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P68616 (A33_VACCC) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein A33
Gene names
ORF Names:A33R
OrganismVaccinia virus (strain Copenhagen) (VACV) [Complete proteome]
Taxonomic identifier10249 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Coordinates the incorporation of A36 into intracellular envelopped virion (IEV) membranes and, subsequently, the production of actin tails. Therefore plays an essential role in efficient cell-to-cell spread of viral particles By similarity.

Subunit structure

Homodimer; disulfide-linked. Interacts with B5. Interacts (via C-terminus) with protein A36 By similarity.

Subcellular location

Host membrane; Single-pass type II membrane protein Potential. Note: Present in the enveloped virion (EV) membrane By similarity.

Sequence similarities

Belongs to the chordopoxvirinae A33 protein family.

Ontologies

Keywords
   Cellular componentHost membrane
Membrane
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componenthost cell membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionbinding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185Protein A33
PRO_0000099316

Regions

Topological domain1 – 3333Cytoplasmic By similarity
Transmembrane34 – 5623Helical; Potential
Topological domain57 – 185129Lumenal By similarity
Region98 – 18588C-type lectin-like domain

Amino acid modifications

Glycosylation1251N-linked (GlcNAc...); by host Potential
Glycosylation1351N-linked (GlcNAc...); by host Potential
Disulfide bond62Interchain

Sequences

Sequence LengthMass (Da)Tools
P68616 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 201CF65C2D2076A4

FASTA18520,506
        10         20         30         40         50         60 
MMTPENDEEQ TSVFSATVYG DKIQGKNKRK RVIGLCIRIS MVISLLSMIT MSAFLIVRLN 

        70         80         90        100        110        120 
QCMSANEAAI TDAAVAVAAA SSTHRKVASS TTQYDHKESC NGLYYQGSCY ILHSDYQLFS 

       130        140        150        160        170        180 
DAKANCTAES STLPNKSDVL ITWLIDYVED TWGSDGNPIT KTTSDYQDSD VSQEVRKYFC 


VKTMN 

« Hide

References

[1]"The complete DNA sequence of vaccinia virus."
Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E.
Virology 179:247-266(1990) [PubMed: 2219722] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Appendix to 'The complete DNA sequence of vaccinia virus'."
Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E.
Virology 179:517-563(1990)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M35027 Genomic DNA. Translation: AAA48160.1.
PIRH42520.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR016186. C-type_lectin-like.
IPR009238. Chordopox_A33R.
[Graphical view]
Gene3DG3DSA:3.10.100.10. C-type_lectin-like. 1 hit.
PfamPF05966. Chordopox_A33R. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA33_VACCC
AccessionPrimary (citable) accession number: P68616
Secondary accession number(s): P21056
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: October 19, 2011
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families