHVNRTD YQLIDISEDG 100
FVSLLTENGN TKDDLRLPTD DNLLALIKDG FAEGKDLVLS VMSAMGEEQI 150
CGIKDVGPK 159
Length:159
Mass (Da):17,371
Last modified:February 1, 2005 - v1
Checksum:i5174BC5809E8E275
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63543 Genomic DNA. Translation: CAA45105.1.
PIRiS21060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63543 Genomic DNA. Translation: CAA45105.1 .
PIRi S21060.

3D structure databases

ProteinModelPortali P69040.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
PANTHERi PTHR11673. PTHR11673. 1 hit.
Pfami PF01287. eIF-5a. 1 hit.
[Graphical view ]
PIRSFi PIRSF003025. eIF5A. 1 hit.
SUPFAMi SSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00037. eIF_5A. 1 hit.
PROSITEi PS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Differential expression of genes encoding the hypusine-containing translation initiation factor, eIF-5A, in tobacco."
    Chamot D., Kuhlemeter C.
    Nucleic Acids Res. 20:665-669(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Leaf.

Entry informationi

Entry nameiIF5A1_TOBAC
AccessioniPrimary (citable) accession number: P69040
Secondary accession number(s): P24921
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

There are at least two genes for eIF-5A in tobacco: 5A1 may regulate the light-dependent translation of specific transcripts while 5A2 may be a housekeeping protein.

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi