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Protein

Protein I2

Gene

I2L

Organism
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Late protein which probably plays a role in virus entry into the host cell.By similarity

GO - Biological processi

Keywordsi

Biological processViral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Protein I2
Gene namesi
ORF Names:I2L
OrganismiVariola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Taxonomic identifieri587200 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000119805 Componenti: Genome
  • UP000002060 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000995691 – 73Protein I2Add BLAST73

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.

Keywords - Developmental stagei

Late protein

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 64Poly-Leu6

Sequence similaritiesi

Belongs to the chordopoxvirinae I2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090001VW.

Family and domain databases

InterProiView protein in InterPro
IPR009175. Poxvirus_I2.
PfamiView protein in Pfam
PF12575. Pox_EPC_I2-L1. 1 hit.
PIRSFiPIRSF003766. VAC_I2L. 1 hit.

Sequencei

Sequence statusi: Complete.

P68607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLYAAIFG VFMGSPEDDL TDFIEIVKSV LSDEKTVTST NNTGCWGWYW
60 70
LIIIFFIVLI LLLLIYLYLK VVW
Length:73
Mass (Da):8,499
Last modified:December 7, 2004 - v1
Checksum:i9AA89F7883384C72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67119 Genomic DNA. Translation: CAA47556.1.
X69198 Genomic DNA. Translation: CAA48997.1.
L22579 Genomic DNA. Translation: AAA60804.1.
X76263 Genomic DNA. Translation: CAA53830.1.
PIRiF72157.
I36842.
T28494.
RefSeqiNP_042100.1. NC_001611.1.

Genome annotation databases

GeneIDi1486457.
KEGGivg:1486457.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiI2_VAR67
AccessioniPrimary (citable) accession number: P68607
Secondary accession number(s): P12922
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: March 15, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families