Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hemoglobin subunit beta

Gene

HBB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.
LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.
Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei22,3-bisphosphoglycerate; via amino nitrogen1
Binding sitei32,3-bisphosphoglycerate1
Metal bindingi64Iron (heme distal ligand)1
Binding sitei832,3-bisphosphoglycerate1
Metal bindingi93Iron (heme proximal ligand)1
Binding sitei1442,3-bisphosphoglycerate1

GO - Molecular functioni

  • heme binding Source: InterPro
  • hemoglobin binding Source: UniProtKB
  • iron ion binding Source: InterPro
  • oxygen binding Source: UniProtKB
  • oxygen transporter activity Source: UniProtKB

GO - Biological processi

  • bicarbonate transport Source: Reactome
  • blood coagulation Source: Reactome
  • cellular oxidant detoxification Source: GOC
  • hydrogen peroxide catabolic process Source: BHF-UCL
  • nitric oxide transport Source: UniProtKB
  • oxygen transport Source: UniProtKB
  • platelet aggregation Source: UniProtKB
  • positive regulation of cell death Source: BHF-UCL
  • positive regulation of nitric oxide biosynthetic process Source: UniProtKB
  • protein heterooligomerization Source: BHF-UCL
  • receptor-mediated endocytosis Source: Reactome
  • regulation of blood pressure Source: UniProtKB-KW
  • regulation of blood vessel size Source: UniProtKB-KW
  • renal absorption Source: UniProtKB
  • response to hydrogen peroxide Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hypotensive agent, Vasoactive

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding, Pyruvate

Enzyme and pathway databases

BioCyciZFISH:G66-32796-MONOMER.
ReactomeiR-HSA-1237044. Erythrocytes take up carbon dioxide and release oxygen.
R-HSA-1247673. Erythrocytes take up oxygen and release carbon dioxide.
R-HSA-2168880. Scavenging of heme from plasma.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Protein family/group databases

TCDBi1.A.107.1.2. the pore-forming globin (globin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta
Alternative name(s):
Beta-globin
Hemoglobin beta chain
Cleaved into the following 2 chains:
Gene namesi
Name:HBB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:4827. HBB.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • cytosol Source: Reactome
  • endocytic vesicle lumen Source: Reactome
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • haptoglobin-hemoglobin complex Source: BHF-UCL
  • hemoglobin complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Heinz body anemias (HEIBAN)4 Publications
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionForm of non-spherocytic hemolytic anemia of Dacie type 1. After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability. Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies) and with glutathione peroxidase deficiency.
See also OMIM:140700
Beta-thalassemia (B-THAL)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of thalassemia. Thalassemias are common monogenic diseases occurring mostly in Mediterranean and Southeast Asian populations. The hallmark of beta-thalassemia is an imbalance in globin-chain production in the adult HbA molecule. Absence of beta chain causes beta(0)-thalassemia, while reduced amounts of detectable beta globin causes beta(+)-thalassemia. In the severe forms of beta-thalassemia, the excess alpha globin chains accumulate in the developing erythroid precursors in the marrow. Their deposition leads to a vast increase in erythroid apoptosis that in turn causes ineffective erythropoiesis and severe microcytic hypochromic anemia. Clinically, beta-thalassemia is divided into thalassemia major which is transfusion dependent, thalassemia intermedia (of intermediate severity), and thalassemia minor that is asymptomatic.
See also OMIM:613985
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00290727E → K in B-THAL; Hb E; confers resistance to severe malaria. 4 PublicationsCorresponds to variant rs33950507dbSNPEnsembl.1
Natural variantiVAR_010145115L → P in B-THAL; Durham-N.C./Brescia. 3 PublicationsCorresponds to variant rs36015961dbSNPEnsembl.1
Natural variantiVAR_003037116A → D in B-THAL; Hradec Kralove; unstable. 1 PublicationCorresponds to variant rs35485099dbSNPEnsembl.1
Natural variantiVAR_003056127V → G in B-THAL; Dhonburi/Neapolis; unstable. 1 PublicationCorresponds to variant rs33925391dbSNPEnsembl.1
Sickle cell anemia (SKCA)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by abnormally shaped red cells resulting in chronic anemia and periodic episodes of pain, serious infections and damage to vital organs. Normal red blood cells are round and flexible and flow easily through blood vessels, but in sickle cell anemia, the abnormal hemoglobin (called Hb S) causes red blood cells to become stiff. They are C-shaped and resembles a sickle. These stiffer red blood cells can led to microvascular occlusion thus cutting off the blood supply to nearby tissues.
See also OMIM:603903
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0028637E → V in SKCA; Hb S; at heterozygosity confers resistance to malaria. 3 PublicationsCorresponds to variant rs334dbSNPEnsembl.1
Beta-thalassemia, dominant, inclusion body type (B-THALIB)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant form of beta thalassemia characterized by moderate anemia, lifelong jaundice, cholelithiasis and splenomegaly, marked morphologic changes in the red cells, erythroid hyperplasia of the bone marrow with increased numbers of multinucleate red cell precursors, and the presence of large inclusion bodies in the normoblasts, both in the marrow and in the peripheral blood after splenectomy.
See also OMIM:603902

Keywords - Diseasei

Congenital dyserythropoietic anemia, Disease mutation, Hereditary hemolytic anemia

Organism-specific databases

DisGeNETi3043.
MalaCardsiHBB.
MIMi140700. phenotype.
141900. gene+phenotype.
603902. phenotype.
603903. phenotype.
611162. phenotype.
613985. phenotype.
OpenTargetsiENSG00000244734.
Orphaneti330041. Autosomal dominant methemoglobinemia.
231222. Beta-thalassemia intermedia.
231214. Beta-thalassemia major.
231237. Delta-beta-thalassemia.
231226. Dominant beta-thalassemia.
178330. Heinz body anemia.
231242. Hemoglobin C - beta-thalassemia.
2132. Hemoglobin C disease.
90039. Hemoglobin D disease.
231249. Hemoglobin E - beta-thalassemia.
2133. Hemoglobin E disease.
330032. Hemoglobin Lepore - beta-thalassemia.
46532. Hereditary persistence of fetal hemoglobin - beta-thalassemia.
251380. Hereditary persistence of fetal hemoglobin - sickle cell disease.
251359. Sickle cell - beta-thalassemia disease.
251365. Sickle cell - hemoglobin C disease.
251370. Sickle cell - hemoglobin D disease.
251375. Sickle cell - hemoglobin E disease.
232. Sickle cell anemia.
PharmGKBiPA29202.

Chemistry databases

ChEMBLiCHEMBL4331.
DrugBankiDB00893. Iron Dextran.

Polymorphism and mutation databases

BioMutaiHBB.
DMDMi56749856.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00000529762 – 147Hemoglobin subunit betaAdd BLAST146
PeptideiPRO_000029664133 – 42LVV-hemorphin-710
PeptideiPRO_000042422633 – 39Spinorphin7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvalineBy similarity1
Modified residuei2N-pyruvate 2-iminyl-valine; in Hb A1b1
Glycosylationi2N-linked (Glc) (glycation); in Hb A1c1
Glycosylationi9N-linked (Glc) (glycation)1
Modified residuei10PhosphoserineCombined sources1
Modified residuei13PhosphothreonineCombined sources1
Glycosylationi18N-linked (Glc) (glycation)1
Modified residuei45PhosphoserineCombined sources1
Modified residuei51PhosphothreonineCombined sources1
Modified residuei60N6-acetyllysine1 Publication1
Glycosylationi67N-linked (Glc) (glycation)1
Modified residuei83N6-acetyllysine1 Publication1
Modified residuei88PhosphothreonineCombined sources1
Modified residuei94S-nitrosocysteine2 Publications1
Glycosylationi121N-linked (Glc) (glycation)1
Modified residuei145N6-acetyllysine; alternate1 Publication1
Glycosylationi145N-linked (Glc) (glycation); alternate1

Post-translational modificationi

Glucose reacts non-enzymatically with the N-terminus of the beta chain to form a stable ketoamine linkage. This takes place slowly and continuously throughout the 120-day life span of the red blood cell. The rate of glycation is increased in patients with diabetes mellitus.
S-nitrosylated; a nitric oxide group is first bound to Fe2+ and then transferred to Cys-94 to allow capture of O2.3 Publications
Acetylated on Lys-60, Lys-83 and Lys-145 upon aspirin exposure.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei60Not glycated1
Sitei83Not glycated1
Sitei96Not glycated1

Keywords - PTMi

Acetylation, Glycation, Glycoprotein, Phosphoprotein, S-nitrosylation

Proteomic databases

EPDiP68871.
MaxQBiP68871.
PaxDbiP68871.
PeptideAtlasiP68871.
PRIDEiP68871.
TopDownProteomicsiP68871.

2D gel databases

REPRODUCTION-2DPAGEIPI00654755.
P68871.
SWISS-2DPAGEP68871.
UCD-2DPAGEP02023.
P68871.

PTM databases

iPTMnetiP68871.
PhosphoSitePlusiP68871.

Miscellaneous databases

PMAP-CutDBP68871.

Expressioni

Tissue specificityi

Red blood cells.1 Publication

Gene expression databases

BgeeiENSG00000244734.
ExpressionAtlasiP68871. baseline and differential.
GenevisibleiP68871. HS.

