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Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.By similarity

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei78By similarity1
Active sitei141By similarity1
Active sitei165By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
Alternative name(s):
5-oxoprolyl-peptidase
Pyroglutamyl-peptidase I
Short name:
PGP-I
Short name:
Pyrase
Gene namesi
Name:pcp
Ordered Locus Names:SPy_0506, M5005_Spy0417
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000750 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001847421 – 215Pyrrolidone-carboxylate peptidaseAdd BLAST215

Proteomic databases

PaxDbiP68896
PRIDEiP68896

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi160490.SPy_0506

Structurei

3D structure databases

ProteinModelPortaliP68896
SMRiP68896
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.Curated

Phylogenomic databases

eggNOGiENOG4108KN7 Bacteria
COG2039 LUCA
HOGENOMiHOG000242641
KOiK01304
OMAiVCNHVFY

Family and domain databases

CDDicd00501 Peptidase_C15, 1 hit
Gene3Di3.40.630.20, 1 hit
HAMAPiMF_00417 Pyrrolid_peptidase, 1 hit
InterProiView protein in InterPro
IPR000816 Peptidase_C15
IPR016125 Peptidase_C15-like
IPR036440 Peptidase_C15-like_sf
IPR029762 PGP-I_bact-type
IPR033694 PGPEP1_Cys_AS
IPR033693 PGPEP1_Glu_AS
PANTHERiPTHR23402 PTHR23402, 1 hit
PfamiView protein in Pfam
PF01470 Peptidase_C15, 1 hit
PIRSFiPIRSF015592 Prld-crbxl_pptds, 1 hit
PRINTSiPR00706 PYROGLUPTASE
SUPFAMiSSF53182 SSF53182, 1 hit
TIGRFAMsiTIGR00504 pyro_pdase, 1 hit
PROSITEiView protein in PROSITE
PS01334 PYRASE_CYS, 1 hit
PS01333 PYRASE_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

P68896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILVTGFDP FGGEAINPAL EAIKKLPATI HGAEIKCIEV PTVFQKSADV
60 70 80 90 100
LQQHIESFQP DAVLCIGQAG GRTGLTPERV AINQDDARIP DNEGNQPIDT
110 120 130 140 150
PIRADGKAAY FSTLPIKAMV AAIHQAGLPA SVSNTAGTFV CNHLMYQALY
160 170 180 190 200
LVDKYCPNAK AGFMHIPFMM EQVVDKPNTA AMNLDDITRG IEAAIFAIVD
210
FKDRSDLKRV GGATH
Length:215
Mass (Da):23,132
Last modified:January 4, 2005 - v1
Checksum:i2D9E727A09704A69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA Translation: AAK33506.1
CP000017 Genomic DNA Translation: AAZ51035.1
RefSeqiNP_268785.1, NC_002737.2

Genome annotation databases

EnsemblBacteriaiAAK33506; AAK33506; SPy_0506
AAZ51035; AAZ51035; M5005_Spy0417
GeneIDi900735
KEGGispy:SPy_0506
spz:M5005_Spy0417
PATRICifig|160490.10.peg.432

Similar proteinsi

Entry informationi

Entry nameiPCP_STRP1
AccessioniPrimary (citable) accession number: P68896
Secondary accession number(s): Q01328, Q490D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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