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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. Forms a nonselective ion channel with a conductance of about 3 nanosiemens. May participate in the regulation of osmotic pressure changes within the cell.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channelUniRule annotation
Gene namesi
Name:mscLUniRule annotation
Ordered Locus Names:MW1235
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000418 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation1 Publication; Multi-pass membrane protein UniRule annotation1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14Cytoplasmic1 PublicationAdd BLAST14
Transmembranei15 – 43Helical1 PublicationAdd BLAST29
Topological domaini44 – 62Extracellular1 PublicationAdd BLAST19
Transmembranei63 – 82Helical1 PublicationAdd BLAST20
Topological domaini83 – 120Cytoplasmic1 PublicationAdd BLAST38

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001924661 – 120Large-conductance mechanosensitive channelAdd BLAST120

Interactioni

Subunit structurei

Homopentamer (By similarity). Can form a homotetramer (in vitro), but this may not be physiologically relevant (PubMed:19701184).UniRule annotationBy similarity1 Publication

Protein-protein interaction databases

DIPiDIP-59298N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HZQX-ray3.82A1-94[»]
ProteinModelPortaliP68806.
SMRiP68806.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68806.

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.UniRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000226782.
KOiK03282.
OMAiYGSFIQT.

Family and domain databases

HAMAPiMF_00115. MscL. 1 hit.
InterProiView protein in InterPro
IPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
PANTHERiPTHR30266:SF3. PTHR30266:SF3. 1 hit.
PfamiView protein in Pfam
PF01741. MscL. 1 hit.
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiView protein in PROSITE
PS01327. MSCL. 1 hit.

Sequencei

Sequence statusi: Complete.

P68806-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKEFKEFAL KGNVLDLAIA VVMGAAFNKI ISSLVENIIM PLIGKIFGSV
60 70 80 90 100
DFAKEWSFWG IKYGLFIQSV IDFIIIAFAL FIFVKIANTL MKKEEAEEEA
110 120
VVEENVVLLT EIRDLLREKK
Length:120
Mass (Da):13,616
Last modified:December 21, 2004 - v1
Checksum:iA4D1E6B2A7B7D2E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95100.1.
RefSeqiWP_000910489.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95100; BAB95100; BAB95100.
GeneIDi31214119.
KEGGisam:MW1235.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMSCL_STAAW
AccessioniPrimary (citable) accession number: P68806
Secondary accession number(s): O68285
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: July 5, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families