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P68638 (VCP_VACCW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Complement control protein
Alternative name(s):
28 kDa protein
Secretory protein 35
Short name=Protein C3
VCP
Gene names
ORF Names:C3L
OrganismVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifier10254 [NCBI]
Taxonomic lineageViruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Vaccinia virus
Virus hostBos taurus (Bovine) [TaxID: 9913]

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serves to protect the virus against complement attack by inhibiting both classical and alternative pathways of complement activation. Binds C3b and C4b. Ref.3

Sequence similarities

Belongs to the receptors of complement activation (RCA) family.

Contains 4 Sushi (CCP/SCR) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.1
Chain20 – 263244Complement control protein
PRO_0000006024

Regions

Domain20 – 8364Sushi 1
Domain84 – 14562Sushi 2
Domain146 – 20358Sushi 3
Domain204 – 26360Sushi 4

Amino acid modifications

Disulfide bond21 ↔ 70 Potential
Disulfide bond54 ↔ 81 Potential
Disulfide bond86 ↔ 126 Potential
Disulfide bond112 ↔ 143 Potential
Disulfide bond148 ↔ 190 By similarity
Disulfide bond176 ↔ 201 By similarity
Disulfide bond206 ↔ 248 By similarity
Disulfide bond234 ↔ 261 By similarity

Secondary structure

1 .................................. 263
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P68638 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: E4322CC9A6EF8997

FASTA26328,629
        10         20         30         40         50         60 
MKVESVTFLT LLGIGCVLSC CTIPSRPINM KFKNSVETDA NANYNIGDTI EYLCLPGYRK 

        70         80         90        100        110        120 
QKMGPIYAKC TGTGWTLFNQ CIKRRCPSPR DIDNGQLDIG GVDFGSSITY SCNSGYHLIG 

       130        140        150        160        170        180 
ESKSYCELGS TGSMVWNPEA PICESVKCQS PPSISNGRHN GYEDFYTDGS VVTYSCNSGY 

       190        200        210        220        230        240 
SLIGNSGVLC SGGEWSDPPT CQIVKCPHPT ISNGYLSSGF KRSYSYNDNV DFKCKYGYKL 

       250        260 
SGSSSSTCSP GNTWKPELPK CVR

« Hide

References

[1]"Vaccinia virus encodes a secretory polypeptide structurally related to complement control proteins."
Kotwal G.J., Moss B.
Nature 335:176-178(1988) [PubMed: 3412473] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 20-37.
[2]"Analysis of a large cluster of nonessential genes deleted from a vaccinia virus terminal transposition mutant."
Kotwal G.J., Moss B.
Virology 167:524-537(1988) [PubMed: 2849238] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Vaccinia virus complement-control protein prevents antibody-dependent complement-enhanced neutralization of infectivity and contributes to virulence."
Isaacs S.N., Kotwal G.J., Moss B.
Proc. Natl. Acad. Sci. U.S.A. 89:628-632(1992) [PubMed: 1731333] [Abstract]
Cited for: FUNCTION.
[4]"NMR studies of a viral protein that mimics the regulators of complement activation."
Wiles A.P., Shaw G., Bright J., Perczel A., Campbell I.D., Barlow P.N.
J. Mol. Biol. 272:253-265(1997) [PubMed: 9299352] [Abstract]
Cited for: STRUCTURE BY NMR OF 146-263, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X13166 Genomic DNA. Translation: CAA31564.1.
M22812 Genomic DNA. Translation: AAA69605.1.
PIRWMVZSP. A31005.
RefSeqYP_232907.1. NC_006998.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1G40X-ray2.20A/B20-263[»]
1G44X-ray2.60A/B/C20-263[»]
1RIDX-ray2.10A/B20-263[»]
1VVCNMR-A146-263[»]
1VVDNMR-A146-263[»]
1VVENMR-A146-263[»]
1Y8EX-ray2.20A/B20-263[»]
ProteinModelPortalP68638.
SMRP68638. Positions 20-263.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-6740569.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3707640.

Phylogenomic databases

ProtClustDBPHA2927.

Family and domain databases

InterProIPR011176. CIP_VAC_C3L.
IPR016060. Complement_control_module.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
Gene3DG3DSA:2.10.70.10. Complement_control_module. 4 hits.
PfamPF00084. Sushi. 4 hits.
[Graphical view]
PIRSFPIRSF002486. CIP_VAC_C3L. 1 hit.
SMARTSM00032. CCP. 4 hits.
[Graphical view]
SUPFAMSSF57535. Complement_control_module. 4 hits.
PROSITEPS50923. SUSHI. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

DrugBankDB04786. Suramin.

Entry information

Entry nameVCP_VACCW
AccessionPrimary (citable) accession number: P68638
Secondary accession number(s): P10998
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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