Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P68920

- LYS_BP933

UniProt

P68920 - LYS_BP933

Protein

Lysozyme

Gene

R

Organism
Enterobacteria phage 933W (Bacteriophage 933W)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.By similarity

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei35 – 351Proton donorBy similarity
    Active sitei44 – 441NucleophileBy similarity

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH24. Glycoside Hydrolase Family 24.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme (EC:3.2.1.17)
    Alternative name(s):
    Endolysin
    Lysis protein
    Muramidase
    Gene namesi
    Name:R
    Ordered Locus Names:L0108
    OrganismiEnterobacteria phage 933W (Bacteriophage 933W)
    Taxonomic identifieri10730 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridae
    Virus hostiEscherichia coli O157:H7 [TaxID: 83334]
    ProteomesiUP000002135: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 177177LysozymePRO_0000218089Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP68920.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 24 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000022686.

    Family and domain databases

    Gene3Di1.10.530.40. 1 hit.
    InterProiIPR002196. Glyco_hydro_24.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view]
    PfamiPF00959. Phage_lysozyme. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P68920-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRKLRYGLS AAVLALIAAG ASAPEILDQF LDEKEGNHTT AYRDGAGIWT    50
    ICRGATRVDG KPVIPGMKLS KEKCDRVNAI ERDKALAWVE KNIKVPLTEP 100
    QKAGIASFCP YNIGPGKCFP STFYRRINAG DRKGACEAIR WWIKDGGRDC 150
    RIRSNNCYGQ VSRRDQESAL ACWGIDR 177
    Length:177
    Mass (Da):19,607
    Last modified:February 1, 2005 - v1
    Checksum:iE546FDCB1201F036
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF125520 Genomic DNA. Translation: AAD25450.1.
    RefSeqiNP_049505.1. NC_000924.1.

    Genome annotation databases

    GeneIDi1261939.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF125520 Genomic DNA. Translation: AAD25450.1 .
    RefSeqi NP_049505.1. NC_000924.1.

    3D structure databases

    ProteinModelPortali P68920.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH24. Glycoside Hydrolase Family 24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1261939.

    Phylogenomic databases

    HOGENOMi HOG000022686.

    Family and domain databases

    Gene3Di 1.10.530.40. 1 hit.
    InterProi IPR002196. Glyco_hydro_24.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view ]
    Pfami PF00959. Phage_lysozyme. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of Shiga toxin 2 phage 933W from Escherichia coli O157:H7: Shiga toxin as a phage late-gene product."
      Plunkett G. III, Rose D.J., Durfee T.J., Blattner F.R.
      J. Bacteriol. 181:1767-1778(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiLYS_BP933
    AccessioniPrimary (citable) accession number: P68920
    Secondary accession number(s): Q9T0Q1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3