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P68920

- LYS_BP933

UniProt

P68920 - LYS_BP933

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Protein
Lysozyme
Gene
R, L0108
Organism
Enterobacteria phage 933W (Bacteriophage 933W)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity By similarity.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton donor By similarity
Active sitei44 – 441Nucleophile By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH24. Glycoside Hydrolase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Gene namesi
Name:R
Ordered Locus Names:L0108
OrganismiEnterobacteria phage 933W (Bacteriophage 933W)
Taxonomic identifieri10730 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridae
Virus hostiEscherichia coli O157:H7 [TaxID: 83334]
ProteomesiUP000002135: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Lysozyme
PRO_0000218089Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP68920.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000022686.

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
InterProiIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

P68920-1 [UniParc]FASTAAdd to Basket

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MSRKLRYGLS AAVLALIAAG ASAPEILDQF LDEKEGNHTT AYRDGAGIWT    50
ICRGATRVDG KPVIPGMKLS KEKCDRVNAI ERDKALAWVE KNIKVPLTEP 100
QKAGIASFCP YNIGPGKCFP STFYRRINAG DRKGACEAIR WWIKDGGRDC 150
RIRSNNCYGQ VSRRDQESAL ACWGIDR 177
Length:177
Mass (Da):19,607
Last modified:February 1, 2005 - v1
Checksum:iE546FDCB1201F036
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF125520 Genomic DNA. Translation: AAD25450.1.
RefSeqiNP_049505.1. NC_000924.1.

Genome annotation databases

GeneIDi1261939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF125520 Genomic DNA. Translation: AAD25450.1 .
RefSeqi NP_049505.1. NC_000924.1.

3D structure databases

ProteinModelPortali P68920.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1261939.

Phylogenomic databases

HOGENOMi HOG000022686.

Family and domain databases

Gene3Di 1.10.530.40. 1 hit.
InterProi IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view ]
Pfami PF00959. Phage_lysozyme. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence of Shiga toxin 2 phage 933W from Escherichia coli O157:H7: Shiga toxin as a phage late-gene product."
    Plunkett G. III, Rose D.J., Durfee T.J., Blattner F.R.
    J. Bacteriol. 181:1767-1778(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLYS_BP933
AccessioniPrimary (citable) accession number: P68920
Secondary accession number(s): Q9T0Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3