Reviewed, UniProtKB/Swiss-Prot P68692 (GLRX1_VACCW)

Names and origin

Protein names

Recommended name:
    Glutaredoxin-1

Gene names

Ordered Locus Names:	VACWR069
ORF Names:	O2L

Organism

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))

Taxonomic identifier

10254 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus

Virus host

Bos taurus (Bovine) [TaxID: 9913]

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has thioltransferase and dehydroascorbate reductase activities.
Sequence similarities	Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Domain	Redox-active center
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 108	108	Glutaredoxin-1		PRO_0000141618
Regions
	Domain	3 – 106	104	Glutaredoxin
Amino acid modifications
	Disulfide bond	23 ↔ 26		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	P68692-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 8C754AE57D7F54D4	FASTA	108	12,355
	10 20 30 40 50 60 MAEEFVQQRL ANNKVTIFVK YTCPFCRNAL DILNKFSFKR GAYEIVDIKE FKPENELRDY 70 80 90 100 FEQITGGRTV PRIFFGKTSI GGYSDLLEID NMDALGDILS SIGVLRTC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Glutaredoxin homolog encoded by vaccinia virus is a virion-associated enzyme with thioltransferase and dehydroascorbate reductase activities." Ahn B.-Y., Moss B. Proc. Natl. Acad. Sci. U.S.A. 89:7060-7064(1992) [PubMed: 1496000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
[2]	"Sequencing of the coding region of Vaccinia-WR to an average 9-fold redundancy and an error rate of 0.16/10kb." Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J., Wohlhueter R. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M76472 Genomic DNA. Translation: AAA48249.1. AY243312 Genomic DNA. Translation: AAO89348.1.
PIR	E42510.
RefSeq	YP_232951.1.
3D structure databases
HSSP	HSSP built from PDB template 1JHB based on UniProtKB P35754.
SMR	P68692. Positions 1-107.
ModBase	Search...
Genome annotation databases
GeneID	3707602.
Family and domain databases
InterPro	IPR011767. GLR_AS. IPR002109. Glutaredoxin. IPR014025. Glutaredoxin_sub. IPR011899. GRX_euk. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PRINTS	PR00160. GLUTAREDOXIN.
TIGRFAMs	TIGR02180. GRX_euk. 1 hit.
PROSITE	PS00195. GLUTAREDOXIN_1. 1 hit. PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX1_VACCW

Accession

Primary (citable) accession number: P68692
Secondary accession number(s): P20818

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	December 7, 2004
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)