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P68830 (B2_BBV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein B2
Gene names
Name:B2
OrganismBlack beetle virus (BBV)
Taxonomic identifier12285 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeAlphanodavirus
Virus hostHeteronychus arator [TaxID: 295550]

Protein attributes

Sequence length106 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response By similarity.

Subunit structure

Homodimer By similarity.

Developmental stage

Expressed at high levels early in the viral replication cycle.

Domain

The dsRNA-binding region is required for suppression of RNA silencing By similarity.

Miscellaneous

Encoded on a subgenomic RNA (RNA3) synthesized during replication and which is co-terminal with RNA1.

Sequence similarities

Belongs to the nodaviridae B2 protein family.

Ontologies

Keywords
   LigandRNA-binding
   Molecular functionSuppressor of RNA silencing
Gene Ontology (GO)
   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 106106Protein B2
PRO_0000222453

Regions

Region1 – 7373RNA-binding By similarity

Experimental info

Sequence conflict141R → P in AAA42746. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P68830 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: FA79D28C4AB99CA9

FASTA10611,646
        10         20         30         40         50         60 
MPSKLALIQE LPDRIQTAVE AAMGMSYQDA PNNVRRDLDN LHACLNKAKL TVSRMVTSLL 

        70         80         90        100 
EKPSVVAYLE GKAPEEAKPT LEERLRKLEL SHSLPTTGSD PPPAKL 

« Hide

References

[1]"Sequence of the black beetle virus subgenomic RNA and its location in the viral genome."
Guarino L.A., Ghosh A., Dasmahapatra B., Dasgupta R., Kaesberg P.
Virology 139:199-203(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Structure of the black beetle virus genome and its functional implications."
Dasmahapatra B., Dasgupta R., Ghosh A., Kaesberg P.
J. Mol. Biol. 182:183-189(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M33065 Genomic RNA. Translation: AAA42746.1.
X02396 Genomic RNA. Translation: CAA26240.1.
PIRQQBBB2. B23243.
RefSeqYP_227598.1. NC_001411.2.

3D structure databases

ProteinModelPortalP68830.
SMRP68830. Positions 2-72.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID956651.

Family and domain databases

InterProIPR024377. RNA-bd_B2.
[Graphical view]
PfamPF11473. B2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB2_BBV
AccessionPrimary (citable) accession number: P68830
Secondary accession number(s): P29100, Q89618, Q96632
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: April 3, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families