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P68635

- DUT_VACCP

UniProt

P68635 - DUT_VACCP

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Vaccinia virus (strain L-IVP) (VACV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium.By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:DUT
ORF Names:F16
OrganismiVaccinia virus (strain L-IVP) (VACV)
Taxonomic identifieri31531 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182941Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP68635.
SMRiP68635. Positions 7-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

P68635-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFNMNINSPV RFVKETNRAK SPTRQSPGAA GYDLYSAYDY TIPPGERQLI
60 70 80 90 100
KTDISMSMPK ICYGRIAPRS GLSLKGIDIG GGVIDEDYRG NIGVILINNG
110 120 130 140
KCTFNVNTGD RIAQLIYQRI YYPELEEVQS LDSTNRGDQG FGSTGLR
Length:147
Mass (Da):16,264
Last modified:December 7, 2004 - v1
Checksum:iDA961240BF85FA2A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57977 Genomic DNA. Translation: AAA48296.1.
PIRiG42506. PRVZ7F.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57977 Genomic DNA. Translation: AAA48296.1 .
PIRi G42506. PRVZ7F.

3D structure databases

ProteinModelPortali P68635.
SMRi P68635. Positions 7-131.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Structural-functional organization of segment of vaccinia virus genome."
    Mikryukov N.N., Chizhikov V.E., Prikhod'Ko G.G., Urmmanov I.M., Serpinskii O.I., Blinov V.M., Nikulin A.E., Vasilenko S.K.
    Biotekhnologiya 4:442-449(1988)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDUT_VACCP
AccessioniPrimary (citable) accession number: P68635
Secondary accession number(s): P21035
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: October 1, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be a protease-like protein (pseudoprotease).Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3