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Protein

Protein I2

Gene

VACWR071

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Late protein which probably plays a role in virus entry into the host cell.1 Publication

GO - Biological processi

Keywordsi

Biological processViral penetration into host cytoplasm, Virus entry into host cell

Protein family/group databases

TCDBi1.G.11.1.1. poxvirus cell entry protein complex (pep-c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein I2
Gene namesi
Ordered Locus Names:VACWR071
ORF Names:I2L
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000995681 – 73Protein I2Add BLAST73

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.1 Publication

Keywords - Developmental stagei

Late protein

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 64Poly-Leu6

Sequence similaritiesi

Belongs to the chordopoxvirinae I2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090001VW.

Family and domain databases

InterProiView protein in InterPro
IPR009175. Poxvirus_I2.
PfamiView protein in Pfam
PF12575. Pox_EPC_I2-L1. 1 hit.
PIRSFiPIRSF003766. VAC_I2L. 1 hit.

Sequencei

Sequence statusi: Complete.

P68606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLYAAIFG VFMGSPEDDL TDFIEIVKSV LSDEKTVTST NNTGCWGWYW
60 70
LIIIFFIVLI LLLLIYLYLK VVW
Length:73
Mass (Da):8,499
Last modified:December 7, 2004 - v1
Checksum:i9AA89F7883384C72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243312 Genomic DNA. Translation: AAO89350.1.
J03399 Genomic DNA. Translation: AAB59804.1.
PIRiB29889. WZVZI2.
RefSeqiYP_232953.1. NC_006998.1.

Genome annotation databases

GeneIDi3707604.
KEGGivg:3707604.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiI2_VACCW
AccessioniPrimary (citable) accession number: P68606
Secondary accession number(s): P12922, Q76ZV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: March 15, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families