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Protein

Protein FixC

Gene

fixC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Could be part of an electron transfer system required for anaerobic carnitine reduction.

Cofactori

FADCurated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 2817FAD or NAD or NADPSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • carnitine metabolic process Source: EcoliWiki
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciEcoCyc:EG11564-MONOMER.
ECOL316407:JW0042-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FixC
Gene namesi
Name:fixC
Synonyms:yaaS
Ordered Locus Names:b0043, JW0042
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11564. fixC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Protein FixCPRO_0000200690Add
BLAST

Proteomic databases

PaxDbiP68644.
PRIDEiP68644.

Interactioni

Protein-protein interaction databases

BioGridi4262204. 7 interactions.
IntActiP68644. 8 interactions.
STRINGi511145.b0043.

Structurei

3D structure databases

ProteinModelPortaliP68644.
SMRiP68644. Positions 5-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETF-QO/FixC family.Curated

Phylogenomic databases

eggNOGiENOG4105DWH. Bacteria.
COG0644. LUCA.
HOGENOMiHOG000018936.
InParanoidiP68644.
KOiK00313.
OMAiFLLHTGV.
OrthoDBiEOG6716K7.
PhylomeDBiP68644.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR002938. FAD-bd.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

P68644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDIFDAII VGAGLAGSVA ALVLAREGAQ VLVIERGNSA GAKNVTGGRL
60 70 80 90 100
YAHSLEHIIP GFADSAPVER LITHEKLAFM TEKSAMTMDY CNGDETSPSQ
110 120 130 140 150
RSYSVLRSKF DAWLMEQAEE AGAQLITGIR VDNLVQRDGK VVGVEADGDV
160 170 180 190 200
IEAKTVILAD GVNSILAEKL GMAKRVKPTD VAVGVKELIE LPKSVIEDRF
210 220 230 240 250
QLQGNQGAAC LFAGSPTDGL MGGGFLYTNE NTLSLGLVCG LHHLHDAKKS
260 270 280 290 300
VPQMLEDFKQ HPAVAPLIAG GKLVEYSAHV VPEAGINMLP ELVGDGVLIA
310 320 330 340 350
GDAAGMCMNL GFTIRGMDLA IAAGEAAAKT VLSAMKSDDF SKQKLAEYRQ
360 370 380 390 400
HLESGPLRDM RMYQKLPAFL DNPRMFSGYP ELAVGVARDL FTIDGSAPEL
410 420
MRKKILRHGK KVGFINLIKD GMKGVTVL
Length:428
Mass (Da):45,703
Last modified:December 7, 2004 - v1
Checksum:i4D089EE9A30C7FBC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 33MSE → MT (PubMed:7473063).Curated
Sequence conflicti64 – 641D → E in CAA50799 (PubMed:1630901).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73154.1.
AP009048 Genomic DNA. Translation: BAB96611.2.
X71977 Genomic DNA. Translation: CAA50799.1.
PIRiC64725.
RefSeqiNP_414585.1. NC_000913.3.
WP_001287715.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73154; AAC73154; b0043.
BAB96611; BAB96611; BAB96611.
GeneIDi948958.
KEGGiecj:JW0042.
eco:b0043.
PATRICi32115185. VBIEscCol129921_0044.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73154.1.
AP009048 Genomic DNA. Translation: BAB96611.2.
X71977 Genomic DNA. Translation: CAA50799.1.
PIRiC64725.
RefSeqiNP_414585.1. NC_000913.3.
WP_001287715.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP68644.
SMRiP68644. Positions 5-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262204. 7 interactions.
IntActiP68644. 8 interactions.
STRINGi511145.b0043.

Proteomic databases

PaxDbiP68644.
PRIDEiP68644.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73154; AAC73154; b0043.
BAB96611; BAB96611; BAB96611.
GeneIDi948958.
KEGGiecj:JW0042.
eco:b0043.
PATRICi32115185. VBIEscCol129921_0044.

Organism-specific databases

EchoBASEiEB1525.
EcoGeneiEG11564. fixC.

Phylogenomic databases

eggNOGiENOG4105DWH. Bacteria.
COG0644. LUCA.
HOGENOMiHOG000018936.
InParanoidiP68644.
KOiK00313.
OMAiFLLHTGV.
OrthoDBiEOG6716K7.
PhylomeDBiP68644.

Enzyme and pathway databases

BioCyciEcoCyc:EG11564-MONOMER.
ECOL316407:JW0042-MONOMER.

Miscellaneous databases

PROiP68644.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR002938. FAD-bd.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region."
    Yura T., Mori H., Nagai H., Nagata T., Ishihama A., Fujita N., Isono K., Mizobuchi K., Nakata A.
    Nucleic Acids Res. 20:3305-3308(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO 64; 280 AND 310.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "The fix Escherichia coli region contains four genes related to carnitine metabolism."
    Eichler K., Buchet A., Bourgis F., Kleber H.-P., Mandrand-Berthelot M.-A.
    J. Basic Microbiol. 35:217-227(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-188.
    Strain: O44:K74.
  5. "The fixA and fixB genes are necessary for anaerobic carnitine reduction in Escherichia coli."
    Walt A., Kahn M.L.
    J. Bacteriol. 184:4044-4047(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROBABLE FUNCTION.
    Strain: K12 / BW25113.

Entry informationi

Entry nameiFIXC_ECOLI
AccessioniPrimary (citable) accession number: P68644
Secondary accession number(s): P31575, P75626
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: January 20, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.