P68982 (SPIKE_ADE09) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fiber protein
Short name=SPIKE

Alternative name(s):
Protein IV

Gene names

ORF Names:

L5

Organism

Human adenovirus D serotype 9 (HAdV-9) (Human adenovirus 9)

Taxonomic identifier

10527 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus D

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CXCAR to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface By similarity.
Subunit structure	Homotrimer. Interacts with host receptor CXCAR. Interacts (via N-terminal tail region) with pentons By similarity.
Subcellular location	Virion By similarity. Host nucleus By similarity. Note: Anchored to the pentons, protrudes from the virion surface By similarity.
Induction	Expressed in the late phase of the viral replicative cycle.
Domain	The tail region anchors the fiber to penton base capsomers, whereas the shaft, built from several repeated motifs, allows the knob to protrude from the virion By similarity.
Miscellaneous	All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell By similarity.
Sequence similarities	Belongs to the adenoviridae fiber family.

Ontologies

Keywords
Biological process	Host-virus interaction Viral attachment to host cell Virus entry into host cell
Cellular component	Host nucleus Virion
Developmental stage	Late protein
Molecular function	Capsid protein
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: InterPro pathogenesis Inferred from electronic annotation. Source: InterPro viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW viral infectious cycle Inferred from electronic annotation. Source: InterPro
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Fiber protein		PRO_0000221792

Sequences

	Sequence		Length	Mass (Da)
	P68982 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 2662E5546A9C4DA0	FASTA	362	39,420
	10 20 30 40 50 60 MSKRLRVEDD FNPVYPYGYA RNQNIPFLTP PFVSSDGFQN FPPGVLSLKL ADPIAIVNGN 70 80 90 100 110 120 VSLKVGGGLT LQDGTGKLTV NADPPLQLTN NKLGIALDAP FDVIDNKLTL LAGHGLSIIT 130 140 150 160 170 180 KETSTLPGLR NTLVVLTGKG IGTESTDNGG TVCVRVGEGG GLSFNNDGDL VAFNKKEDKR 190 200 210 220 230 240 TLWTTPDTSP NCKIDQDKDS KLTLVLTKCG SQILANVSLI VVDGKYKIIN NNTQPALKGF 250 260 270 280 290 300 TIKLLFDENG VLMESSNLGK SYWNFRNENS IMSTAYEKAI GFMPNLVAYP KPTAGSKKYA 310 320 330 340 350 360 RDIVYGNIYL GGKPDQPVTI KTTFNQETGC EYSITFDFSW AKTYVNVEFE TTSFTFSYIA QE

References

[1]	"Characterization of adenovirus subgenus D fiber genes." Pring-Akerblom P., Adrian T. Virology 206:564-571(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate ATCC VR-1086 / Hicks / V-209-003-014.
[2]	"Adenovirus receptors." Zhang Y., Bergelson J.M. J. Virol. 79:12125-12131(2005) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X74659 Genomic DNA. Translation: CAA52723.1.
PIR	S37220.
3D structure databases
ProteinModelPortal	P68982.
SMR	P68982. Positions 178-362.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.10.25.20. 2 hits. 2.60.90.10. 1 hit.
InterPro	IPR000931. Adeno_fibre. IPR000978. Adeno_fibre_knob. IPR000939. Adenobir_fibre_prot_rpt/shaft. IPR008982. Adenovirus_pIV-rel_att. IPR009013. Attachment_protein_shaft_dom. [Graphical view]
Pfam	PF00541. Adeno_knob. 1 hit. PF00608. Adeno_shaft. 2 hits. [Graphical view]
PRINTS	PR00307. ADENOVSFIBRE.
SUPFAM	SSF49835. Viral_att. 1 hit. SSF51225. Viral_att_shaft. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SPIKE_ADE09

Accession

Primary (citable) accession number: P68982
Secondary accession number(s): P36846

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program