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Protein

Fibrinogen-binding protein

Gene

fib

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds to host fibrinogen.By similarity

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-1175-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen-binding protein
Gene namesi
Name:fib
Synonyms:efb
Ordered Locus Names:SAV1158
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929By similarityAdd
BLAST
Chaini30 – 165136Fibrinogen-binding proteinPRO_0000021258Add
BLAST

Proteomic databases

PaxDbiP68799.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV1158.

Structurei

Secondary structure

1
165
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi106 – 12419Combined sources
Helixi127 – 13913Combined sources
Helixi142 – 1443Combined sources
Helixi145 – 16117Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GOMX-ray1.25A/B105-165[»]
2GOXX-ray2.20B/D101-165[»]
ProteinModelPortaliP68799.
SMRiP68799. Positions 105-165.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68799.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000279984.
KOiK14200.
OMAiNKPAEKS.
OrthoDBiEOG6ND0JD.

Family and domain databases

InterProiIPR021033. Extracellular_fibrinogen-bd_C.
[Graphical view]
PfamiPF12199. efb-c. 1 hit.
[Graphical view]
SUPFAMiSSF158366. SSF158366. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68799-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKLIAKSL LTIAAIGITT TTIASTADAS EGYGPREKKP VSINHNIVEY
60 70 80 90 100
NDGTFKYQSR PKFNSTPKYI KFKHDYNILE FNDGTFEYGA RPQFNKPAAK
110 120 130 140 150
TDATIKKEQK LIQAQNLVRE FEKTHTVSAH RKAQKAVNLV SFEYKVKKMV
160
LQERIDNVLK QGLVR
Length:165
Mass (Da):18,793
Last modified:December 21, 2004 - v1
Checksum:iD885BF0138415D70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB57320.1.
RefSeqiWP_000791581.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB57320; BAB57320; SAV1158.
KEGGisav:SAV1158.
PATRICi19563015. VBIStaAur52173_1186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB57320.1.
RefSeqiWP_000791581.1. NC_002758.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GOMX-ray1.25A/B105-165[»]
2GOXX-ray2.20B/D101-165[»]
ProteinModelPortaliP68799.
SMRiP68799. Positions 105-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV1158.

Proteomic databases

PaxDbiP68799.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB57320; BAB57320; SAV1158.
KEGGisav:SAV1158.
PATRICi19563015. VBIStaAur52173_1186.

Phylogenomic databases

HOGENOMiHOG000279984.
KOiK14200.
OMAiNKPAEKS.
OrthoDBiEOG6ND0JD.

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-1175-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP68799.
PROiP68799.

Family and domain databases

InterProiIPR021033. Extracellular_fibrinogen-bd_C.
[Graphical view]
PfamiPF12199. efb-c. 1 hit.
[Graphical view]
SUPFAMiSSF158366. SSF158366. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.
  2. "A structural basis for complement inhibition by Staphylococcus aureus."
    Hammel M., Sfyroera G., Ricklin D., Magotti P., Lambris J.D., Geisbrecht B.V.
    Nat. Immunol. 8:430-437(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 105-165 AND OF 101-165 IN COMPLEX WITH C3D DOMAIN OF HUMAN COMPLEMENT C3 PROTEIN.

Entry informationi

Entry nameiFIB_STAAM
AccessioniPrimary (citable) accession number: P68799
Secondary accession number(s): Q08691
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: March 16, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.