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Protein

Glutaredoxin 1

Gene

grxA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfide bonds in a coupled system with glutathione reductase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDeoxyribonucleotide synthesis, Electron transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:RED-GLUTAREDOXIN
MetaCyc:RED-GLUTAREDOXIN
SABIO-RKP68688

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin 1
Short name:
Grx1
Gene namesi
Name:grxA
Synonyms:grx
Ordered Locus Names:b0849, JW0833
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10417 grxA

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001415811 – 85Glutaredoxin 1Add BLAST85

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi11 ↔ 14Redox-active

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP68688
PRIDEiP68688

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi4259990, 8 interactors
IntActiP68688, 16 interactors
STRINGi316385.ECDH10B_0919

Structurei

Secondary structure

185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Helixi13 – 28Combined sources16
Beta strandi32 – 36Combined sources5
Helixi38 – 41Combined sources4
Helixi46 – 51Combined sources6
Beta strandi61 – 64Combined sources4
Beta strandi67 – 72Combined sources6
Helixi73 – 84Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EGONMR-A1-85[»]
1EGRNMR-A1-85[»]
1GRXNMR-A1-85[»]
1QFNNMR-A1-85[»]
1UPYmodel-G1-85[»]
1UPZmodel-G1-85[»]
1UQ0model-G1-85[»]
1UQ1model-G1-85[»]
1UQ2model-G1-85[»]
1UQ3model-G1-85[»]
1UQ6model-G1-85[»]
1UQ7model-G1-85[»]
1UQHmodel-G1-85[»]
1UQNmodel-G1-85[»]
ProteinModelPortaliP68688
SMRiP68688
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68688

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 85GlutaredoxinPROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the glutaredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG41090BQ Bacteria
COG0695 LUCA
HOGENOMiHOG000095203
InParanoidiP68688
KOiK03674
OMAiVGGCTEF
PhylomeDBiP68688

Family and domain databases

InterProiView protein in InterPro
IPR011767 GLR_AS
IPR002109 Glutaredoxin
IPR014025 Glutaredoxin_subgr
IPR011902 GRXA
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PRINTSiPR00160 GLUTAREDOXIN
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02183 GRXA, 1 hit
PROSITEiView protein in PROSITE
PS00195 GLUTAREDOXIN_1, 1 hit
PS51354 GLUTAREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P68688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTVIFGRSG CPYCVRAKDL AEKLSNERDD FQYQYVDIRA EGITKEDLQQ
60 70 80
KAGKPVETVP QIFVDQQHIG GYTDFAAWVK ENLDA
Length:85
Mass (Da):9,685
Last modified:July 21, 1986 - v1
Checksum:i33C185A47021EF42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13449 Genomic DNA Translation: AAA23936.1
U18655 Genomic DNA Translation: AAC43449.1
U00096 Genomic DNA Translation: AAC73936.1
AP009048 Genomic DNA Translation: BAA35552.1
PIRiA00283 GDEC
RefSeqiNP_415370.1, NC_000913.3
WP_001195240.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73936; AAC73936; b0849
BAA35552; BAA35552; BAA35552
GeneIDi945479
KEGGiecj:JW0833
eco:b0849
PATRICifig|1411691.4.peg.1429

Similar proteinsi

Entry informationi

Entry nameiGLRX1_ECOLI
AccessioniPrimary (citable) accession number: P68688
Secondary accession number(s): P00277
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health