Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P68979

- E3GL_ADE06

UniProt

P68979 - E3GL_ADE06

Protein

Early E3 18.5 kDa glycoprotein

Gene
N/A
Organism
Human adenovirus C serotype 6 (HAdV-6) (Human adenovirus 6)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds and retains class I heavy chains in the endoplasmic reticulum during the early period of virus infection, thereby impairing their transport to the cell surface. Also delays the expression of class I alleles that it cannot affect by direct retention. Binds transporters associated with antigen processing (TAP) and acts as a tapasin inhibitor, preventing class I/TAP association. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes By similarity.By similarity

    GO - Molecular functioni

    1. mannose binding Source: UniProtKB-KW

    GO - Biological processi

    1. suppression by virus of host adaptive immune response Source: UniProtKB-KW
    2. suppression by virus of host tapasin activity Source: UniProtKB

    Keywords - Biological processi

    Host-virus interaction, Inhibition of host adaptive immune response by virus, Inhibition of host tapasin by virus, Viral immunoevasion

    Keywords - Ligandi

    Lectin, Mannose-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Early E3 18.5 kDa glycoprotein
    Alternative name(s):
    E3-19K
    E3gp 19 kDa
    Short name:
    E19
    GP19K
    OrganismiHuman adenovirus C serotype 6 (HAdV-6) (Human adenovirus 6)
    Taxonomic identifieri10534 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717By similarityAdd
    BLAST
    Chaini18 – 159142Early E3 18.5 kDa glycoproteinPRO_0000036485Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi28 ↔ 45By similarity
    Glycosylationi29 – 291N-linked (GlcNAc...); by hostSequence Analysis
    Disulfide bondi39 ↔ 100By similarity
    Glycosylationi78 – 781N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Both disulfide bonds are absolutely critical for the interaction with MHC antigens.By similarity
    N-glycosylated; high-mannose.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Developmental stagei

    Expressed at early period of virus infection.

    Keywords - Developmental stagei

    Early protein

    Structurei

    Secondary structure

    1
    159
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 359
    Beta strandi38 – 469
    Beta strandi48 – 569
    Beta strandi59 – 6911
    Beta strandi76 – 838
    Beta strandi86 – 938
    Helixi96 – 1038
    Helixi105 – 1095

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4E5XX-ray1.95G/H18-117[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 123106LumenalSequence AnalysisAdd
    BLAST
    Topological domaini145 – 15915CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi156 – 1594Di-lysine motifBy similarity

    Domaini

    The lumenal domain binds directly to the peptide-binding domain of class I molecules.
    The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

    Sequence similaritiesi

    Belongs to the adenoviridae E19 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR006965. Adenovirus_Gp19K.
    [Graphical view]
    PfamiPF04881. Adeno_GP19K. 1 hit.
    [Graphical view]
    ProDomiPD006739. Adeno_GP19K. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P68979-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRYMILGLLA LAAVCSAAKK VEFKEPACNV TFKSEANECT TLIKCTTEHE    50
    KLIIRHKDKI GKYAVYAIWQ PGDTNDYNVT VFQGENRKTF MYKFPFYEMC 100
    DITMYMSKQY KLWPPQKCLE NTGTFCSTAL LITALALVCT LLYLKYKSRR 150
    SFIDEKKMP 159
    Length:159
    Mass (Da):18,438
    Last modified:July 21, 1986 - v1
    Checksum:iED2519547E18AEB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16037 Genomic DNA. Translation: CAA75990.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16037 Genomic DNA. Translation: CAA75990.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4E5X X-ray 1.95 G/H 18-117 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR006965. Adenovirus_Gp19K.
    [Graphical view ]
    Pfami PF04881. Adeno_GP19K. 1 hit.
    [Graphical view ]
    ProDomi PD006739. Adeno_GP19K. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of group C human adenoviruses type 1 and 6 for five genes of region E3."
      Reichmann H., Schaarschmidt E., Geisler B., Hausmann J., Ortmann D., Bauer U., Flunker G., Seidel W.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiE3GL_ADE06
    AccessioniPrimary (citable) accession number: P68979
    Secondary accession number(s): P03251
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3