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Protein

Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C

Gene

gatC

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).By similarity

Catalytic activityi

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.
ATP + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + phosphate + L-asparaginyl-tRNA(Asn) + L-glutamate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-1956-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C (EC:6.3.5.-)
Short name:
Asp/Glu-ADT subunit C
Gene namesi
Name:gatC
Ordered Locus Names:SAV1901
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 100100Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit CPRO_0000105330Add
BLAST

Proteomic databases

PaxDbiP68807.

Interactioni

Subunit structurei

Heterotrimer of A, B and C subunits.By similarity

Protein-protein interaction databases

STRINGi158878.SAV1901.

Structurei

Secondary structure

1
100
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1510Combined sources
Helixi22 – 3918Combined sources
Helixi40 – 445Combined sources
Helixi74 – 785Combined sources
Beta strandi82 – 854Combined sources
Beta strandi88 – 925Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DF4X-ray3.20C1-100[»]
2DQNX-ray2.55C1-100[»]
2F2AX-ray2.30C1-100[»]
2G5HX-ray2.50C1-100[»]
2G5IX-ray3.35C1-100[»]
3IP4X-ray1.90C1-100[»]
ProteinModelPortaliP68807.
SMRiP68807. Positions 3-94.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68807.

Family & Domainsi

Sequence similaritiesi

Belongs to the GatC family.Curated

Phylogenomic databases

eggNOGiENOG4105VB5. Bacteria.
COG0721. LUCA.
HOGENOMiHOG000017523.
KOiK02435.
OMAiKVPQILG.
PhylomeDBiP68807.

Family and domain databases

HAMAPiMF_00122. GatC. 1 hit.
InterProiIPR003837. Asp/Glu-ADT_csu.
[Graphical view]
PfamiPF02686. Glu-tRNAGln. 1 hit.
[Graphical view]
SUPFAMiSSF141000. SSF141000. 1 hit.
TIGRFAMsiTIGR00135. gatC. 1 hit.

Sequencei

Sequence statusi: Complete.

P68807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVTREEVE HIANLARLQI SPEETEEMAN TLESILDFAK QNDSADTEGV
60 70 80 90 100
EPTYHVLDLQ NVLREDKAIK GIPQELALKN AKETEDGQFK VPTIMNEEDA
Length:100
Mass (Da):11,268
Last modified:December 21, 2004 - v1
Checksum:i7E9273A6AA979250
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58063.1.
RefSeqiWP_000170162.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58063; BAB58063; SAV1901.
KEGGisav:SAV1901.
PATRICi19564656. VBIStaAur52173_1968.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58063.1.
RefSeqiWP_000170162.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DF4X-ray3.20C1-100[»]
2DQNX-ray2.55C1-100[»]
2F2AX-ray2.30C1-100[»]
2G5HX-ray2.50C1-100[»]
2G5IX-ray3.35C1-100[»]
3IP4X-ray1.90C1-100[»]
ProteinModelPortaliP68807.
SMRiP68807. Positions 3-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV1901.

Proteomic databases

PaxDbiP68807.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58063; BAB58063; SAV1901.
KEGGisav:SAV1901.
PATRICi19564656. VBIStaAur52173_1968.

Phylogenomic databases

eggNOGiENOG4105VB5. Bacteria.
COG0721. LUCA.
HOGENOMiHOG000017523.
KOiK02435.
OMAiKVPQILG.
PhylomeDBiP68807.

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-1956-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP68807.

Family and domain databases

HAMAPiMF_00122. GatC. 1 hit.
InterProiIPR003837. Asp/Glu-ADT_csu.
[Graphical view]
PfamiPF02686. Glu-tRNAGln. 1 hit.
[Graphical view]
SUPFAMiSSF141000. SSF141000. 1 hit.
TIGRFAMsiTIGR00135. gatC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGATC_STAAM
AccessioniPrimary (citable) accession number: P68807
Secondary accession number(s): Q9RF08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.