true2004-12-212023-09-1341B2_BBVSequence of the black beetle virus subgenomic RNA and its location in the viral genome.Guarino L.A.Ghosh A.Dasmahapatra B.Dasgupta R.Kaesberg P.doi:10.1016/0042-6822(84)90342-81984Virology139199-203NUCLEOTIDE SEQUENCE [GENOMIC RNA]Structure of the black beetle virus genome and its functional implications.Dasmahapatra B.Dasgupta R.Ghosh A.Kaesberg P.doi:10.1016/0022-2836(85)90337-71985J. Mol. Biol.182183-189NUCLEOTIDE SEQUENCE [GENOMIC RNA]QQBBB2ESAT-6-likeRNA-bd_B2RNA-bd_B2_sfB2FHV B2 protein-likeProtein B2B2Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.Homodimer. Interacts with RNA-directed RNA polymerase.Expressed at high levels early in the viral replication cycle.The dsRNA-binding region is required for suppression of RNA silencing. The N-terminus is involved in homodimerization. The alpha2 helices of the dimer bind parallel to the stem of the dsRNA helix.Encoded on a subgenomic RNA (RNA3) synthesized during replication and which is co-terminal with RNA1.Belongs to the nodaviridae B2 protein family.Protein B2116461106RNA-binding73P142004-12-21111646f3e308f183331f86a231dcec8406d4c4MPSKLALIQELPDRIQTAVEAAMGMSYQDAPNNVRRDLDNLHACLNKAKLTVSRMVTSLLEKPSVVAYLEGKAPEEAKPTLEERLRKLELSHSLPTTGSDPPPAKLtruetruetrue