Organism-specific databases

HPAiCAB009526.
HPA043234.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA). Heterotetramer of two zeta chains and two beta chains in hemoglobin Portland-2, detected in fetuses and neonates with homozygous alpha-thalassemia.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HBA2P6990520EBI-715554,EBI-714680
HBZP020082EBI-715554,EBI-719843

Protein-protein interaction databases

BioGridi109293. 54 interactors.
DIPiDIP-35526N.
IntActiP68871. 8 interactors.
MINTiMINT-5000306.
STRINGi9606.ENSP00000333994.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 17Combined sources12
Helixi21 – 35Combined sources15
Helixi37 – 42Combined sources6
Helixi44 – 46Combined sources3
Helixi52 – 57Combined sources6
Helixi59 – 75Combined sources17
Turni78 – 80Combined sources3
Helixi82 – 95Combined sources14
Helixi102 – 119Combined sources18
Helixi120 – 122Combined sources3
Helixi125 – 143Combined sources19
Helixi144 – 146Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A00X-ray2.00B/D3-147[»]
1A01X-ray1.80B/D3-147[»]
1A0UX-ray2.14B/D3-147[»]
1A0ZX-ray2.00B/D3-147[»]
1A3NX-ray1.80B/D2-147[»]
1A3OX-ray1.80B/D2-147[»]
1ABWX-ray2.00B/D3-147[»]
1ABYX-ray2.60B/D3-147[»]
1AJ9X-ray2.20B2-147[»]
1B86X-ray2.50B/D2-147[»]
1BABX-ray1.50B/D2-147[»]
1BBBX-ray1.70B/D2-147[»]
1BIJX-ray2.30B/D2-147[»]
1BUWX-ray1.90B/D2-147[»]
1BZ0X-ray1.50B/D2-147[»]
1BZ1X-ray1.59B/D2-147[»]
1BZZX-ray1.59B/D2-147[»]
1C7BX-ray1.80B/D2-147[»]
1C7CX-ray1.80B/D2-147[»]
1C7DX-ray1.80B/D2-147[»]
1CBLX-ray1.80A/B/C/D2-147[»]
1CBMX-ray1.74A/B/C/D2-147[»]
1CH4X-ray2.50A/B/C/D2-146[»]
1CLSX-ray1.90B/D2-147[»]
1CMYX-ray3.00B/D2-147[»]
1COHX-ray2.90B/D2-147[»]
1DKEX-ray2.10B/D2-147[»]
1DXTX-ray1.70B/D1-147[»]
1DXUX-ray1.70B/D3-147[»]
1DXVX-ray1.70B/D3-147[»]
1FN3X-ray2.48B/D2-147[»]
1G9VX-ray1.85B/D2-147[»]
1GBUX-ray1.80B/D2-147[»]
1GBVX-ray2.00B/D2-147[»]
1GLIX-ray2.50B/D3-147[»]
1GZXX-ray2.10B/D2-147[»]
1HABX-ray2.30B/D2-147[»]
1HACX-ray2.60B/D2-147[»]
1HBAX-ray2.10B/D2-147[»]
1HBBX-ray1.90B/D2-147[»]
1HBSX-ray3.00B/D/F/H2-147[»]
1HCOX-ray2.70B2-147[»]
1HDBX-ray2.20B/D2-147[»]
1HGAX-ray2.10B/D2-147[»]
1HGBX-ray2.10B/D2-147[»]
1HGCX-ray2.10B/D2-147[»]
1HHOX-ray2.10B2-147[»]
1IRDX-ray1.25B2-147[»]
1J3YX-ray1.55B/D/F/H2-147[»]
1J3ZX-ray1.60B/D/F/H2-147[»]
1J40X-ray1.45B/D/F/H2-147[»]
1J41X-ray1.45B/D/F/H2-147[»]
1J7SX-ray2.20B/D2-147[»]
1J7WX-ray2.00B/D2-147[»]
1J7YX-ray1.70B/D2-147[»]
1JY7X-ray3.20B/D/Q/S/V/X2-147[»]
1K0YX-ray1.87B/D2-147[»]
1K1KX-ray2.00B2-147[»]
1KD2X-ray1.87B/D2-147[»]
1LFLX-ray2.70B/D/Q/S2-147[»]
1LFQX-ray2.60B2-147[»]
1LFTX-ray2.60B2-147[»]
1LFVX-ray2.80B2-147[»]
1LFYX-ray3.30B2-147[»]
1LFZX-ray3.10B2-147[»]
1LJWX-ray2.16B2-147[»]
1M9PX-ray2.10B/D2-147[»]
1MKOX-ray2.18B/D2-147[»]
1NEJX-ray2.10B/D2-147[»]
1NIHX-ray2.60B/D2-147[»]
1NQPX-ray1.73B/D2-147[»]
1O1IX-ray2.30B2-147[»]
1O1JX-ray1.90B/D2-147[»]
1O1KX-ray2.00B/D2-147[»]
1O1LX-ray1.80B/D2-147[»]
1O1MX-ray1.85B/D2-147[»]
1O1NX-ray1.80B/D2-147[»]
1O1OX-ray1.80B/D2-147[»]
1O1PX-ray1.80B/D2-147[»]
1QI8X-ray1.80B/D3-147[»]
1QSHX-ray1.70B/D2-147[»]
1QSIX-ray1.70B/D2-147[»]
1QXDX-ray2.25B/D2-147[»]
1QXEX-ray1.85B/D2-147[»]
1R1XX-ray2.15B2-147[»]
1R1YX-ray1.80B/D2-147[»]
1RPSX-ray2.11B/D2-147[»]
1RQ3X-ray1.91B/D2-147[»]
1RQ4X-ray2.11B/D2-147[»]
1RQAX-ray2.11B/D2-147[»]
1RVWX-ray2.50B2-147[»]
1SDKX-ray1.80B/D2-147[»]
1SDLX-ray1.80B/D2-147[»]
1THBX-ray1.50B/D2-147[»]
1UIWX-ray1.50B/D/F/H2-147[»]
1VWTX-ray1.90B/D2-147[»]
1XXTX-ray1.91B/D2-147[»]
1XY0X-ray1.99B/D2-147[»]
1XYEX-ray2.13B/D2-147[»]
1XZ2X-ray1.90B/D2-147[»]
1XZ4X-ray2.00B/D2-147[»]
1XZ5X-ray2.11B/D2-147[»]
1XZ7X-ray1.90B/D2-147[»]
1XZUX-ray2.16B/D2-147[»]
1XZVX-ray2.11B/D2-147[»]
1Y09X-ray2.25B/D2-147[»]
1Y0AX-ray2.22B/D2-147[»]
1Y0CX-ray2.30B/D2-147[»]
1Y0DX-ray2.10B/D2-147[»]
1Y0TX-ray2.14B/D2-147[»]
1Y0WX-ray2.14B/D2-147[»]
1Y22X-ray2.16B/D2-147[»]
1Y2ZX-ray2.07B/D2-147[»]
1Y31X-ray2.13B/D2-147[»]
1Y35X-ray2.12B/D2-147[»]
1Y45X-ray2.00B/D2-147[»]
1Y46X-ray2.22B/D2-147[»]
1Y4BX-ray2.10B/D2-147[»]
1Y4FX-ray2.00B/D2-147[»]
1Y4GX-ray1.91B/D2-147[»]
1Y4PX-ray1.98B/D2-147[»]
1Y4QX-ray2.11B/D2-147[»]
1Y4RX-ray2.22B/D2-147[»]
1Y4VX-ray1.84B/D2-147[»]
1Y5FX-ray2.14B/D2-147[»]
1Y5JX-ray2.03B/D2-147[»]
1Y5KX-ray2.20B/D2-147[»]
1Y7CX-ray2.10B/D2-147[»]
1Y7DX-ray1.90B/D2-147[»]
1Y7GX-ray2.10B/D2-147[»]
1Y7ZX-ray1.98B/D2-147[»]
1Y83X-ray1.90B/D2-145[»]
1Y85X-ray2.13B/D2-146[»]
1Y8WX-ray2.90B/D2-147[»]
1YDZX-ray3.30B/D2-147[»]
1YE0X-ray2.50B/D2-147[»]
1YE1X-ray4.50B/D2-147[»]
1YE2X-ray1.80B/D2-147[»]
1YENX-ray2.80B/D2-147[»]
1YEOX-ray2.22B/D2-147[»]
1YEQX-ray2.75B/D2-147[»]
1YEUX-ray2.12B/D2-147[»]
1YEVX-ray2.11B/D2-147[»]
1YFFX-ray2.40B/D/F/H2-147[»]
1YG5X-ray2.70B/D2-147[»]
1YGDX-ray2.73B/D2-147[»]
1YGFX-ray2.70B/D2-147[»]
1YH9X-ray2.20B/D2-147[»]
1YHEX-ray2.10B/D2-147[»]
1YHRX-ray2.60B/D2-147[»]
1YIEX-ray2.40B/D2-147[»]
1YIHX-ray2.00B/D2-147[»]
1YVQX-ray1.80B/D2-147[»]
1YVTX-ray1.80B2-147[»]
1YZIX-ray2.07B2-147[»]
2D5ZX-ray1.45B/D2-147[»]
2D60X-ray1.70B/D2-147[»]
2DN1X-ray1.25B2-147[»]
2DN2X-ray1.25B/D2-147[»]
2DN3X-ray1.25B2-147[»]
2DXMneutron diffraction2.10B/D2-147[»]
2H35NMR-B/D2-147[»]
2HBCX-ray2.10B2-147[»]
2HBDX-ray2.20B2-147[»]
2HBEX-ray2.00B2-147[»]
2HBFX-ray2.20B2-147[»]
2HBSX-ray2.05B/D/F/H2-147[»]
2HCOX-ray2.70B2-147[»]
2HHBX-ray1.74B/D2-147[»]
2HHDX-ray2.20B/D2-147[»]
2HHEX-ray2.20B/D4-147[»]
2M6ZNMR-B/D2-147[»]
2W6VX-ray1.80B/D2-147[»]
2W72X-ray1.07B/D3-147[»]
2YRSX-ray2.30B/D/K/O2-147[»]
3B75X-ray2.30B/D/F/H/T2-147[»]
3D17X-ray2.80B/D2-147[»]
3D7OX-ray1.80B2-147[»]
3DUTX-ray1.55B/D2-147[»]
3HHBX-ray1.74B/D2-147[»]
3HXNX-ray2.00B/D2-147[»]
3IC0X-ray1.80B/D2-147[»]
3IC2X-ray2.40B/D2-147[»]
3KMFneutron diffraction2.00C/G2-147[»]
3NL7X-ray1.80B2-147[»]
3NMMX-ray1.60B/D2-147[»]
3ODQX-ray3.10B/D2-147[»]
3ONZX-ray2.09B2-147[»]
3OO4X-ray1.90B2-147[»]
3OO5X-ray2.10B2-147[»]
3P5QX-ray2.00B2-147[»]
3QJBX-ray1.80B2-147[»]
3QJCX-ray2.00B2-147[»]
3QJDX-ray1.56B/D2-147[»]
3QJEX-ray1.80B/D2-147[»]
3R5IX-ray2.20B/D2-147[»]
3S65X-ray1.80B/D2-147[»]
3S66X-ray1.40B2-147[»]
3SZKX-ray3.01B/E2-147[»]
3W4UX-ray1.95B/D/F2-147[»]
3WCPX-ray1.94B/D2-147[»]
3WHMX-ray1.85B/F2-147[»]
4FC3X-ray2.26B2-147[»]
4HHBX-ray1.74B/D2-147[»]
4IJ2X-ray4.24B/D2-147[»]
4L7YX-ray1.80B/D2-147[»]
4M4AX-ray2.05B2-147[»]
4M4BX-ray2.00B2-147[»]
4MQCX-ray2.20B2-147[»]
4MQGX-ray1.68B2-147[»]
4MQHX-ray2.50B2-147[»]
4MQIX-ray1.92B2-147[»]
4N7NX-ray2.75B/D/F/H/J/L2-147[»]
4N7OX-ray2.50B/D/F/H/J/L2-147[»]
4N7PX-ray2.81B/D/F/H/J/L2-147[»]
4N8TX-ray1.90B2-147[»]
4NI0X-ray2.15B2-147[»]
4NI1X-ray1.90B2-147[»]
4ROLX-ray1.70B/D2-147[»]
4ROMX-ray1.90B/D2-147[»]
4WJGX-ray3.101/B/G/L/Q/V2-147[»]
4X0LX-ray2.05B2-147[»]
4XS0X-ray2.55B2-147[»]
5E29X-ray1.85B/D3-147[»]
5E6EX-ray1.76B2-147[»]
5E83X-ray1.80B/D2-147[»]
5EE4X-ray2.30D/F2-147[»]
5HU6X-ray2.90B3-143[»]
5JDOX-ray3.20D3-147[»]
F3-146[»]
5KDQX-ray2.15B/D2-147[»]
5SW7X-ray1.85B2-147[»]
6HBWX-ray2.00B/D2-147[»]
ProteinModelPortaliP68871.
SMRiP68871.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68871.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOVERGENiHBG009709.
InParanoidiP68871.
KOiK13823.
OMAiWTRRFFE.
OrthoDBiEOG091G0R7W.
PhylomeDBiP68871.
TreeFamiTF333268.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHLTPEEKS AVTALWGKVN VDEVGGEALG RLLVVYPWTQ RFFESFGDLS
60 70 80 90 100
TPDAVMGNPK VKAHGKKVLG AFSDGLAHLD NLKGTFATLS ELHCDKLHVD
110 120 130 140
PENFRLLGNV LVCVLAHHFG KEFTPPVQAA YQKVVAGVAN ALAHKYH
Length:147
Mass (Da):15,998
Last modified:January 23, 2007 - v2
Checksum:iA31F6D621C6556A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26Missing in ACD39349 (Ref. 15) Curated1
Sequence conflicti42F → L in AAR96398 (Ref. 13) Curated1

