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Protein

Protein B2

Gene

B2

Organism
Black beetle virus (BBV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Suppressor of RNA silencing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein B2
Gene namesi
Name:B2
OrganismiBlack beetle virus (BBV)
Taxonomic identifieri12285 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeAlphanodavirus
Virus hostiHeteronychus arator [TaxID: 295550]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106Protein B2PRO_0000222453Add
BLAST

Expressioni

Developmental stagei

Expressed at high levels early in the viral replication cycle.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP68830.
SMRiP68830. Positions 2-72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7373RNA-bindingBy similarityAdd
BLAST

Domaini

The dsRNA-binding region is required for suppression of RNA silencing.By similarity

Sequence similaritiesi

Belongs to the nodaviridae B2 protein family.Curated

Family and domain databases

InterProiIPR024377. RNA-bd_B2.
[Graphical view]
PfamiPF11473. B2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P68830-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSKLALIQE LPDRIQTAVE AAMGMSYQDA PNNVRRDLDN LHACLNKAKL
60 70 80 90 100
TVSRMVTSLL EKPSVVAYLE GKAPEEAKPT LEERLRKLEL SHSLPTTGSD

PPPAKL
Length:106
Mass (Da):11,646
Last modified:December 21, 2004 - v1
Checksum:iFA79D28C4AB99CA9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141R → P in AAA42746. (PubMed:6495657)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33065 Genomic RNA. Translation: AAA42746.1.
X02396 Genomic RNA. Translation: CAA26240.1.
PIRiB23243. QQBBB2.
RefSeqiYP_227598.1. NC_001411.2.

Genome annotation databases

GeneIDi956651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33065 Genomic RNA. Translation: AAA42746.1.
X02396 Genomic RNA. Translation: CAA26240.1.
PIRiB23243. QQBBB2.
RefSeqiYP_227598.1. NC_001411.2.

3D structure databases

ProteinModelPortaliP68830.
SMRiP68830. Positions 2-72.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi956651.

Family and domain databases

InterProiIPR024377. RNA-bd_B2.
[Graphical view]
PfamiPF11473. B2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence of the black beetle virus subgenomic RNA and its location in the viral genome."
    Guarino L.A., Ghosh A., Dasmahapatra B., Dasgupta R., Kaesberg P.
    Virology 139:199-203(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Structure of the black beetle virus genome and its functional implications."
    Dasmahapatra B., Dasgupta R., Ghosh A., Kaesberg P.
    J. Mol. Biol. 182:183-189(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiB2_BBV
AccessioniPrimary (citable) accession number: P68830
Secondary accession number(s): P29100, Q89618, Q96632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 1, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Encoded on a subgenomic RNA (RNA3) synthesized during replication and which is co-terminal with RNA1.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.