P68691 (GLRX1_VACCP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Glutaredoxin-1
Organism	Vaccinia virus (strain L-IVP) (VACV)
Taxonomic identifier	31531 [NCBI]
Taxonomic lineage	Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Vaccinia virus
Virus host	Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has thioltransferase and dehydroascorbate reductase activities.
Subcellular location	Virion. Note: Localizes to the virion core By similarity.
Sequence similarities	Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Virion
Domain	Redox-active center
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	virion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 108	108	Glutaredoxin-1		PRO_0000141616
Regions
	Domain	3 – 106	104	Glutaredoxin
Amino acid modifications
	Disulfide bond	23 ↔ 26		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	P68691 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 8C754AE57D7F54D4	FASTA	108	12,355
	10 20 30 40 50 60 MAEEFVQQRL ANNKVTIFVK YTCPFCRNAL DILNKFSFKR GAYEIVDIKE FKPENELRDY 70 80 90 100 FEQITGGRTV PRIFFGKTSI GGYSDLLEID NMDALGDILS SIGVLRTC

References

[1]

"Molecular-biological study of vaccinia virus genome. II. Localization and nucleotide sequence of vaccinia virus genes coding for proteins 36K and 12K." Riazankina O.I., Shchelkunov S.N., Muravlev A.I., Netesova N.A., Mikriukov N.N., Gutorov V.V., Nikulin A.E., Kulichkov V.A., Malygin E.G. Mol. Biol. (Mosk.) 24:968-976(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X61166 Genomic DNA. Translation: CAA43476.1.
PIR	E42510.
RefSeq	YP_232951.1. NC_006998.1.
3D structure databases
ProteinModelPortal	P68691.
SMR	P68691. Positions 1-107.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3707602.
Phylogenomic databases
ProtClustDB	PHA3050.
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR011767. GLR_AS. IPR002109. Glutaredoxin. IPR011899. Glutaredoxin_euk/vir. IPR014025. Glutaredoxin_subgr. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PRINTS	PR00160. GLUTAREDOXIN.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR02180. GRX_euk. 1 hit.
PROSITE	PS00195. GLUTAREDOXIN_1. 1 hit. PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX1_VACCP

Accession

Primary (citable) accession number: P68691
Secondary accession number(s): P20818

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	December 7, 2004
Last modified:	April 3, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program