Mass spectrometryi

Molecular mass is 1310 Da from positions 33 - 42. Determined by FAB. 1 Publication

Polymorphismi

Genetic variations in HBB are involved in resistance to malaria [MIMi:611162]. Hemoglobin S (Hb S), which at homozygosity is responsible for sickle cell anemia, is not associated with any clinical abnormality when heterozygous. At heterozygosity, Hb S confers an increase in protection from life-threatening malaria. Additional variants conferring resistance against severe malaria are hemoglobin C (Hb C) and hemoglobin E (Hb E).3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0028562V → A in Raleigh; O(2) affinity down. Corresponds to variant rs33949930dbSNPEnsembl.1
Natural variantiVAR_0028573H → L in Graz. 1 PublicationCorresponds to variant rs35906307dbSNPEnsembl.1
Natural variantiVAR_0028583H → Q in Okayama; O(2) affinity up. Corresponds to variant rs713040dbSNPEnsembl.1
Natural variantiVAR_0028593H → R in Deer Lodge; O(2) affinity up. Corresponds to variant rs33983205dbSNPEnsembl.1
Natural variantiVAR_0028603H → Y in Fukuoka. Corresponds to variant rs35906307dbSNPEnsembl.1
Natural variantiVAR_0028616P → R in Warwickshire. Corresponds to variant rs34769005dbSNPEnsembl.1
Natural variantiVAR_0028627E → A in G-Makassar. Corresponds to variant rs334dbSNPEnsembl.1
Natural variantiVAR_0028647E → K in Hb C; confers resistance to severe malaria. 2 PublicationsCorresponds to variant rs33930165dbSNPEnsembl.1
Natural variantiVAR_0028657E → Q in Machida. Corresponds to variant rs33930165dbSNPEnsembl.1
Natural variantiVAR_0028637E → V in SKCA; Hb S; at heterozygosity confers resistance to malaria. 3 PublicationsCorresponds to variant rs334dbSNPEnsembl.1
Natural variantiVAR_0028668E → G in G-San Jose; mildly unstable. Corresponds to variant rs34948328dbSNPEnsembl.1
Natural variantiVAR_0028678E → K in G-Siriraj. Corresponds to variant rs34948328dbSNPEnsembl.1
Natural variantiVAR_0028689K → E in N-Timone. 1 PublicationCorresponds to variant rs33932981dbSNPEnsembl.1
Natural variantiVAR_0028699K → Q in J-Luhe. Corresponds to variant rs33926764dbSNPEnsembl.1
Natural variantiVAR_0028709K → T in Rio Grande. 1 PublicationCorresponds to variant rs33932981dbSNPEnsembl.1
Natural variantiVAR_00287110S → C in Porto Alegre; O(2) affinity up. Corresponds to variant rs33918131dbSNPEnsembl.1
Natural variantiVAR_00287211A → D in Ankara. 1 PublicationCorresponds to variant rs33947457dbSNPEnsembl.1
Natural variantiVAR_02539311A → V in Iraq-Halabja. 1 PublicationCorresponds to variant rs33947457dbSNPEnsembl.1
Natural variantiVAR_00287312V → D in Windsor; O(2) affinity up; unstable. 1 PublicationCorresponds to variant rs33974228dbSNPEnsembl.1
Natural variantiVAR_00287412V → I in Hamilton. Corresponds to variant rs33974228dbSNPEnsembl.1
Natural variantiVAR_00287514A → D in J-Lens. Corresponds to variant rs35203747dbSNPEnsembl.1
Natural variantiVAR_00287615L → P in Saki; unstable. Corresponds to variant rs33935445dbSNPEnsembl.1
Natural variantiVAR_00287715L → R in Soegn; unstable. Corresponds to variant rs33935445dbSNPEnsembl.1
Natural variantiVAR_00287816W → G in Randwick; unstable. 1 PublicationCorresponds to variant rs33946157dbSNPEnsembl.1
Natural variantiVAR_00287916W → R in Belfast; O(2) affinity up; unstable. Corresponds to variant rs33946157dbSNPEnsembl.1
Natural variantiVAR_00288017G → D in J-Baltimore/J-Trinidad/J-Ireland/J-Georgia/N-New Haven. Corresponds to variant rs33962676dbSNPEnsembl.1
Natural variantiVAR_00288117G → R in D-Bushman. Corresponds to variant rs63751285dbSNPEnsembl.1
Natural variantiVAR_00288218K → E in Nagasaki. Corresponds to variant rs33986703dbSNPEnsembl.1
Natural variantiVAR_00288318K → N in J-Amiens. Corresponds to variant rs36006214dbSNPEnsembl.1
Natural variantiVAR_00288418K → Q in Nikosia. Corresponds to variant rs33986703dbSNPEnsembl.1
Natural variantiVAR_00288519V → M in Baden; slightly unstable. Corresponds to variant rs35802118dbSNPEnsembl.1
Natural variantiVAR_00288620N → D in Alamo. Corresponds to variant rs34866629dbSNPEnsembl.1
Natural variantiVAR_00288720N → K in D-Ouleh RABAH. Corresponds to variant rs63750840dbSNPEnsembl.1
Natural variantiVAR_00288820N → S in Malay. Corresponds to variant rs33972047dbSNPEnsembl.1
Natural variantiVAR_00288921V → M in Olympia; O(2) affinity up. Corresponds to variant rs35890959dbSNPEnsembl.1
Natural variantiVAR_00289022D → G in Connecticut; O(2) affinity down. Corresponds to variant rs33977536dbSNPEnsembl.1
Natural variantiVAR_00289222D → H in Karlskoga. 1 PublicationCorresponds to variant rs33950093dbSNPEnsembl.1
Natural variantiVAR_00289122D → N in Cocody. Corresponds to variant rs33950093dbSNPEnsembl.1
Natural variantiVAR_00289322D → Y in Yusa. Corresponds to variant rs33950093dbSNPEnsembl.1
Natural variantiVAR_00289423E → A in G-Coushatta/G-Saskatoon/G-Taegu/Hsin Chu. Corresponds to variant rs33936254dbSNPEnsembl.1
Natural variantiVAR_00289523E → G in G-Taipei. Corresponds to variant rs33936254dbSNPEnsembl.1
Natural variantiVAR_00289623E → K in E-Saskatoon; unstable. Corresponds to variant rs33959855dbSNPEnsembl.1
Natural variantiVAR_00289723E → Q in D-Iran. Corresponds to variant rs33959855dbSNPEnsembl.1
Natural variantiVAR_00289823E → V in D-Granada. Corresponds to variant rs33936254dbSNPEnsembl.1
Natural variantiVAR_00289924V → D in Strasbourg; O(2) affinity up. Corresponds to variant rs33945546dbSNPEnsembl.1
Natural variantiVAR_00290024V → F in Palmerston North; O(2) affinity up; unstable. 1 PublicationCorresponds to variant rs33929459dbSNPEnsembl.1
Natural variantiVAR_00290124V → G in Miyashiro; O(2) affinity up; unstable. 1 PublicationCorresponds to variant rs33945546dbSNPEnsembl.1
Natural variantiVAR_06916924Missing in Freiburg. 1 PublicationCorresponds to variant rs34160180dbSNPEnsembl.1
Natural variantiVAR_00290225G → D in Moscva; O(2) affinity down; unstable. Corresponds to variant rs33968721dbSNPEnsembl.1
Natural variantiVAR_00290325G → R in Riverdale-Bronx; O(2) affinity up; unstable. Corresponds to variant rs33972975dbSNPEnsembl.1
Natural variantiVAR_00290425G → V in Savannah; unstable. Corresponds to variant rs33968721dbSNPEnsembl.1
Natural variantiVAR_00290526G → D in J-Auckland; unstable; O(2) affinity down. 1 PublicationCorresponds to variant rs35474880dbSNPEnsembl.1
Natural variantiVAR_00290626G → R in G-Taiwan Ami. Corresponds to variant rs34404985dbSNPEnsembl.1
Natural variantiVAR_00290727E → K in B-THAL; Hb E; confers resistance to severe malaria. 4 PublicationsCorresponds to variant rs33950507dbSNPEnsembl.1
Natural variantiVAR_00290827E → V in Henri Mondor; slightly unstable. Corresponds to variant rs33915112dbSNPEnsembl.1
Natural variantiVAR_00290928A → D in Volga/Drenthe; unstable. Corresponds to variant rs33954632dbSNPEnsembl.1
Natural variantiVAR_00291028A → S in Knossos. 1 PublicationCorresponds to variant rs35424040dbSNPEnsembl.1
