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P68920 (LYS_BP933) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme

EC=3.2.1.17
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Gene names
Name:R
Ordered Locus Names:L0108
OrganismEnterobacteria phage 933W (Bacteriophage 933W) [Complete proteome]
Taxonomic identifier10730 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridae
Virus hostEscherichia coli O157:H7 [TaxID: 83334]

Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity By similarity.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sequence similarities

Belongs to the glycosyl hydrolase 24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 177177Lysozyme
PRO_0000218089

Sites

Active site351Proton donor By similarity
Active site441Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
P68920 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: E546FDCB1201F036

FASTA17719,607
        10         20         30         40         50         60 
MSRKLRYGLS AAVLALIAAG ASAPEILDQF LDEKEGNHTT AYRDGAGIWT ICRGATRVDG 

        70         80         90        100        110        120 
KPVIPGMKLS KEKCDRVNAI ERDKALAWVE KNIKVPLTEP QKAGIASFCP YNIGPGKCFP 

       130        140        150        160        170 
STFYRRINAG DRKGACEAIR WWIKDGGRDC RIRSNNCYGQ VSRRDQESAL ACWGIDR 

« Hide

References

[1]"Sequence of Shiga toxin 2 phage 933W from Escherichia coli O157:H7: Shiga toxin as a phage late-gene product."
Plunkett G. III, Rose D.J., Durfee T.J., Blattner F.R.
J. Bacteriol. 181:1767-1778(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF125520 Genomic DNA. Translation: AAD25450.1.
RefSeqNP_049505.1. NC_000924.1.

3D structure databases

ProteinModelPortalP68920.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1261939.

Phylogenomic databases

HOGENOMHOG000022686.
ProtClustDBCLSP2343233.

Family and domain databases

Gene3D1.10.530.40. 1 hit.
InterProIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLYS_BP933
AccessionPrimary (citable) accession number: P68920
Secondary accession number(s): Q9T0Q1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: October 16, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries