Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P68831 (B2_FHV) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein B2
Gene names
Name:B2
OrganismFlock house virus (FHV)
Taxonomic identifier12287 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeAlphanodavirus
Virus hostCostelytra zealandica [TaxID: 50579]
Galleria mellonella (Greater wax moth) [TaxID: 7137]
Hordeum vulgare (Barley) [TaxID: 4513]
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932]

Protein attributes

Sequence length106 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response. Ref.2 Ref.3

Subunit structure

Homodimer. Ref.3

Developmental stage

Expressed at high levels early in the viral replication cycle.

Domain

The dsRNA-binding region is required for suppression of RNA silencing.

Miscellaneous

Encoded on a subgenomic RNA (RNA3) synthesized during replication and which is co-terminal with RNA1.

Sequence similarities

Belongs to the nodaviridae B2 protein family.

Ontologies

Keywords
   LigandRNA-binding
   Molecular functionSuppressor of RNA silencing
   Technical term3D-structure
Gene Ontology (GO)
   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 106106Protein B2
PRO_0000222454

Regions

Region1 – 7373RNA-binding

Secondary structure

............. 106
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P68831 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: FA79D28C4AB99CA9

FASTA10611,646
        10         20         30         40         50         60 
MPSKLALIQE LPDRIQTAVE AAMGMSYQDA PNNVRRDLDN LHACLNKAKL TVSRMVTSLL 

        70         80         90        100 
EKPSVVAYLE GKAPEEAKPT LEERLRKLEL SHSLPTTGSD PPPAKL 

« Hide

References

[1]"Near identity in the polymerase gene of two serologically distinct nodaviruses."
Dasgupta R.
Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing."
Li W.-X., Li H., Lu R., Li F., Dus M., Atkinson P., Brydon E.W.A., Johnson K.L., Garcia-Sastre A., Ball L.A., Palese P., Ding S.-W.
Proc. Natl. Acad. Sci. U.S.A. 101:1350-1355(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[3]"Dual modes of RNA-silencing suppression by Flock House virus protein B2."
Chao J.A., Lee J.H., Chapados B.R., Debler E.W., Schneemann A., Williamson J.R.
Nat. Struct. Mol. Biol. 12:952-957(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, RNA-BINDING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X77156 Genomic RNA. Translation: CAA54401.1.
PIRS41398.
RefSeqNP_689446.1. NC_004146.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2AZ0X-ray2.60A/B1-73[»]
2AZ2X-ray2.60A/B1-73[»]
2B9ZNMR-A/B1-72[»]
ProteinModelPortalP68831.
SMRP68831. Positions 2-72.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60497N.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1724847.

Family and domain databases

InterProIPR024377. RNA-bd_B2.
[Graphical view]
PfamPF11473. B2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP68831.

Entry information

Entry nameB2_FHV
AccessionPrimary (citable) accession number: P68831
Secondary accession number(s): P29100, Q89618, Q96632
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: January 22, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references