P68598 (C7L_VACCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon antagonist C7L

Alternative name(s):
Host range protein 2

Gene names

Ordered Locus Names:	MVA018L, ACAM3000_MVA_018
ORF Names:	C7L

Organism

Vaccinia virus (strain Ankara) (VACV)

Taxonomic identifier

126794 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Vaccinia virus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	150 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Inhibits antiviral activity induced by type I interferons. Do not block signal transdution of IFN, but is important to counter the host antiviral state induced by a pre-treatment with IFN By similarity.
Sequence similarities	Belongs to the poxviruses C7 family.

Ontologies

Keywords
Biological process	Host-virus interaction Inhibition of host innate immune response by virus Viral immunoevasion
Developmental stage	Early protein
Gene Ontology (GO)
Biological process	evasion by virus of host immune response Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 150	150	Interferon antagonist C7L		PRO_0000099386

Sequences

	Sequence		Length	Mass (Da)
	P68598 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 47CDF841D563C0A4	FASTA	150	17,999
	10 20 30 40 50 60 MGIQHEFDII INGDIALRNL QLHKGDNYGC KLKIISNDYK KLKFRFIIRP DWSEIDEVKG 70 80 90 100 110 120 LTVFANNYAV KVNKVDDTFY YVIYEAVIHL YNKKTEILIY SDDENELFKH YYPYISLNMI 130 140 150 SKKYKVKEEN YSSPYIEHPL IPYRDYESMD

References

[1]	"The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses." Antoine G., Scheiflinger F., Dorner F., Falkner F.G. Virology 244:365-396(1998) [PubMed: 9601507] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J., Khristova M., Wohlhueter R.M. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate Acambis 3000.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U94848 Genomic DNA. Translation: AAB96405.1. AY603355 Genomic DNA. Translation: AAT10416.1.
PIR	WZVZB1. A33348.
RefSeq	YP_232903.1. NC_006998.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3707636.
Phylogenomic databases
ProtClustDB	PHA2919.
Family and domain databases
InterPro	IPR004967. Poxvirus_C7/F8A. [Graphical view]
Pfam	PF03287. Pox_C7_F8A. 1 hit. [Graphical view]
PIRSF	PIRSF003779. VAC_C7L. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C7L_VACCA

Accession

Primary (citable) accession number: P68598
Secondary accession number(s): P17363, Q76ZY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	December 7, 2004
Last modified:	December 14, 2011
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program