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Protein

Protein A33

Gene

VACWR156

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Coordinates the incorporation of A36 into wrapped enveloped virion (EV) membranes and, subsequently, the production of actin tails. Therefore plays an essential role in efficient cell-to-cell spread of viral particles.3 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Protein A33
Gene namesi
Ordered Locus Names:VACWR156
ORF Names:A33R
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33IntravirionBy similarityAdd BLAST33
Transmembranei34 – 56HelicalSequence analysisAdd BLAST23
Topological domaini57 – 185Virion surfaceBy similarityAdd BLAST129

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000993171 – 185Protein A33Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62Interchain
Glycosylationi125N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer, disulfide-linked. Interacts with protein B5. Interacts (via C-terminus) with protein A36.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiP68617. 4 interactors.
MINTiMINT-6740399.

Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi101 – 105Combined sources5
Beta strandi108 – 117Combined sources10
Helixi119 – 128Combined sources10
Helixi136 – 139Combined sources4
Helixi145 – 148Combined sources4
Beta strandi156 – 159Combined sources4
Beta strandi176 – 183Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3K7BX-ray2.10A/B90-185[»]
SMRiP68617.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP68617.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 185C-type lectin-like domainAdd BLAST88

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG09000150.

Family and domain databases

InterProiView protein in InterPro
IPR009238. Chordopox_A33R.
PfamiView protein in Pfam
PF05966. Chordopox_A33R. 1 hit.

Sequencei

Sequence statusi: Complete.

P68617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTPENDEEQ TSVFSATVYG DKIQGKNKRK RVIGLCIRIS MVISLLSMIT
60 70 80 90 100
MSAFLIVRLN QCMSANEAAI TDAAVAVAAA SSTHRKVASS TTQYDHKESC
110 120 130 140 150
NGLYYQGSCY ILHSDYQLFS DAKANCTAES STLPNKSDVL ITWLIDYVED
160 170 180
TWGSDGNPIT KTTSDYQDSD VSQEVRKYFC VKTMN
Length:185
Mass (Da):20,506
Last modified:December 7, 2004 - v1
Checksum:i201CF65C2D2076A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11079 Genomic DNA. Translation: BAA01805.1.
M61187 Genomic DNA. Translation: AAA48330.1.
X57318 Genomic DNA. Translation: CAA40583.1.
AY243312 Genomic DNA. Translation: AAO89435.1.
PIRiH42520.
RefSeqiYP_233038.1. NC_006998.1.

Genome annotation databases

GeneIDi3707686.
KEGGivg:3707686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11079 Genomic DNA. Translation: BAA01805.1.
M61187 Genomic DNA. Translation: AAA48330.1.
X57318 Genomic DNA. Translation: CAA40583.1.
AY243312 Genomic DNA. Translation: AAO89435.1.
PIRiH42520.
RefSeqiYP_233038.1. NC_006998.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3K7BX-ray2.10A/B90-185[»]
SMRiP68617.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP68617. 4 interactors.
MINTiMINT-6740399.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3707686.
KEGGivg:3707686.

Phylogenomic databases

OrthoDBiVOG09000150.

Miscellaneous databases

EvolutionaryTraceiP68617.

Family and domain databases

InterProiView protein in InterPro
IPR009238. Chordopox_A33R.
PfamiView protein in Pfam
PF05966. Chordopox_A33R. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA33_VACCW
AccessioniPrimary (citable) accession number: P68617
Secondary accession number(s): P21056, Q76ZP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: May 10, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.