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P68921

- LYS_BPVT2

UniProt

P68921 - LYS_BPVT2

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Protein
Lysozyme
Gene
R
Organism
Enterobacteria phage VT2-Sa (Bacteriophage VT2-Sa)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity By similarity.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton donor By similarity
Active sitei44 – 441Nucleophile By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH24. Glycoside Hydrolase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Gene namesi
Name:R
OrganismiEnterobacteria phage VT2-Sa (Bacteriophage VT2-Sa)
Taxonomic identifieri97081 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridae
Virus hostiEscherichia coli O157:H7 [TaxID: 83334]
ProteomesiUP000002665: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Lysozyme
PRO_0000218090Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP68921.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
InterProiIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

P68921-1 [UniParc]FASTAAdd to Basket

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MSRKLRYGLS AAVLALIAAG ASAPEILDQF LDEKEGNHTT AYRDGAGIWT    50
ICRGATRVDG KPVIPGMKLS KEKCDRVNAI ERDKALAWVE KNIKVPLTEP 100
QKAGIASFCP YNIGPGKCFP STFYRRINAG DRKGACEAIR WWIKDGGRDC 150
RIRSNNCYGQ VSRRDQESAL ACWGIDR 177
Length:177
Mass (Da):19,607
Last modified:February 1, 2005 - v1
Checksum:iE546FDCB1201F036
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000363 Genomic DNA. Translation: BAA84328.1.
RefSeqiNP_050544.1. NC_000902.1.

Genome annotation databases

GeneIDi1262225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000363 Genomic DNA. Translation: BAA84328.1 .
RefSeqi NP_050544.1. NC_000902.1.

3D structure databases

ProteinModelPortali P68921.
ModBasei Search...

Protein family/group databases

CAZyi GH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1262225.

Family and domain databases

Gene3Di 1.10.530.40. 1 hit.
InterProi IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view ]
Pfami PF00959. Phage_lysozyme. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of Stx2-converting phage VT2-Sa shows a great divergence in early regulation and replication regions."
    Miyamoto H., Nakai W., Yajima N., Fujibayashi A., Higuchi T., Sato K., Matsushiro A.
    DNA Res. 6:235-240(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLYS_BPVT2
AccessioniPrimary (citable) accession number: P68921
Secondary accession number(s): Q9T0Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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