Natural variantiVAR_00291128A → V in Grange-blanche; O(2) affinity up. 1 PublicationCorresponds to variant rs33954632dbSNPEnsembl.1
Natural variantiVAR_00291229L → P in Genova/Hyogo; unstable. Corresponds to variant rs33916412dbSNPEnsembl.1
Natural variantiVAR_03523629L → Q in St Louis. 1 PublicationCorresponds to variant rs33916412dbSNPEnsembl.1
Natural variantiVAR_00291330G → D in Lufkin; unstable. Corresponds to variant rs35685286dbSNPEnsembl.1
Natural variantiVAR_00291431R → S in Tacoma; unstable. Corresponds to variant rs1135071dbSNPEnsembl.1
Natural variantiVAR_00291532L → P in Yokohama; unstable. 1 PublicationCorresponds to variant rs33920173dbSNPEnsembl.1
Natural variantiVAR_00291633L → R in Castilla; unstable. Corresponds to variant rs33948578dbSNPEnsembl.1
Natural variantiVAR_00291733L → V in Muscat; slightly unstable. 1 PublicationCorresponds to variant rs34314652dbSNPEnsembl.1
Natural variantiVAR_02539435V → D in Santander; unstable. 1 PublicationCorresponds to variant rs1135101dbSNPEnsembl.1
Natural variantiVAR_00291835V → F in Pitie-Salpetriere; O(2) affinity up. Corresponds to variant rs1141387dbSNPEnsembl.1
Natural variantiVAR_02539535V → L in Nantes; increased oxygen affinity. 1 PublicationCorresponds to variant rs1141387dbSNPEnsembl.1
Natural variantiVAR_00291936Y → F in Philly; O(2) affinity up; unstable. Corresponds to variant rs35857380dbSNPEnsembl.1
Natural variantiVAR_00292037P → R in Sunnybrook. Corresponds to variant rs33993004dbSNPEnsembl.1
Natural variantiVAR_00292137P → S in North Chicago; O(2) affinity up. 1 PublicationCorresponds to variant rs33948615dbSNPEnsembl.1
Natural variantiVAR_00292237P → T in Linkoping/Finlandia; O(2) affinity up. 1 PublicationCorresponds to variant rs33948615dbSNPEnsembl.1
Natural variantiVAR_00292338W → G in Howick. 1 PublicationCorresponds to variant rs33994623dbSNPEnsembl.1
Natural variantiVAR_00292538W → R in Rothschild; O(2) affinity down. 1 PublicationCorresponds to variant rs33994623dbSNPEnsembl.1
Natural variantiVAR_00292438W → S in Hirose; O(2) affinity up. Corresponds to variant rs33991059dbSNPEnsembl.1
Natural variantiVAR_00292639T → N in Hinwil; O(2) affinity up. 1 PublicationCorresponds to variant rs34703513dbSNPEnsembl.1
Natural variantiVAR_00292740Q → E in Vaasa; unstable. Corresponds to variant rs76728603dbSNPEnsembl.1
Natural variantiVAR_00292840Q → K in Alabama. 1 PublicationCorresponds to variant rs76728603dbSNPEnsembl.1
Natural variantiVAR_00292940Q → R in Tianshui. Corresponds to variant rs35973315dbSNPEnsembl.1
Natural variantiVAR_00293042F → Y in Mequon. Corresponds to variant rs33926796dbSNPEnsembl.1
Natural variantiVAR_03523742Missing in Bruxelles. 1 Publication1
Natural variantiVAR_00293143F → L in Louisville; unstable. 1 PublicationCorresponds to variant rs33924146dbSNPEnsembl.1
Natural variantiVAR_03523943F → S in Hammersmith. 1 PublicationCorresponds to variant rs34378160dbSNPEnsembl.1
Natural variantiVAR_03523843Missing in Bruxelles. 1 Publication1
Natural variantiVAR_00293244E → Q in Hoshida/Chaya. Corresponds to variant rs33922842dbSNPEnsembl.1
Natural variantiVAR_00293345S → C in Mississippi. Corresponds to variant rs34868397dbSNPEnsembl.1
Natural variantiVAR_00293446F → S in Cheverly; unstable. Corresponds to variant rs33978338dbSNPEnsembl.1
Natural variantiVAR_00293547G → E in K-Ibadan. Corresponds to variant rs35303218dbSNPEnsembl.1
Natural variantiVAR_00293648D → A in Avicenna. Corresponds to variant rs33980484dbSNPEnsembl.1
Natural variantiVAR_00293748D → G in Gavello. Corresponds to variant rs33980484dbSNPEnsembl.1
Natural variantiVAR_00293848D → Y in Maputo. 1 PublicationCorresponds to variant rs33932070dbSNPEnsembl.1
Natural variantiVAR_00293949L → P in Bab-Saadoum; slightly unstable. Corresponds to variant rs33952850dbSNPEnsembl.1
Natural variantiVAR_00294050S → F in Las Palmas; slightly unstable. 2 PublicationsCorresponds to variant rs33960931dbSNPEnsembl.1
Natural variantiVAR_00294151T → K in Edmonton. 1
Natural variantiVAR_00294252P → R in Willamette; O(2) affinity up; unstable. Corresponds to variant rs33969727dbSNPEnsembl.1
Natural variantiVAR_00294353D → A in Ocho Rios. Corresponds to variant rs33919924dbSNPEnsembl.1
Natural variantiVAR_00294453D → H in Summer Hill. Corresponds to variant rs33961886dbSNPEnsembl.1
Natural variantiVAR_00294555V → D in Jacksonville; O(2) affinity up; unstable. 1 PublicationCorresponds to variant rs34037627dbSNPEnsembl.1
Natural variantiVAR_00294656M → K in Matera; unstable. 1 PublicationCorresponds to variant rs35094013dbSNPEnsembl.1
Natural variantiVAR_00294757G → R in Hamadan. Corresponds to variant rs33935983dbSNPEnsembl.1
Natural variantiVAR_00294858N → K in G-ferrara; unstable. Corresponds to variant rs35278874dbSNPEnsembl.1
Natural variantiVAR_00294959P → R in Dhofar/Yukuhashi. Corresponds to variant rs33991472dbSNPEnsembl.1
Natural variantiVAR_00295060K → E in I-High Wycombe. Corresponds to variant rs33969400dbSNPEnsembl.1
Natural variantiVAR_00295161V → A in Collingwood; unstable. Corresponds to variant rs33931779dbSNPEnsembl.1
Natural variantiVAR_00295262K → E in N-Seatlle. Corresponds to variant rs33995148dbSNPEnsembl.1
Natural variantiVAR_00295362K → M in Bologna; O(2) affinity down. Corresponds to variant rs34974709dbSNPEnsembl.1
Natural variantiVAR_00295462K → N in Hikari. Corresponds to variant rs34446260dbSNPEnsembl.1
Natural variantiVAR_00295563A → D in J-Europa. 1 PublicationCorresponds to variant rs34151786dbSNPEnsembl.1
Natural variantiVAR_00295663A → P in Duarte; unstable. Corresponds to variant rs34933455dbSNPEnsembl.1
Natural variantiVAR_00295764H → Y in M-Saskatoon; O(2) affinity up. 1 PublicationCorresponds to variant rs33922873dbSNPEnsembl.1
Natural variantiVAR_00295866K → M in J-Antakya. 1 PublicationCorresponds to variant rs33932548dbSNPEnsembl.1
Natural variantiVAR_00295966K → N in J-Sicilia. 1 PublicationCorresponds to variant rs35747961dbSNPEnsembl.1
Natural variantiVAR_00296066K → Q in J-Cairo. 1 PublicationCorresponds to variant rs35353749dbSNPEnsembl.1
Natural variantiVAR_00296167K → T in Chico; O(2) affinity down. Corresponds to variant rs35939489dbSNPEnsembl.1
Natural variantiVAR_00296268V → A in Sydney; unstable. Corresponds to variant rs33918343dbSNPEnsembl.1
Natural variantiVAR_03524068V → D in Bristol. 1 Publication1
Natural variantiVAR_04006068V → G in non-spherocytic haemolytic anemia; Manukau. 1 PublicationCorresponds to variant rs33918343dbSNPEnsembl.1
Natural variantiVAR_00296368V → M in Alesha; unstable. 1 PublicationCorresponds to variant rs36008922dbSNPEnsembl.1
Natural variantiVAR_00296469L → H in Brisbane; O(2) affinity up. 1 PublicationCorresponds to variant rs33972593dbSNPEnsembl.1
Natural variantiVAR_00296569L → P in Mizuho; unstable. 1 PublicationCorresponds to variant rs33972593dbSNPEnsembl.1
Natural variantiVAR_00296670G → D in Rambam. 1 PublicationCorresponds to variant rs34718174dbSNPEnsembl.1
