P68830 (B2_BBV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein B2

Gene names

Name:

B2

Organism

Black beetle virus (BBV)

Taxonomic identifier

12285 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Nodaviridae › Alphanodavirus

Virus host

Heteronychus arator [TaxID: 295550]

Protein attributes

Sequence length	106 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response By similarity.
Subunit structure	Homodimer By similarity.
Developmental stage	Expressed at high levels early in the viral replication cycle.
Domain	The dsRNA-binding region is required for suppression of RNA silencing By similarity.
Miscellaneous	Encoded on a subgenomic RNA (RNA3) synthesized during replication and which is co-terminal with RNA1.
Sequence similarities	Belongs to the nodaviridae B2 protein family.

Ontologies

Keywords
Ligand	RNA-binding
Molecular function	Suppressor of RNA silencing
Gene Ontology (GO)
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 106	106	Protein B2		PRO_0000222453
Regions
	Region	1 – 73	73	RNA-binding By similarity
Experimental info
	Sequence conflict	14	1	R → P in AAA42746. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P68830 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: FA79D28C4AB99CA9	FASTA	106	11,646
	10 20 30 40 50 60 MPSKLALIQE LPDRIQTAVE AAMGMSYQDA PNNVRRDLDN LHACLNKAKL TVSRMVTSLL 70 80 90 100 EKPSVVAYLE GKAPEEAKPT LEERLRKLEL SHSLPTTGSD PPPAKL

References

[1]	"Sequence of the black beetle virus subgenomic RNA and its location in the viral genome." Guarino L.A., Ghosh A., Dasmahapatra B., Dasgupta R., Kaesberg P. Virology 139:199-203(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]	"Structure of the black beetle virus genome and its functional implications." Dasmahapatra B., Dasgupta R., Ghosh A., Kaesberg P. J. Mol. Biol. 182:183-189(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M33065 Genomic RNA. Translation: AAA42746.1. X02396 Genomic RNA. Translation: CAA26240.1.
PIR	QQBBB2. B23243.
RefSeq	YP_227598.1. NC_001411.2.
3D structure databases
ProteinModelPortal	P68830.
SMR	P68830. Positions 2-72.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	956651.
Family and domain databases
InterPro	IPR024377. RNA-bd_B2. [Graphical view]
Pfam	PF11473. B2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B2_BBV

Accession

Primary (citable) accession number: P68830
Secondary accession number(s): P29100, Q89618, Q96632

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	April 3, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program