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P68830

- B2_BBV

UniProt

P68830 - B2_BBV

Protein

Protein B2

Gene

B2

Organism
Black beetle virus (BBV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Suppressor of RNA silencing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein B2
    Gene namesi
    Name:B2
    OrganismiBlack beetle virus (BBV)
    Taxonomic identifieri12285 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeAlphanodavirus
    Virus hostiHeteronychus arator [TaxID: 295550]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 106106Protein B2PRO_0000222453Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed at high levels early in the viral replication cycle.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP68830.
    SMRiP68830. Positions 2-72.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 7373RNA-bindingBy similarityAdd
    BLAST

    Domaini

    The dsRNA-binding region is required for suppression of RNA silencing.By similarity

    Sequence similaritiesi

    Belongs to the nodaviridae B2 protein family.Curated

    Family and domain databases

    InterProiIPR024377. RNA-bd_B2.
    [Graphical view]
    PfamiPF11473. B2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P68830-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSKLALIQE LPDRIQTAVE AAMGMSYQDA PNNVRRDLDN LHACLNKAKL    50
    TVSRMVTSLL EKPSVVAYLE GKAPEEAKPT LEERLRKLEL SHSLPTTGSD 100
    PPPAKL 106
    Length:106
    Mass (Da):11,646
    Last modified:December 21, 2004 - v1
    Checksum:iFA79D28C4AB99CA9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141R → P in AAA42746. (PubMed:6495657)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33065 Genomic RNA. Translation: AAA42746.1.
    X02396 Genomic RNA. Translation: CAA26240.1.
    PIRiB23243. QQBBB2.
    RefSeqiYP_227598.1. NC_001411.2.

    Genome annotation databases

    GeneIDi956651.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M33065 Genomic RNA. Translation: AAA42746.1 .
    X02396 Genomic RNA. Translation: CAA26240.1 .
    PIRi B23243. QQBBB2.
    RefSeqi YP_227598.1. NC_001411.2.

    3D structure databases

    ProteinModelPortali P68830.
    SMRi P68830. Positions 2-72.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 956651.

    Family and domain databases

    InterProi IPR024377. RNA-bd_B2.
    [Graphical view ]
    Pfami PF11473. B2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of the black beetle virus subgenomic RNA and its location in the viral genome."
      Guarino L.A., Ghosh A., Dasmahapatra B., Dasgupta R., Kaesberg P.
      Virology 139:199-203(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Structure of the black beetle virus genome and its functional implications."
      Dasmahapatra B., Dasgupta R., Ghosh A., Kaesberg P.
      J. Mol. Biol. 182:183-189(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiB2_BBV
    AccessioniPrimary (citable) accession number: P68830
    Secondary accession number(s): P29100, Q89618, Q96632
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Encoded on a subgenomic RNA (RNA3) synthesized during replication and which is co-terminal with RNA1.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3