Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P68979

- E3GL_ADE06

UniProt

P68979 - E3GL_ADE06

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Early E3 18.5 kDa glycoprotein

Gene
N/A
Organism
Human adenovirus C serotype 6 (HAdV-6) (Human adenovirus 6)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds and retains class I heavy chains in the endoplasmic reticulum during the early period of virus infection, thereby impairing their transport to the cell surface. Also delays the expression of class I alleles that it cannot affect by direct retention. Binds transporters associated with antigen processing (TAP) and acts as a tapasin inhibitor, preventing class I/TAP association. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes (By similarity).By similarity

GO - Molecular functioni

  1. mannose binding Source: UniProtKB-KW

GO - Biological processi

  1. suppression by virus of host adaptive immune response Source: UniProtKB-KW
  2. suppression by virus of host tapasin activity Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host adaptive immune response by virus, Inhibition of host tapasin by virus, Viral immunoevasion

Keywords - Ligandi

Lectin, Mannose-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Early E3 18.5 kDa glycoprotein
Alternative name(s):
E3-19K
E3gp 19 kDa
Short name:
E19
GP19K
OrganismiHuman adenovirus C serotype 6 (HAdV-6) (Human adenovirus 6)
Taxonomic identifieri10534 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell membrane Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717By similarityAdd
BLAST
Chaini18 – 159142Early E3 18.5 kDa glycoproteinPRO_0000036485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 45By similarity
Glycosylationi29 – 291N-linked (GlcNAc...); by hostSequence Analysis
Disulfide bondi39 ↔ 100By similarity
Glycosylationi78 – 781N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Both disulfide bonds are absolutely critical for the interaction with MHC antigens.By similarity
N-glycosylated; high-mannose.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Developmental stagei

Expressed at early period of virus infection.

Keywords - Developmental stagei

Early protein

Structurei

Secondary structure

1
159
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 359
Beta strandi38 – 469
Beta strandi48 – 569
Beta strandi59 – 6911
Beta strandi76 – 838
Beta strandi86 – 938
Helixi96 – 1038
Helixi105 – 1095

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E5XX-ray1.95G/H18-117[»]
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 123106LumenalSequence AnalysisAdd
BLAST
Topological domaini145 – 15915CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi156 – 1594Di-lysine motifBy similarity

Domaini

The lumenal domain binds directly to the peptide-binding domain of class I molecules.
The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Sequence similaritiesi

Belongs to the adenoviridae E19 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR006965. Adenovirus_Gp19K.
[Graphical view]
PfamiPF04881. Adeno_GP19K. 1 hit.
[Graphical view]
ProDomiPD006739. Adeno_GP19K. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68979 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRYMILGLLA LAAVCSAAKK VEFKEPACNV TFKSEANECT TLIKCTTEHE
60 70 80 90 100
KLIIRHKDKI GKYAVYAIWQ PGDTNDYNVT VFQGENRKTF MYKFPFYEMC
110 120 130 140 150
DITMYMSKQY KLWPPQKCLE NTGTFCSTAL LITALALVCT LLYLKYKSRR

SFIDEKKMP
Length:159
Mass (Da):18,438
Last modified:July 21, 1986 - v1
Checksum:iED2519547E18AEB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16037 Genomic DNA. Translation: CAA75990.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16037 Genomic DNA. Translation: CAA75990.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4E5X X-ray 1.95 G/H 18-117 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR006965. Adenovirus_Gp19K.
[Graphical view ]
Pfami PF04881. Adeno_GP19K. 1 hit.
[Graphical view ]
ProDomi PD006739. Adeno_GP19K. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of group C human adenoviruses type 1 and 6 for five genes of region E3."
    Reichmann H., Schaarschmidt E., Geisler B., Hausmann J., Ortmann D., Bauer U., Flunker G., Seidel W.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiE3GL_ADE06
AccessioniPrimary (citable) accession number: P68979
Secondary accession number(s): P03251
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3