Reviewed, UniProtKB/Swiss-Prot P68639 (VCP_VACCC)

Names and origin

Protein names

Recommended name:
    Complement control protein
Alternative name(s):
    VCP
    Secretory protein 35
      Short name=Protein C3
    28 kDa protein

Gene names

ORF Names:

C3L

Organism

Vaccinia virus (strain Copenhagen) (VACV) [Complete proteome]

Taxonomic identifier

10249 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serves to protect the virus against complement attack by inhibiting both classical and alternative pathways of complement activation. Binds C3b and C4b.
Sequence similarities	Belongs to the receptors of complement activation (RCA) family. Contains 4 Sushi (CCP/SCR) domains.

Ontologies

Keywords
Domain	Repeat Signal Sushi
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	negative regulation of complement activation Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	complement binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Chain	20 – 263	244	Complement control protein		PRO_0000006023
Regions
	Domain	20 – 83	64	Sushi 1
	Domain	84 – 145	62	Sushi 2
	Domain	146 – 203	58	Sushi 3
	Domain	204 – 263	60	Sushi 4
Amino acid modifications
	Disulfide bond	21 ↔ 70		By similarity
	Disulfide bond	54 ↔ 81		By similarity
	Disulfide bond	86 ↔ 126		By similarity
	Disulfide bond	112 ↔ 143		By similarity
	Disulfide bond	148 ↔ 190		By similarity
	Disulfide bond	176 ↔ 201		By similarity
	Disulfide bond	206 ↔ 248		By similarity
	Disulfide bond	234 ↔ 261		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P68639-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: E4322CC9A6EF8997	FASTA	263	28,629
	10 20 30 40 50 60 MKVESVTFLT LLGIGCVLSC CTIPSRPINM KFKNSVETDA NANYNIGDTI EYLCLPGYRK 70 80 90 100 110 120 QKMGPIYAKC TGTGWTLFNQ CIKRRCPSPR DIDNGQLDIG GVDFGSSITY SCNSGYHLIG 130 140 150 160 170 180 ESKSYCELGS TGSMVWNPEA PICESVKCQS PPSISNGRHN GYEDFYTDGS VVTYSCNSGY 190 200 210 220 230 240 SLIGNSGVLC SGGEWSDPPT CQIVKCPHPT ISNGYLSSGF KRSYSYNDNV DFKCKYGYKL 250 260 SGSSSSTCSP GNTWKPELPK CVR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete DNA sequence of vaccinia virus." Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E. Virology 179:247-266(1990) [PubMed: 2219722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Appendix to 'The complete DNA sequence of vaccinia virus'." Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E. Virology 179:517-563(1990) Cited for: COMPLETE GENOME.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M35027 Genomic DNA. Translation: AAA47997.1.
PIR	WMVZSP. A31005.
3D structure databases
SMR	P68639. Positions 20-262.
ModBase	Search...
Family and domain databases
InterPro	IPR011176. CIP_VAC_C3L. IPR016060. Complement_control_module. IPR000436. Sushi_SCR_CCP. [Graphical view]
Gene3D	G3DSA:2.10.70.10. Complement_control_module. 4 hits.
Pfam	PF00084. Sushi. 4 hits. [Graphical view]
PIRSF	PIRSF002486. CIP_VAC_C3L. 1 hit.
SMART	SM00032. CCP. 4 hits. [Graphical view]
PROSITE	PS50923. SUSHI. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VCP_VACCC

Accession

Primary (citable) accession number: P68639
Secondary accession number(s): P10998

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	December 7, 2004
Last modified:	March 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)