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P68905

- ALF_STRP1

UniProt

P68905 - ALF_STRP1

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Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501Glyceraldehyde 3-phosphateBy similarity
Active sitei85 – 851Proton donorBy similarity
Metal bindingi86 – 861Zinc 1; catalyticBy similarity
Metal bindingi106 – 1061Zinc 2By similarity
Metal bindingi136 – 1361Zinc 2By similarity
Metal bindingi178 – 1781Zinc 1; catalyticBy similarity
Binding sitei179 – 1791Dihydroxyacetone phosphate; via amide nitrogenBy similarity
Metal bindingi208 – 2081Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fructose 1,6-bisphosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-1552-MONOMER.
SPYO293653:GHFC-1679-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Ordered Locus Names:SPy_1889, M5005_Spy1607
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 293292Fructose-bisphosphate aldolasePRO_0000178747Add
BLAST

Proteomic databases

PaxDbiP68905.

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_1889.

Structurei

3D structure databases

ProteinModelPortaliP68905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni209 – 2113Dihydroxyacetone phosphate bindingBy similarity
Regioni230 – 2334Dihydroxyacetone phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
HOGENOMiHOG000227793.
KOiK01624.
OMAiTCVTAIQ.
OrthoDBiEOG6HXJ7B.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68905-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIVSAEKFV QAARENGYAV GGFNTNNLEW TQAILRAAEA KQAPVLIQTS
60 70 80 90 100
MGAAKYMGGY KVCQSLITNL VESMGITVPV AIHLDHGHYE DALECIEVGY
110 120 130 140 150
TSIMFDGSHL PVEENLAKTA EVVKIAHAKG VSVEAEVGTI GGEEDGIIGK
160 170 180 190 200
GELAPIEDAK AMVETGIDFL AAGIGNIHGP YPENWEGLAL DHLEKLTAAV
210 220 230 240 250
PGFPIVLHGG SGIPDDQIKE AIRLGVAKVN VNTESQIAFS NATREFARNY
260 270 280 290
EANEAEYDGK KLFDPRKFLA PGMKAVQGAV EERIDVFGSA NKA
Length:293
Mass (Da):31,208
Last modified:January 23, 2007 - v2
Checksum:i8ECD3C3E41A79FD2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34600.1.
CP000017 Genomic DNA. Translation: AAZ52225.1.
RefSeqiNP_269879.1. NC_002737.1.
YP_282970.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK34600; AAK34600; SPy_1889.
AAZ52225; AAZ52225; M5005_Spy1607.
GeneIDi3571297.
902096.
KEGGispy:SPy_1889.
spz:M5005_Spy_1607.
PATRICi19717176. VBIStrPyo79812_1639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34600.1 .
CP000017 Genomic DNA. Translation: AAZ52225.1 .
RefSeqi NP_269879.1. NC_002737.1.
YP_282970.1. NC_007297.1.

3D structure databases

ProteinModelPortali P68905.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_1889.

Proteomic databases

PaxDbi P68905.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK34600 ; AAK34600 ; SPy_1889 .
AAZ52225 ; AAZ52225 ; M5005_Spy1607 .
GeneIDi 3571297.
902096.
KEGGi spy:SPy_1889.
spz:M5005_Spy_1607.
PATRICi 19717176. VBIStrPyo79812_1639.

Phylogenomic databases

eggNOGi COG0191.
HOGENOMi HOG000227793.
KOi K01624.
OMAi TCVTAIQ.
OrthoDBi EOG6HXJ7B.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci SPYO160490:GJ81-1552-MONOMER.
SPYO293653:GHFC-1679-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiALF_STRP1
AccessioniPrimary (citable) accession number: P68905
Secondary accession number(s): P82486, Q48WQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3