Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Viral interleukin-10 homolog

Gene

E7

Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Down-regulates the expression of the TAP1 gene (transporter associated with antigen processing), thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processEvasion of host immunity by viral interleukin-like protein, Host-virus interaction, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Viral interleukin-10 homolog
Short name:
vIL-10
Gene namesi
ORF Names:E7
OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
Taxonomic identifieri82831 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Proteomesi
  • UP000007083 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001537619 – 179Viral interleukin-10 homologAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 127By similarity
Disulfide bondi80 ↔ 133By similarity
Glycosylationi100N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP68678.
SMRiP68678.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK21533.
OrthoDBiVOG090000WI.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
PfamiView protein in Pfam
PF00726. IL10. 1 hit.
PRINTSiPR01294. INTRLEUKIN10.
SMARTiView protein in SMART
SM00188. IL10. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00520. INTERLEUKIN_10. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68678-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRASLLCCL VLLAGVWADN KYDSESGDDC PTLPTSLPHM LHELRAAFSR
60 70 80 90 100
VKTFFQMKDQ LDNMLLDGSL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN
110 120 130 140 150
HSTDQEKDKV NSLGEKLKTL RVRLRRCHRF LPCENKSKAV EQVKSAFSKL
160 170
QEKGVYKAMS EFDIFINYIE AYMTTKMKN
Length:179
Mass (Da):20,655
Last modified:December 7, 2004 - v1
Checksum:iF6516398F67B41F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20824 Genomic DNA. Translation: AAC13857.1.
PIRiA48558.
RefSeqiNP_042666.1. NC_001650.2.

Genome annotation databases

GeneIDi1461021.
KEGGivg:1461021.

Similar proteinsi

Entry informationi

Entry nameiIL10H_EHV2
AccessioniPrimary (citable) accession number: P68678
Secondary accession number(s): Q89451
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: September 27, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families