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Protein

Complement control protein C3

Gene

VACWR025

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serves to protect the virus against complement attack by inhibiting both classical and alternative pathways of complement activation. Binds C3b and C4b.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host complement factors by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Complement control protein C3
Alternative name(s):
28 kDa protein
Secretory protein 35
Short name:
Protein C3
VCP
Gene namesi
Ordered Locus Names:VACWR025
ORF Names:C3L
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Secreted, Virion

Pathology & Biotechi

Chemistry

DrugBankiDB04786. Suramin.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 263244Complement control protein C3PRO_0000006024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 – 20Interchain (with C-162 in protein A56)PROSITE-ProRule annotation
Disulfide bondi21 ↔ 70PROSITE-ProRule annotation
Disulfide bondi54 ↔ 81PROSITE-ProRule annotation
Disulfide bondi86 ↔ 126PROSITE-ProRule annotation
Disulfide bondi112 ↔ 143PROSITE-ProRule annotation
Disulfide bondi148 ↔ 190PROSITE-ProRule annotation
Disulfide bondi176 ↔ 201PROSITE-ProRule annotation
Disulfide bondi206 ↔ 248PROSITE-ProRule annotation
Disulfide bondi234 ↔ 261PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterodimer with A56 protein; disulfide-linked.

Protein-protein interaction databases

IntActiP68638. 1 interaction.
MINTiMINT-6740569.

Structurei

Secondary structure

1
263
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 303Combined sources
Beta strandi44 – 463Combined sources
Beta strandi65 – 717Combined sources
Beta strandi74 – 774Combined sources
Beta strandi96 – 994Combined sources
Beta strandi117 – 1204Combined sources
Beta strandi122 – 1243Combined sources
Beta strandi129 – 1324Combined sources
Beta strandi135 – 1384Combined sources
Beta strandi143 – 1464Combined sources
Beta strandi157 – 1593Combined sources
Beta strandi162 – 1654Combined sources
Beta strandi168 – 1725Combined sources
Beta strandi174 – 1763Combined sources
Beta strandi181 – 1833Combined sources
Beta strandi185 – 1884Combined sources
Beta strandi191 – 1933Combined sources
Beta strandi195 – 1973Combined sources
Beta strandi200 – 2034Combined sources
Beta strandi212 – 2165Combined sources
Beta strandi226 – 2316Combined sources
Beta strandi232 – 2343Combined sources
Beta strandi235 – 2373Combined sources
Beta strandi239 – 2424Combined sources
Beta strandi247 – 2493Combined sources
Turni250 – 2523Combined sources
Beta strandi253 – 2564Combined sources
Beta strandi260 – 2623Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G40X-ray2.20A/B20-263[»]
1G44X-ray2.60A/B/C20-263[»]
1RIDX-ray2.10A/B20-263[»]
1VVCNMR-A146-263[»]
1VVDNMR-A146-263[»]
1VVENMR-A146-263[»]
1Y8EX-ray2.20A/B20-263[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68638.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 8364Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini84 – 14562Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini146 – 20358Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini204 – 26360Sushi 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Family and domain databases

InterProiIPR011176. CIP_VAC_C3L.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 4 hits.
[Graphical view]
PIRSFiPIRSF002486. CIP_VAC_C3L. 1 hit.
SMARTiSM00032. CCP. 4 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 4 hits.
PROSITEiPS50923. SUSHI. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVESVTFLT LLGIGCVLSC CTIPSRPINM KFKNSVETDA NANYNIGDTI
60 70 80 90 100
EYLCLPGYRK QKMGPIYAKC TGTGWTLFNQ CIKRRCPSPR DIDNGQLDIG
110 120 130 140 150
GVDFGSSITY SCNSGYHLIG ESKSYCELGS TGSMVWNPEA PICESVKCQS
160 170 180 190 200
PPSISNGRHN GYEDFYTDGS VVTYSCNSGY SLIGNSGVLC SGGEWSDPPT
210 220 230 240 250
CQIVKCPHPT ISNGYLSSGF KRSYSYNDNV DFKCKYGYKL SGSSSSTCSP
260
GNTWKPELPK CVR
Length:263
Mass (Da):28,629
Last modified:December 7, 2004 - v1
Checksum:iE4322CC9A6EF8997
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13166 Genomic DNA. Translation: CAA31564.1.
M22812 Genomic DNA. Translation: AAA69605.1.
AY243312 Genomic DNA. Translation: AAO89304.1.
PIRiA31005. WMVZSP.
RefSeqiYP_232907.1. NC_006998.1.

Genome annotation databases

GeneIDi3707640.
KEGGivg:3707640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13166 Genomic DNA. Translation: CAA31564.1.
M22812 Genomic DNA. Translation: AAA69605.1.
AY243312 Genomic DNA. Translation: AAO89304.1.
PIRiA31005. WMVZSP.
RefSeqiYP_232907.1. NC_006998.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G40X-ray2.20A/B20-263[»]
1G44X-ray2.60A/B/C20-263[»]
1RIDX-ray2.10A/B20-263[»]
1VVCNMR-A146-263[»]
1VVDNMR-A146-263[»]
1VVENMR-A146-263[»]
1Y8EX-ray2.20A/B20-263[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP68638. 1 interaction.
MINTiMINT-6740569.

Chemistry

DrugBankiDB04786. Suramin.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3707640.
KEGGivg:3707640.

Miscellaneous databases

EvolutionaryTraceiP68638.

Family and domain databases

InterProiIPR011176. CIP_VAC_C3L.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 4 hits.
[Graphical view]
PIRSFiPIRSF002486. CIP_VAC_C3L. 1 hit.
SMARTiSM00032. CCP. 4 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 4 hits.
PROSITEiPS50923. SUSHI. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVCP_VACCW
AccessioniPrimary (citable) accession number: P68638
Secondary accession number(s): P10998, Q76ZY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: January 20, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.