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P68830

- B2_BBV

UniProt

P68830 - B2_BBV

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Protein

Protein B2

Gene

B2

Organism
Black beetle virus (BBV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response By similarity.By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Suppressor of RNA silencing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein B2
Gene namesi
Name:B2
OrganismiBlack beetle virus (BBV)
Taxonomic identifieri12285 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeAlphanodavirus
Virus hostiHeteronychus arator [TaxID: 295550]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106Protein B2PRO_0000222453Add
BLAST

Expressioni

Developmental stagei

Expressed at high levels early in the viral replication cycle.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP68830.
SMRiP68830. Positions 2-72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7373RNA-bindingBy similarityAdd
BLAST

Domaini

The dsRNA-binding region is required for suppression of RNA silencing.By similarity

Sequence similaritiesi

Belongs to the nodaviridae B2 protein family.Curated

Family and domain databases

InterProiIPR024377. RNA-bd_B2.
[Graphical view]
PfamiPF11473. B2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P68830-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSKLALIQE LPDRIQTAVE AAMGMSYQDA PNNVRRDLDN LHACLNKAKL
60 70 80 90 100
TVSRMVTSLL EKPSVVAYLE GKAPEEAKPT LEERLRKLEL SHSLPTTGSD

PPPAKL
Length:106
Mass (Da):11,646
Last modified:December 21, 2004 - v1
Checksum:iFA79D28C4AB99CA9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141R → P in AAA42746. (PubMed:6495657)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33065 Genomic RNA. Translation: AAA42746.1.
X02396 Genomic RNA. Translation: CAA26240.1.
PIRiB23243. QQBBB2.
RefSeqiYP_227598.1. NC_001411.2.

Genome annotation databases

GeneIDi956651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M33065 Genomic RNA. Translation: AAA42746.1 .
X02396 Genomic RNA. Translation: CAA26240.1 .
PIRi B23243. QQBBB2.
RefSeqi YP_227598.1. NC_001411.2.

3D structure databases

ProteinModelPortali P68830.
SMRi P68830. Positions 2-72.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956651.

Family and domain databases

InterProi IPR024377. RNA-bd_B2.
[Graphical view ]
Pfami PF11473. B2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of the black beetle virus subgenomic RNA and its location in the viral genome."
    Guarino L.A., Ghosh A., Dasmahapatra B., Dasgupta R., Kaesberg P.
    Virology 139:199-203(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Structure of the black beetle virus genome and its functional implications."
    Dasmahapatra B., Dasgupta R., Ghosh A., Kaesberg P.
    J. Mol. Biol. 182:183-189(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiB2_BBV
AccessioniPrimary (citable) accession number: P68830
Secondary accession number(s): P29100, Q89618, Q96632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 1, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Encoded on a subgenomic RNA (RNA3) synthesized during replication and which is co-terminal with RNA1.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3