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P68821

- PGK_STAAW

UniProt

P68821 - PGK_STAAW

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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei156 – 1561SubstrateBy similarity
Binding sitei206 – 2061ATPBy similarity
Binding sitei294 – 2941ATP; via carbonyl oxygenBy similarity
Binding sitei325 – 3251ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi352 – 3554ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-756-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:MW0735
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Phosphoglycerate kinasePRO_0000146007Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi196620.MW0735.

Structurei

3D structure databases

ProteinModelPortaliP68821.
SMRiP68821. Positions 2-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate bindingBy similarity
Regioni59 – 624Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
KOiK00927.
OMAiWEALDIG.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P68821-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKKIVSDLD LKGKTVLVRA DFNVPLKDGE ITNDNRIVQA LPTIQYIIEQ
60 70 80 90 100
GGKIVLFSHL GKVKEESDKA KLTLRPVAED LSKKLDKEVV FVPETRGEKL
110 120 130 140 150
EAAIKDLKEG DVLLVENTRY EDLDGKKESK NDPELGKYWA SLGDVFVNDA
160 170 180 190 200
FGTAHREHAS NVGISTHLET AAGFLMDKEI KFIGGVVNDP HKPVVAILGG
210 220 230 240 250
AKVSDKINVI KNLVNIADKI IIGGGMAYTF LKAQGKEIGI SLLEEDKIDF
260 270 280 290 300
AKDLLEKHGD KIVLPVDTKV AKEFSNDAKI TVVPSDSIPA DQEGMDIGPN
310 320 330 340 350
TVKLFADELE GAHTVVWNGP MGVFEFSNFA QGTIGVCKAI ANLKDAITII
360 370 380 390
GGGDSAAAAI SLGFENDFTH ISTGGGASLE YLEGKELPGI KAINNK
Length:396
Mass (Da):42,602
Last modified:December 21, 2004 - v1
Checksum:iC8383CFDBC5BF4EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB94600.1.
RefSeqiNP_645552.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB94600; BAB94600; BAB94600.
GeneIDi1002846.
KEGGisam:MW0735.
PATRICi19568024. VBIStaAur44266_0773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000033 Genomic DNA. Translation: BAB94600.1 .
RefSeqi NP_645552.1. NC_003923.1.

3D structure databases

ProteinModelPortali P68821.
SMRi P68821. Positions 2-396.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196620.MW0735.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB94600 ; BAB94600 ; BAB94600 .
GeneIDi 1002846.
KEGGi sam:MW0735.
PATRICi 19568024. VBIStaAur44266_0773.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227108.
KOi K00927.
OMAi WEALDIG.
OrthoDBi EOG64N9Z0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci SAUR196620:GJ9Z-756-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiPGK_STAAW
AccessioniPrimary (citable) accession number: P68821
Secondary accession number(s): Q9Z5C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3