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P68586

- MTBP_BPPHT

UniProt

P68586 - MTBP_BPPHT

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Protein

Modification methylase Phi3TI

Gene
mtbP
Organism
Bacillus phage phi3T (Bacteriophage phi-3T)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme methylates the first cytosine within the sequences GGCC and GCNGC.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781 By similarity

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi2633. M.Phi3TI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase Phi3TI (EC:2.1.1.37)
Short name:
M.Phi3TI
Alternative name(s):
Cytosine-specific methyltransferase Phi3TI
Gene namesi
Name:mtbP
OrganismiBacillus phage phi3T (Bacteriophage phi-3T)
Taxonomic identifieri10736 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdalikevirusunclassified Lambda-like viruses
Virus hostiBacillus subtilis [TaxID: 1423]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Modification methylase Phi3TIPRO_0000087866Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP68586.
SMRiP68586. Positions 1-441.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 440437SAM-dependent MTase C5-typeAdd
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 2 hits.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 4 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P68586-1 [UniParc]FASTAAdd to Basket

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MSKLRVMSLF SGIGAFEAAL RNIGVDYELI GFSEIDKYAI KSYCAIHNVS    50
ETLNVGDISK AKKDNIPYFD LLTSGFPCPT FSVAGGRDGM EYKCSNCSHE 100
HLITYEDYKK GVKCPKCEAV SKAKDERGTL FFETALLAEE KKPKFVILEN 150
VKGLINSGNG QVLRIISETM NNIGYRIDLE LLNSKFFNVP QNRERVYIIG 200
IREDLVENEQ WVVGQKRNDV LSKGKKRLQE INIKSFNFKW PLQDTVTKRL 250
REILEDFVDE KYYLNEEKTK KLVEQLGTAP LQKQEVREPL MVGHVDLKGH 300
DAIKRVYSPE GLSPTLTTMG GGHREPKIAE KQKEVRAVLT PEREEKRQNG 350
RRFKENGEPA FTVNTIDRHG VAIGEYPKYK IRKLSPLECW RLQAFDDEDF 400
EKAFAAGISN SQLYKQAGNS ITVSVLESIF QELIHTYVNK ESE 443
Length:443
Mass (Da):50,510
Last modified:December 7, 2004 - v1
Checksum:i2BF02005159E9879
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401I → V1 Publication
Sequence conflicti196 – 1961V → L1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13488 Genomic DNA. Translation: AAA32352.1.
PIRiA24465. CTBPPT.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13488 Genomic DNA. Translation: AAA32352.1 .
PIRi A24465. CTBPPT.

3D structure databases

ProteinModelPortali P68586.
SMRi P68586. Positions 1-441.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 2633. M.Phi3TI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 2 hits.
InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 2 hits.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 4 hits.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA methyltransferase genes of Bacillus subtilis phages: comparison of their nucleotide sequences."
    Tran-Betcke A., Behrens B., Noyer-Weidner M., Trautner T.A.
    Gene 42:89-96(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequential order of target-recognizing domains in multispecific DNA-methyltransferases."
    Wilke K., Rauhut E., Noyer-Weidner M., Lauster R., Pawlek B., Behrens B., Trautner T.A.
    EMBO J. 7:2601-2609(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-91 AND 125-443.

Entry informationi

Entry nameiMTBP_BPPHT
AccessioniPrimary (citable) accession number: P68586
Secondary accession number(s): P05795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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