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P68896

- PCP_STRP1

UniProt

P68896 - PCP_STRP1

Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Removes 5-oxoproline from various penultimate amino acid residues except L-proline.By similarity

    Catalytic activityi

    Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei78 – 781By similarity
    Active sitei141 – 1411By similarity
    Active sitei165 – 1651By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciSPYO160490:GJ81-420-MONOMER.
    SPYO293653:GHFC-472-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
    Alternative name(s):
    5-oxoprolyl-peptidase
    Pyroglutamyl-peptidase I
    Short name:
    PGP-I
    Short name:
    Pyrase
    Gene namesi
    Name:pcp
    Ordered Locus Names:SPy_0506, M5005_Spy0417
    OrganismiStreptococcus pyogenes serotype M1
    Taxonomic identifieri301447 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215Pyrrolidone-carboxylate peptidasePRO_0000184742Add
    BLAST

    Proteomic databases

    PaxDbiP68896.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi160490.SPy_0506.

    Structurei

    3D structure databases

    ProteinModelPortaliP68896.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C15 family.Curated

    Phylogenomic databases

    eggNOGiCOG2039.
    HOGENOMiHOG000242641.
    KOiK01304.
    OMAiHRTIVER.
    OrthoDBiEOG6X1124.

    Family and domain databases

    Gene3Di3.40.630.20. 1 hit.
    HAMAPiMF_00417. Pyrrolid_peptidase.
    InterProiIPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view]
    PANTHERiPTHR23402. PTHR23402. 1 hit.
    PfamiPF01470. Peptidase_C15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSiPR00706. PYROGLUPTASE.
    PROSITEiPS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P68896-1 [UniParc]FASTAAdd to Basket

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    MKILVTGFDP FGGEAINPAL EAIKKLPATI HGAEIKCIEV PTVFQKSADV    50
    LQQHIESFQP DAVLCIGQAG GRTGLTPERV AINQDDARIP DNEGNQPIDT 100
    PIRADGKAAY FSTLPIKAMV AAIHQAGLPA SVSNTAGTFV CNHLMYQALY 150
    LVDKYCPNAK AGFMHIPFMM EQVVDKPNTA AMNLDDITRG IEAAIFAIVD 200
    FKDRSDLKRV GGATH 215
    Length:215
    Mass (Da):23,132
    Last modified:January 4, 2005 - v1
    Checksum:i2D9E727A09704A69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK33506.1.
    CP000017 Genomic DNA. Translation: AAZ51035.1.
    RefSeqiNP_268785.1. NC_002737.1.
    YP_281780.1. NC_007297.1.

    Genome annotation databases

    EnsemblBacteriaiAAK33506; AAK33506; SPy_0506.
    AAZ51035; AAZ51035; M5005_Spy0417.
    GeneIDi3572511.
    900735.
    KEGGispy:SPy_0506.
    spz:M5005_Spy_0417.
    PATRICi19714727. VBIStrPyo79812_0432.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK33506.1 .
    CP000017 Genomic DNA. Translation: AAZ51035.1 .
    RefSeqi NP_268785.1. NC_002737.1.
    YP_281780.1. NC_007297.1.

    3D structure databases

    ProteinModelPortali P68896.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160490.SPy_0506.

    Proteomic databases

    PaxDbi P68896.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK33506 ; AAK33506 ; SPy_0506 .
    AAZ51035 ; AAZ51035 ; M5005_Spy0417 .
    GeneIDi 3572511.
    900735.
    KEGGi spy:SPy_0506.
    spz:M5005_Spy_0417.
    PATRICi 19714727. VBIStrPyo79812_0432.

    Phylogenomic databases

    eggNOGi COG2039.
    HOGENOMi HOG000242641.
    KOi K01304.
    OMAi HRTIVER.
    OrthoDBi EOG6X1124.

    Enzyme and pathway databases

    BioCyci SPYO160490:GJ81-420-MONOMER.
    SPYO293653:GHFC-472-MONOMER.

    Family and domain databases

    Gene3Di 3.40.630.20. 1 hit.
    HAMAPi MF_00417. Pyrrolid_peptidase.
    InterProi IPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view ]
    PANTHERi PTHR23402. PTHR23402. 1 hit.
    Pfami PF01470. Peptidase_C15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSi PR00706. PYROGLUPTASE.
    PROSITEi PS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700294 / SF370 / Serotype M1.
    2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
      Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
      J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

    Entry informationi

    Entry nameiPCP_STRP1
    AccessioniPrimary (citable) accession number: P68896
    Secondary accession number(s): Q01328, Q490D3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3