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P68729 (ARGB_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetylglutamate kinase
EC=2.7.2.8
Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK
Gene names
Name:argB
Ordered Locus Names:BSU11210
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B

Subunit structure

Homodimer By similarity. HAMAP MF_00082_B

Subcellular location

Cytoplasm By similarity HAMAP MF_00082_B.

Sequence similarities

Belongs to the acetylglutamate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Acetylglutamate kinase HAMAP MF_00082_B
PRO_0000112587

Regions

Region41 – 422Substrate binding By similarity

Sites

Binding site631Substrate By similarity
Binding site1561Substrate By similarity
Site81Transition state stabilizer By similarity
Site2151Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
P68729 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: F5C71CD5985DCDA6

FASTA25827,724
        10         20         30         40         50         60 
MKKTIVFKCG GSVIRELSEE FYQNLKELRA SGWKLAIVHG GGPEITNMLK RLNIKTEFSG 

        70         80         90        100        110        120 
GQRKTTKPVL EVAEMVLSGS VNKFFVAELA KHGLRAAGIS GKDGGLLEAD YLDPETYGEV 

       130        140        150        160        170        180 
GEIKKVDASM VNALMENGII PVIAPLSMTS DCKTLNVNAD LAASAVAGAL EADKLMFVTD 

       190        200        210        220        230        240 
VDGIMKEKQR LDVLTPKEIQ MLIKQEVITG GMIPKVNSAL SALSDQVSEV MIVNGKGSFF 

       250 
AEQTFQGTKI VKAKEAVS

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of the citrulline biosynthetic operon argC-F from Bacillus subtilis."
O'Reilly M., Devine K.M.
Microbiology 140:1023-1025(1994) [PubMed: 8025667] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z26919 Genomic DNA. Translation: CAA81545.1.
AL009126 Genomic DNA. Translation: CAB12962.1.
PIRI40374.
RefSeqNP_389003.1. NC_000964.3.

3D structure databases

ProteinModelPortalP68729.
SMRP68729. Positions 3-254.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000000961; EBBACP00000000961; EBBACG00000000959.
GeneID936381.
GenomeReviewsGene locus BSU11210 in contig AL009126_GR.
KEGGbsu:BSU11210.
NMPDRfig|224308.1.peg.1122.
PATRIC18973952. VBIBacSub10457_1170.

Organism-specific databases

GenoListBSU11210. [Micado]

Phylogenomic databases

GeneTreeEBGT00050000001971.
HOGENOMHBG497643.
OMAGGCLVDD.
PhylomeDBP68729.
ProtClustDBPRK00942.

Enzyme and pathway databases

BioCycBSUB:BSU11210-MONOMER.

Family and domain databases

HAMAPMF_00082_B. ArgB_B.
[Tree]
InterProIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
[Graphical view]
Gene3DG3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KOK00930.
PfamPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000728. NAGK. 1 hit.
PRINTSPR00474. GLU5KINASE.
SUPFAMSSF53633. Aa_kinase. 1 hit.
TIGRFAMsTIGR00761. ArgB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARGB_BACSU
AccessionPrimary (citable) accession number: P68729
Secondary accession number(s): P36840
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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