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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi156 – 163ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Name:dnaAUniRule annotation
Ordered Locus Names:SAV0001
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001142591 – 453Chromosomal replication initiator protein DnaAAdd BLAST453

Proteomic databases

PaxDbiP68865
PRIDEiP68865

2D gel databases

World-2DPAGEi0002:P68865

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV0001

Structurei

3D structure databases

ProteinModelPortaliP68865
SMRiP68865
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI4 Bacteria
COG0593 LUCA
HOGENOMiHOG000235658
KOiK02313
OMAiREFNPLF
PhylomeDBiP68865

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR024633 DnaA_N_dom
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PF11638 DnaA_N, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

P68865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKEIWEKV LEIAQEKLSA VSYSTFLKDT ELYTIKDGEA IVLSSIPFNA
60 70 80 90 100
NWLNQQYAEI IQAILFDVVG YEVKPHFITT EELANYSNNE TATPKETTKP
110 120 130 140 150
STETTEDNHV LGREQFNAHN TFDTFVIGPG NRFPHAASLA VAEAPAKAYN
160 170 180 190 200
PLFIYGGVGL GKTHLMHAIG HHVLDNNPDA KVIYTSSEKF TNEFIKSIRD
210 220 230 240 250
NEGEAFRERY RNIDVLLIDD IQFIQNKVQT QEEFFYTFNE LHQNNKQIVI
260 270 280 290 300
SSDRPPKEIA QLEDRLRSRF EWGLIVDITP PDYETRMAIL QKKIEEEKLD
310 320 330 340 350
IPPEALNYIA NQIQSNIREL EGALTRLLAY SQLLGKPITT ELTAEALKDI
360 370 380 390 400
IQAPKSKKIT IQDIQKIVGQ YYNVRIEDFS AKKRTKSIAY PRQIAMYLSR
410 420 430 440 450
ELTDFSLPKI GEEFGGRDHT TVIHAHEKIS KDLKEDPIFK QEVENLEKEI

RNV
Length:453
Mass (Da):51,966
Last modified:December 21, 2004 - v1
Checksum:iFD182A5E25F9ABD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB56163.1
RefSeqiWP_001290433.1, NC_002758.2

Genome annotation databases

EnsemblBacteriaiBAB56163; BAB56163; SAV0001
KEGGisav:SAV0001

Similar proteinsi

Entry informationi

Entry nameiDNAA_STAAM
AccessioniPrimary (citable) accession number: P68865
Secondary accession number(s): P49994
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health