Natural variantiVAR_00296770G → R in Kenitra. Corresponds to variant rs33947415dbSNPEnsembl.1
Natural variantiVAR_00296870G → S in City of Hope. 1 PublicationCorresponds to variant rs33947415dbSNPEnsembl.1
Natural variantiVAR_00296971A → D in Seattle; O(2) affinity down; unstable. Corresponds to variant rs33946401dbSNPEnsembl.1
Natural variantiVAR_00297072F → S in Christchurch; unstable. Corresponds to variant rs34362537dbSNPEnsembl.1
Natural variantiVAR_00297174D → G in Tilburg; O(2) affinity down. Corresponds to variant rs33967755dbSNPEnsembl.1
Natural variantiVAR_00297274D → V in Mobile; O(2) affinity down. Corresponds to variant rs33967755dbSNPEnsembl.1
Natural variantiVAR_00297374D → Y in Vancouver; O(2) affinity down. Corresponds to variant rs33945705dbSNPEnsembl.1
Natural variantiVAR_00297475G → R in Aalborg; unstable. Corresponds to variant rs33916541dbSNPEnsembl.1
Natural variantiVAR_00297575G → V in Bushwick; unstable. Corresponds to variant rs33976006dbSNPEnsembl.1
Natural variantiVAR_00297676L → P in Atlanta; unstable. 1 PublicationCorresponds to variant rs33950542dbSNPEnsembl.1
Natural variantiVAR_00297776L → R in Pasadena; O(2) affinity up; unstable. Corresponds to variant rs33950542dbSNPEnsembl.1
Natural variantiVAR_00297877A → D in J-Chicago. Corresponds to variant rs33985847dbSNPEnsembl.1
Natural variantiVAR_00297978H → D in J-Iran. Corresponds to variant rs33991294dbSNPEnsembl.1
Natural variantiVAR_00298078H → R in Costa Rica. 1 PublicationCorresponds to variant rs33952543dbSNPEnsembl.1
Natural variantiVAR_00298178H → Y in Fukuyama. Corresponds to variant rs33991294dbSNPEnsembl.1
Natural variantiVAR_00298279L → R in Quin-hai. 1 PublicationCorresponds to variant rs34870172dbSNPEnsembl.1
Natural variantiVAR_00298380D → Y in Tampa. Corresponds to variant rs33990858dbSNPEnsembl.1
Natural variantiVAR_00298481N → K in G-Szuhu/Gifu. Corresponds to variant rs35890380dbSNPEnsembl.1
Natural variantiVAR_01266382L → H in La Roche-sur-Yon; unstable and O(2) affinity up. 1 PublicationCorresponds to variant rs33936967dbSNPEnsembl.1
Natural variantiVAR_00298582L → R in Baylor; unstable. Corresponds to variant rs33936967dbSNPEnsembl.1
Natural variantiVAR_04927382L → V.Corresponds to variant rs11549406dbSNPEnsembl.1
Natural variantiVAR_00298683K → M in Helsinki; O(2) affinity up. 1 PublicationCorresponds to variant rs33987903dbSNPEnsembl.1
Natural variantiVAR_01266483K → N in Providence. Corresponds to variant rs33991993dbSNPEnsembl.1
Natural variantiVAR_02539684G → D in Pyrgos. 1 PublicationCorresponds to variant rs1803195dbSNPEnsembl.1
Natural variantiVAR_00298784G → R in Muskegon. Corresponds to variant rs33930385dbSNPEnsembl.1
Natural variantiVAR_00298885T → I in Kofu. 1 PublicationCorresponds to variant rs35914488dbSNPEnsembl.1
Natural variantiVAR_00298987A → D in Olomouc; O(2) affinity up. 1 PublicationCorresponds to variant rs35819837dbSNPEnsembl.1
Natural variantiVAR_00299088T → I in Quebec-Chori. Corresponds to variant rs33993568dbSNPEnsembl.1
Natural variantiVAR_00299188T → K in D-Ibadan. Corresponds to variant rs33993568dbSNPEnsembl.1
Natural variantiVAR_00299288T → P in Valletta. Corresponds to variant rs35553496dbSNPEnsembl.1
Natural variantiVAR_00299389L → P in Santa Ana; unstable. Corresponds to variant rs33940204dbSNPEnsembl.1
Natural variantiVAR_00299489L → R in Boras; unstable. Corresponds to variant rs33940204dbSNPEnsembl.1
Natural variantiVAR_00299590S → N in Creteil; O(2) affinity up. Corresponds to variant rs33917628dbSNPEnsembl.1
Natural variantiVAR_00299690S → R in Vanderbilt; O(2) affinity up. Corresponds to variant rs35351128dbSNPEnsembl.1
Natural variantiVAR_00299791E → D in Pierre-Benite; O(2) affinity up. 1 PublicationCorresponds to variant rs35002698dbSNPEnsembl.1
Natural variantiVAR_00299891E → K in Agenogi; O(2) affinity down. Corresponds to variant rs33913712dbSNPEnsembl.1
Natural variantiVAR_00299992L → P in Sabine; unstable. Corresponds to variant rs33917785dbSNPEnsembl.1
Natural variantiVAR_00300092L → R in Caribbean; O(2) affinity down; unstable. 1 PublicationCorresponds to variant rs33917785dbSNPEnsembl.1
Natural variantiVAR_00300193H → D in J-Altgelds Gardens; unstable. 1 PublicationCorresponds to variant rs33924775dbSNPEnsembl.1
Natural variantiVAR_00300293H → N in Isehara; unstable. 1 PublicationCorresponds to variant rs33924775dbSNPEnsembl.1
Natural variantiVAR_00300393H → P in Newcastle and Duino; associated with S-104 in Duino; unstable. 1 PublicationCorresponds to variant rs33974325dbSNPEnsembl.1
Natural variantiVAR_00300493H → Q in Istambul; O(2) affinity up; unstable. 1 PublicationCorresponds to variant rs34083951dbSNPEnsembl.1
Natural variantiVAR_00300594C → R in Okazaki; O(2) affinity up; unstable. Corresponds to variant rs33972927dbSNPEnsembl.1
Natural variantiVAR_00300695D → G in Chandigarh. Corresponds to variant rs34579351dbSNPEnsembl.1
Natural variantiVAR_00300795D → H in Barcelona; O(2) affinity up. Corresponds to variant rs33959340dbSNPEnsembl.1
Natural variantiVAR_00300895D → N in Bunbury; O(2) affinity up. 1 PublicationCorresponds to variant rs33959340dbSNPEnsembl.1
Natural variantiVAR_00300996K → M in J-Cordoba. Corresponds to variant rs35204496dbSNPEnsembl.1
Natural variantiVAR_00301096K → N in Detroit. Corresponds to variant rs36038739dbSNPEnsembl.1
Natural variantiVAR_00301197L → P in Debrousse; unstable; O(2) affinity up. 1 PublicationCorresponds to variant rs36081208dbSNPEnsembl.1
Natural variantiVAR_00301297L → V in Regina; O(2) affinity up. Corresponds to variant rs34665886dbSNPEnsembl.1
Natural variantiVAR_00301398H → L in Wood; O(2) affinity up. Corresponds to variant rs33951978dbSNPEnsembl.1
Natural variantiVAR_00301498H → P in Nagoya; O(2) affinity up; unstable. 1 PublicationCorresponds to variant rs33951978dbSNPEnsembl.1
Natural variantiVAR_00301598H → Q in Malmoe; O(2) affinity up. Corresponds to variant rs34515413dbSNPEnsembl.1
Natural variantiVAR_00301698H → Y in Moriguchi. Corresponds to variant rs33950993dbSNPEnsembl.1
Natural variantiVAR_00301799V → G in Nottingham; unstable. Corresponds to variant rs33985510dbSNPEnsembl.1
Natural variantiVAR_003018100D → E in Coimbra; O(2) affinity up. 1 PublicationCorresponds to variant rs34013622dbSNPEnsembl.1
Natural variantiVAR_003019101P → L in Brigham; O(2) affinity up. Corresponds to variant rs33965000dbSNPEnsembl.1
Natural variantiVAR_003020101P → R in New Mexico. Corresponds to variant rs33965000dbSNPEnsembl.1
Natural variantiVAR_003021102E → D in Potomac; O(2) affinity up. Corresponds to variant rs35209591dbSNPEnsembl.1
Natural variantiVAR_003022102E → G in Alberta; O(2) affinity up. Corresponds to variant rs33937393dbSNPEnsembl.1
Natural variantiVAR_003023102E → K in British Columbia; O(2) affinity up. Corresponds to variant rs33966487dbSNPEnsembl.1
Natural variantiVAR_003024102E → Q in Rush; unstable. 1 PublicationCorresponds to variant rs33966487dbSNPEnsembl.1
Natural variantiVAR_003025103N → S in Beth Israel; O(2) affinity down; unstable. Corresponds to variant rs33948057dbSNPEnsembl.1
Natural variantiVAR_003026103N → Y in St Mande; O(2) affinity down. 1 PublicationCorresponds to variant rs33927739dbSNPEnsembl.1
Natural variantiVAR_003027104F → L in Heathrow; O(2) affinity up. Corresponds to variant rs35067717dbSNPEnsembl.1
Natural variantiVAR_003028105R → S in Camperdown and Duino; associated with P-92 in Duino; unstable. 2 PublicationsCorresponds to variant rs33914944dbSNPEnsembl.1
Natural variantiVAR_003029105R → T in Sherwood Forest. Corresponds to variant rs33911434dbSNPEnsembl.1
Natural variantiVAR_003030108G → R in Burke; O(2) affinity down; unstable. 1 PublicationCorresponds to variant rs35017910dbSNPEnsembl.1
Natural variantiVAR_003031109N → K in Presbyterian; O(2) affinity down; unstable. 1 PublicationCorresponds to variant rs34933751dbSNPEnsembl.1
Natural variantiVAR_003032110V → M in San Diego; O(2) affinity up. Corresponds to variant rs33969677dbSNPEnsembl.1
Natural variantiVAR_003033111L → P in Showa-Yakushiji. Corresponds to variant rs35256489dbSNPEnsembl.1
Natural variantiVAR_003034112V → A in Stanmore; O(2) affinity down; unstable. 1 PublicationCorresponds to variant rs35871407dbSNPEnsembl.1
Natural variantiVAR_025397113C → F in Canterbury. 1 PublicationCorresponds to variant rs33932908dbSNPEnsembl.1
Natural variantiVAR_003035113C → R in Indianapolis. 2 PublicationsCorresponds to variant rs35849199dbSNPEnsembl.1
Natural variantiVAR_003036113C → Y in Yahata. 1 PublicationCorresponds to variant rs33932908dbSNPEnsembl.1
Natural variantiVAR_010144115L → M in Zengcheng. 1 PublicationCorresponds to variant rs33917394dbSNPEnsembl.1
Natural variantiVAR_010145115L → P in B-THAL; Durham-N.C./Brescia. 3 PublicationsCorresponds to variant rs36015961dbSNPEnsembl.1
Natural variantiVAR_003037116A → D in B-THAL; Hradec Kralove; unstable. 1 PublicationCorresponds to variant rs35485099dbSNPEnsembl.1
Natural variantiVAR_003038116A → P in Madrid; unstable. Corresponds to variant rs34945623dbSNPEnsembl.1
Natural variantiVAR_025398117H → L in Vexin; increased oxygen affinity. 1 PublicationCorresponds to variant rs33978082dbSNPEnsembl.1
Natural variantiVAR_003039117H → Q in Hafnia. Corresponds to variant rs35209776dbSNPEnsembl.1
Natural variantiVAR_003040118H → P in Saitama; unstable. 1 PublicationCorresponds to variant rs33935673dbSNPEnsembl.1
Natural variantiVAR_003041118H → R in P-Galveston. Corresponds to variant rs33935673dbSNPEnsembl.1
Natural variantiVAR_025399118H → Y in Tsukumi. 1 PublicationCorresponds to variant rs33935527dbSNPEnsembl.1
Natural variantiVAR_003042120G → A in Iowa. Corresponds to variant rs33947020dbSNPEnsembl.1
Natural variantiVAR_003043121K → E in Hijiyama. Corresponds to variant rs33924134dbSNPEnsembl.1
Natural variantiVAR_003044121K → I in Jianghua. 1 PublicationCorresponds to variant rs34303736dbSNPEnsembl.1
Natural variantiVAR_003045121K → Q in Takamatsu. Corresponds to variant rs33924134dbSNPEnsembl.1
Natural variantiVAR_003046122E → A in D-Neath. 1 PublicationCorresponds to variant rs33987957dbSNPEnsembl.1
Natural variantiVAR_003047122E → G in St Francis. Corresponds to variant rs33987957dbSNPEnsembl.1
Natural variantiVAR_003049122E → K in O-Arab. Corresponds to variant rs33946267dbSNPEnsembl.1
Natural variantiVAR_003048122E → Q in D-Los Angeles/D-Punjab/D-Portugal/D-Chicago/D-Oak Ridge. Corresponds to variant rs33946267dbSNPEnsembl.1
Natural variantiVAR_003050122E → V in D-Camperdown/Beograd. Corresponds to variant rs33987957dbSNPEnsembl.1
Natural variantiVAR_003051124T → I in Villejuif; asymptomatic variant. 1 PublicationCorresponds to variant rs33935383dbSNPEnsembl.1
Natural variantiVAR_003053125P → Q in Ty Gard; O(2) affinity up. 1 PublicationCorresponds to variant rs33983276dbSNPEnsembl.1
Natural variantiVAR_003052125P → R in Khartoum; unstable. Corresponds to variant rs33983276dbSNPEnsembl.1
Natural variantiVAR_003054125P → S in Tunis. Corresponds to variant rs35461710dbSNPEnsembl.1
Natural variantiVAR_003055127V → A in Beirut. Corresponds to variant rs33925391dbSNPEnsembl.1
Natural variantiVAR_003057127V → E in Hofu; unstable. Corresponds to variant rs33925391dbSNPEnsembl.1
Natural variantiVAR_003056127V → G in B-THAL; Dhonburi/Neapolis; unstable. 1 PublicationCorresponds to variant rs33925391dbSNPEnsembl.1
Natural variantiVAR_003058128Q → E in Complutense. 1 PublicationCorresponds to variant rs33971634dbSNPEnsembl.1
Natural variantiVAR_003059128Q → K in Brest; unstable. 1 PublicationCorresponds to variant rs33971634dbSNPEnsembl.1
Natural variantiVAR_003060129A → D in J-Guantanamo; unstable. Corresponds to variant rs33957286dbSNPEnsembl.1
Natural variantiVAR_003061130A → P in Crete; O(2) affinity up; unstable. Corresponds to variant rs35939430dbSNPEnsembl.1
Natural variantiVAR_003062130A → V in La Desirade; O(2) affinity down; unstable. 1 PublicationCorresponds to variant rs111645889dbSNPEnsembl.1
Natural variantiVAR_003063131Y → D in Wien; unstable. Corresponds to variant rs35834416dbSNPEnsembl.1
Natural variantiVAR_003064131Y → S in Nevers. Corresponds to variant rs33937535dbSNPEnsembl.1
Natural variantiVAR_003065132Q → E in Camden/Tokuchi/Motown. Corresponds to variant rs33910209dbSNPEnsembl.1
Natural variantiVAR_003066132Q → K in Shelby/Leslie/Deaconess; unstable. 1 PublicationCorresponds to variant rs33910209dbSNPEnsembl.1
Natural variantiVAR_003067132Q → P in Shangai; unstable. Corresponds to variant rs33950778dbSNPEnsembl.1
Natural variantiVAR_003068132Q → R in Sarrebourg; unstable. Corresponds to variant rs33950778dbSNPEnsembl.1
Natural variantiVAR_003069133K → N in Yamagata; O(2) affinity down. Corresponds to variant rs33946775dbSNPEnsembl.1
Natural variantiVAR_003070133K → Q in K-Woolwich. Corresponds to variant rs33953406dbSNPEnsembl.1
Natural variantiVAR_003071134V → L in Extredemura. Corresponds to variant rs34095019dbSNPEnsembl.1
Natural variantiVAR_003072135V → E in North Shore-Caracas; unstable. 1 PublicationCorresponds to variant rs33966761dbSNPEnsembl.1
Natural variantiVAR_003073136A → E in Beckman; O(2) affinity down; unstable. 1
Natural variantiVAR_003074136A → P in Altdorf; O(2) affinity up; unstable. Corresponds to variant rs35492035dbSNPEnsembl.1
Natural variantiVAR_003075137G → D in Hope; O(2) affinity down; unstable. Corresponds to variant rs33949486dbSNPEnsembl.1
Natural variantiVAR_003076139A → P in Brockton; unstable. Corresponds to variant rs33919821dbSNPEnsembl.1
Natural variantiVAR_003077140N → D in Geelong; unstable. 1 PublicationCorresponds to variant rs33910475dbSNPEnsembl.1
Natural variantiVAR_003078140N → K in Hinsdale; O(2) affinity down. 1 PublicationCorresponds to variant rs34240441dbSNPEnsembl.1
Natural variantiVAR_025335140N → S in S-Wake; associated with V-6. 1 Publication1
Natural variantiVAR_003079140N → Y in Aurora; O(2) affinity up. 1 PublicationCorresponds to variant rs33910475dbSNPEnsembl.1
Natural variantiVAR_003080141A → D in Himeji; unstable; O(2) affinity down. 1 PublicationCorresponds to variant rs33927093dbSNPEnsembl.1
Natural variantiVAR_003081141A → T in St Jacques; O(2) affinity up. Corresponds to variant rs34980264dbSNPEnsembl.1
Natural variantiVAR_003082141A → V in Puttelange; polycythemia; O(2) affinity up. 1 PublicationCorresponds to variant rs33927093dbSNPEnsembl.1
Natural variantiVAR_003083142L → R in Olmsted; unstable. Corresponds to variant rs35854892dbSNPEnsembl.1
Natural variantiVAR_003084143A → D in Ohio; O(2) affinity up. Corresponds to variant rs33921821dbSNPEnsembl.1
Natural variantiVAR_003085144H → D in Rancho Mirage. Corresponds to variant rs33929415dbSNPEnsembl.1
Natural variantiVAR_003087144H → P in Syracuse; O(2) affinity up. Corresponds to variant rs33918338dbSNPEnsembl.1
Natural variantiVAR_003086144H → Q in Little Rock; O(2) affinity up. Corresponds to variant rs36020563dbSNPEnsembl.1
Natural variantiVAR_003088144H → R in Abruzzo; O(2) affinity up. Corresponds to variant rs33918338dbSNPEnsembl.1
Natural variantiVAR_003089145K → E in Mito; O(2) affinity up. Corresponds to variant rs33964352dbSNPEnsembl.1
Natural variantiVAR_003090146Y → C in Rainier; O(2) affinity up. Corresponds to variant rs35117167dbSNPEnsembl.1
Natural variantiVAR_003091146Y → H in Bethesda; O(2) affinity up. Corresponds to variant rs33949869dbSNPEnsembl.1
Natural variantiVAR_003092147H → D in Hiroshima; O(2) affinity up. Corresponds to variant rs33961444dbSNPEnsembl.1
Natural variantiVAR_003093147H → L in Cowtown; O(2) affinity up. Corresponds to variant rs33954264dbSNPEnsembl.1
Natural variantiVAR_003094147H → P in York; O(2) affinity up. Corresponds to variant rs33954264dbSNPEnsembl.1
Natural variantiVAR_003095147H → Q in Kodaira; O(2) affinity up. 1 PublicationCorresponds to variant rs33985739dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25079 mRNA. Translation: AAA35597.1.
V00499 Genomic DNA. Translation: CAA23758.1.
DQ126270 Genomic DNA. Translation: AAZ39745.1.
DQ126271 Genomic DNA. Translation: AAZ39746.1.
DQ126272 Genomic DNA. Translation: AAZ39747.1.
DQ126273 Genomic DNA. Translation: AAZ39748.1.
DQ126274 Genomic DNA. Translation: AAZ39749.1.
DQ126275 Genomic DNA. Translation: AAZ39750.1.
DQ126276 Genomic DNA. Translation: AAZ39751.1.
DQ126277 Genomic DNA. Translation: AAZ39752.1.
DQ126278 Genomic DNA. Translation: AAZ39753.1.
DQ126279 Genomic DNA. Translation: AAZ39754.1.
DQ126280 Genomic DNA. Translation: AAZ39755.1.
DQ126281 Genomic DNA. Translation: AAZ39756.1.
DQ126282 Genomic DNA. Translation: AAZ39757.1.
DQ126283 Genomic DNA. Translation: AAZ39758.1.
DQ126284 Genomic DNA. Translation: AAZ39759.1.
DQ126285 Genomic DNA. Translation: AAZ39760.1.
DQ126286 Genomic DNA. Translation: AAZ39761.1.
DQ126287 Genomic DNA. Translation: AAZ39762.1.
DQ126288 Genomic DNA. Translation: AAZ39763.1.
DQ126289 Genomic DNA. Translation: AAZ39764.1.
DQ126290 Genomic DNA. Translation: AAZ39765.1.
DQ126291 Genomic DNA. Translation: AAZ39766.1.
DQ126292 Genomic DNA. Translation: AAZ39767.1.
DQ126293 Genomic DNA. Translation: AAZ39768.1.
DQ126294 Genomic DNA. Translation: AAZ39769.1.
DQ126295 Genomic DNA. Translation: AAZ39770.1.
DQ126296 Genomic DNA. Translation: AAZ39771.1.
DQ126297 Genomic DNA. Translation: AAZ39772.1.
DQ126298 Genomic DNA. Translation: AAZ39773.1.
DQ126299 Genomic DNA. Translation: AAZ39774.1.
DQ126300 Genomic DNA. Translation: AAZ39775.1.
DQ126301 Genomic DNA. Translation: AAZ39776.1.
DQ126302 Genomic DNA. Translation: AAZ39777.1.
DQ126303 Genomic DNA. Translation: AAZ39778.1.
DQ126304 Genomic DNA. Translation: AAZ39779.1.
DQ126305 Genomic DNA. Translation: AAZ39780.1.
DQ126306 Genomic DNA. Translation: AAZ39781.1.
DQ126307 Genomic DNA. Translation: AAZ39782.1.
DQ126308 Genomic DNA. Translation: AAZ39783.1.
DQ126309 Genomic DNA. Translation: AAZ39784.1.
DQ126310 Genomic DNA. Translation: AAZ39785.1.
DQ126311 Genomic DNA. Translation: AAZ39786.1.
DQ126312 Genomic DNA. Translation: AAZ39787.1.
DQ126313 Genomic DNA. Translation: AAZ39788.1.
DQ126314 Genomic DNA. Translation: AAZ39789.1.
DQ126315 Genomic DNA. Translation: AAZ39790.1.
DQ126316 Genomic DNA. Translation: AAZ39791.1.
DQ126317 Genomic DNA. Translation: AAZ39792.1.
DQ126318 Genomic DNA. Translation: AAZ39793.1.
DQ126319 Genomic DNA. Translation: AAZ39794.1.
DQ126320 Genomic DNA. Translation: AAZ39795.1.
DQ126321 Genomic DNA. Translation: AAZ39796.1.
DQ126322 Genomic DNA. Translation: AAZ39797.1.
DQ126323 Genomic DNA. Translation: AAZ39798.1.
DQ126324 Genomic DNA. Translation: AAZ39799.1.
DQ126325 Genomic DNA. Translation: AAZ39800.1.
AF007546 Genomic DNA. Translation: AAB62944.1.
AF083883 Genomic DNA. Translation: AAL68978.1.
AF117710 mRNA. Translation: AAD19696.1.
AF181989 mRNA. Translation: AAF00489.1.
AF349114 mRNA. Translation: AAK29639.1.
AF527577 Genomic DNA. Translation: AAM92001.1.
AY136510 mRNA. Translation: AAN11320.1.
AY163866 Genomic DNA. Translation: AAN84548.1.
AY260740 Genomic DNA. Translation: AAP21062.1.
AY509193 mRNA. Translation: AAR96398.1.
EF450778 Genomic DNA. Translation: ABO36678.1.
EU694432 mRNA. Translation: ACD39349.1.
AK311825 mRNA. Translation: BAG34767.1.
CR536530 mRNA. Translation: CAG38767.1.
CR541913 mRNA. Translation: CAG46711.1.
CH471064 Genomic DNA. Translation: EAW68806.1.
BC007075 mRNA. Translation: AAH07075.1.
U01317 Genomic DNA. Translation: AAA16334.1.
V00497 mRNA. Translation: CAA23756.1.
V00500 mRNA. Translation: CAA23759.1. Sequence problems.
L26462 Genomic DNA. Translation: AAA21100.1.
L26463 Genomic DNA. Translation: AAA21101.1.
L26464 Genomic DNA. Translation: AAA21102.1.
L26465 Genomic DNA. Translation: AAA21103.1.
L26466 Genomic DNA. Translation: AAA21104.1.
L26467 Genomic DNA. Translation: AAA21105.1.
L26468 Genomic DNA. Translation: AAA21106.1.
L26469 Genomic DNA. Translation: AAA21107.1.
L26470 Genomic DNA. Translation: AAA21108.1.
L26471 Genomic DNA. Translation: AAA21109.1.
L26472 Genomic DNA. Translation: AAA21110.1.
L26473 Genomic DNA. Translation: AAA21111.1.
L26474 Genomic DNA. Translation: AAA21112.1.
L26475 Genomic DNA. Translation: AAA21113.1.
L26476 Genomic DNA. Translation: AAA21114.1.
L26477 Genomic DNA. Translation: AAA21115.1.
L26478 Genomic DNA. Translation: AAA21116.1.
L48213 Genomic DNA. Translation: AAA88063.1.
L48214 Genomic DNA. Translation: AAA88061.1.
L48215 Genomic DNA. Translation: AAA88059.1.
L48216 Genomic DNA. Translation: AAA88065.1.
L48217 Genomic DNA. Translation: AAA88067.1.
M36640 Genomic DNA. Translation: AAA52634.1.
M11428 mRNA. Translation: AAA52633.1.
M25113 mRNA. Translation: AAA35966.1.
L48932 Genomic DNA. Translation: AAA88054.1.
CCDSiCCDS7753.1.
PIRiA53136. HBHU.
RefSeqiNP_000509.1. NM_000518.4.
UniGeneiHs.523443.

Genome annotation databases

EnsembliENST00000335295; ENSP00000333994; ENSG00000244734.
GeneIDi3043.
KEGGihsa:3043.
UCSCiuc001mae.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

HbVar

Human hemoglobin variants and thalassemias

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Hemoglobin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25079 mRNA. Translation: AAA35597.1.
V00499 Genomic DNA. Translation: CAA23758.1.
DQ126270 Genomic DNA. Translation: AAZ39745.1.
DQ126271 Genomic DNA. Translation: AAZ39746.1.
DQ126272 Genomic DNA. Translation: AAZ39747.1.
DQ126273 Genomic DNA. Translation: AAZ39748.1.
DQ126274 Genomic DNA. Translation: AAZ39749.1.
DQ126275 Genomic DNA. Translation: AAZ39750.1.
DQ126276 Genomic DNA. Translation: AAZ39751.1.
DQ126277 Genomic DNA. Translation: AAZ39752.1.
DQ126278 Genomic DNA. Translation: AAZ39753.1.
DQ126279 Genomic DNA. Translation: AAZ39754.1.
DQ126280 Genomic DNA. Translation: AAZ39755.1.
DQ126281 Genomic DNA. Translation: AAZ39756.1.
DQ126282 Genomic DNA. Translation: AAZ39757.1.
DQ126283 Genomic DNA. Translation: AAZ39758.1.
DQ126284 Genomic DNA. Translation: AAZ39759.1.
DQ126285 Genomic DNA. Translation: AAZ39760.1.
DQ126286 Genomic DNA. Translation: AAZ39761.1.
DQ126287 Genomic DNA. Translation: AAZ39762.1.
DQ126288 Genomic DNA. Translation: AAZ39763.1.
DQ126289 Genomic DNA. Translation: AAZ39764.1.
DQ126290 Genomic DNA. Translation: AAZ39765.1.
DQ126291 Genomic DNA. Translation: AAZ39766.1.
DQ126292 Genomic DNA. Translation: AAZ39767.1.
DQ126293 Genomic DNA. Translation: AAZ39768.1.
DQ126294 Genomic DNA. Translation: AAZ39769.1.
DQ126295 Genomic DNA. Translation: AAZ39770.1.
DQ126296 Genomic DNA. Translation: AAZ39771.1.
DQ126297 Genomic DNA. Translation: AAZ39772.1.
DQ126298 Genomic DNA. Translation: AAZ39773.1.
DQ126299 Genomic DNA. Translation: AAZ39774.1.
DQ126300 Genomic DNA. Translation: AAZ39775.1.
DQ126301 Genomic DNA. Translation: AAZ39776.1.
DQ126302 Genomic DNA. Translation: AAZ39777.1.
DQ126303 Genomic DNA. Translation: AAZ39778.1.
DQ126304 Genomic DNA. Translation: AAZ39779.1.
DQ126305 Genomic DNA. Translation: AAZ39780.1.
DQ126306 Genomic DNA. Translation: AAZ39781.1.
DQ126307 Genomic DNA. Translation: AAZ39782.1.
DQ126308 Genomic DNA. Translation: AAZ39783.1.
DQ126309 Genomic DNA. Translation: AAZ39784.1.
DQ126310 Genomic DNA. Translation: AAZ39785.1.
DQ126311 Genomic DNA. Translation: AAZ39786.1.
DQ126312 Genomic DNA. Translation: AAZ39787.1.
DQ126313 Genomic DNA. Translation: AAZ39788.1.
DQ126314 Genomic DNA. Translation: AAZ39789.1.
DQ126315 Genomic DNA. Translation: AAZ39790.1.
DQ126316 Genomic DNA. Translation: AAZ39791.1.
DQ126317 Genomic DNA. Translation: AAZ39792.1.
DQ126318 Genomic DNA. Translation: AAZ39793.1.
DQ126319 Genomic DNA. Translation: AAZ39794.1.
DQ126320 Genomic DNA. Translation: AAZ39795.1.
DQ126321 Genomic DNA. Translation: AAZ39796.1.
DQ126322 Genomic DNA. Translation: AAZ39797.1.
DQ126323 Genomic DNA. Translation: AAZ39798.1.
DQ126324 Genomic DNA. Translation: AAZ39799.1.
DQ126325 Genomic DNA. Translation: AAZ39800.1.
AF007546 Genomic DNA. Translation: AAB62944.1.
AF083883 Genomic DNA. Translation: AAL68978.1.
AF117710 mRNA. Translation: AAD19696.1.
AF181989 mRNA. Translation: AAF00489.1.
AF349114 mRNA. Translation: AAK29639.1.
AF527577 Genomic DNA. Translation: AAM92001.1.
AY136510 mRNA. Translation: AAN11320.1.
AY163866 Genomic DNA. Translation: AAN84548.1.
AY260740 Genomic DNA. Translation: AAP21062.1.
AY509193 mRNA. Translation: AAR96398.1.
EF450778 Genomic DNA. Translation: ABO36678.1.
EU694432 mRNA. Translation: ACD39349.1.
AK311825 mRNA. Translation: BAG34767.1.
CR536530 mRNA. Translation: CAG38767.1.
CR541913 mRNA. Translation: CAG46711.1.
CH471064 Genomic DNA. Translation: EAW68806.1.
BC007075 mRNA. Translation: AAH07075.1.
U01317 Genomic DNA. Translation: AAA16334.1.
V00497 mRNA. Translation: CAA23756.1.
V00500 mRNA. Translation: CAA23759.1. Sequence problems.
L26462 Genomic DNA. Translation: AAA21100.1.
L26463 Genomic DNA. Translation: AAA21101.1.
L26464 Genomic DNA. Translation: AAA21102.1.
L26465 Genomic DNA. Translation: AAA21103.1.
L26466 Genomic DNA. Translation: AAA21104.1.
L26467 Genomic DNA. Translation: AAA21105.1.
L26468 Genomic DNA. Translation: AAA21106.1.
L26469 Genomic DNA. Translation: AAA21107.1.
L26470 Genomic DNA. Translation: AAA21108.1.
L26471 Genomic DNA. Translation: AAA21109.1.
L26472 Genomic DNA. Translation: AAA21110.1.
L26473 Genomic DNA. Translation: AAA21111.1.
L26474 Genomic DNA. Translation: AAA21112.1.
L26475 Genomic DNA. Translation: AAA21113.1.
L26476 Genomic DNA. Translation: AAA21114.1.
L26477 Genomic DNA. Translation: AAA21115.1.
L26478 Genomic DNA. Translation: AAA21116.1.
L48213 Genomic DNA. Translation: AAA88063.1.
L48214 Genomic DNA. Translation: AAA88061.1.
L48215 Genomic DNA. Translation: AAA88059.1.
L48216 Genomic DNA. Translation: AAA88065.1.
L48217 Genomic DNA. Translation: AAA88067.1.
M36640 Genomic DNA. Translation: AAA52634.1.
M11428 mRNA. Translation: AAA52633.1.
M25113 mRNA. Translation: AAA35966.1.
L48932 Genomic DNA. Translation: AAA88054.1.
CCDSiCCDS7753.1.
PIRiA53136. HBHU.
RefSeqiNP_000509.1. NM_000518.4.
UniGeneiHs.523443.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A00X-ray2.00B/D