Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P69040 (IF5A1_TOBAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 5A-1

Short name=eIF-5A-1
Alternative name(s):
eIF-4D
Gene names
Name:EIF-5A1
OrganismNicotiana tabacum (Common tobacco)
Taxonomic identifier4097 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond.

Post-translational modification

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

Miscellaneous

There are at least two genes for eIF-5A in tobacco: 5A1 may regulate the light-dependent translation of specific transcripts while 5A2 may be a housekeeping protein.

Sequence similarities

Belongs to the eIF-5A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 159159Eukaryotic translation initiation factor 5A-1
PRO_0000142482

Amino acid modifications

Modified residue521Hypusine By similarity

Sequences

Sequence LengthMass (Da)Tools
P69040 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 5174BC5809E8E275

FASTA15917,371
        10         20         30         40         50         60 
MSDEEHHFES KADAGASKTY PQQAGTIRKN GHIVIKNRPC KVVEVSTSKT GKHGHAKCHF 

        70         80         90        100        110        120 
VAIDIFTGKK LEDIVPSSHN CDVPHVNRTD YQLIDISEDG FVSLLTENGN TKDDLRLPTD 

       130        140        150 
DNLLALIKDG FAEGKDLVLS VMSAMGEEQI CGIKDVGPK 

« Hide

References

[1]"Differential expression of genes encoding the hypusine-containing translation initiation factor, eIF-5A, in tobacco."
Chamot D., Kuhlemeter C.
Nucleic Acids Res. 20:665-669(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63543 Genomic DNA. Translation: CAA45105.1.
PIRS21060.

3D structure databases

ProteinModelPortalP69040.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
InterProIPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERPTHR11673. PTHR11673. 1 hit.
PfamPF01287. eIF-5a. 1 hit.
[Graphical view]
PIRSFPIRSF003025. eIF5A. 1 hit.
SUPFAMSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00037. eIF_5A. 1 hit.
PROSITEPS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF5A1_TOBAC
AccessionPrimary (citable) accession number: P69040
Secondary accession number(s): P24921
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries