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Protein

SPBc2 prophage-derived sublancin-168-processing and transport ATP-binding protein SunT

Gene

sunT

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

SunT (TC 3.A.1.112.4) is required for production of the lantibiotic sublancin-168, probably by both processing the signal peptide and exporting the resulting mature lantibiotic.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei18PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi516 – 523ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Antibiotic biosynthesis, Bacteriocin transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU21470-MONOMER.

Protein family/group databases

MEROPSiC39.A03.
TCDBi3.A.1.112.4. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
SPBc2 prophage-derived sublancin-168-processing and transport ATP-binding protein SunT (EC:3.4.22.-)
Gene namesi
Name:sunT
Synonyms:yolH
Ordered Locus Names:BSU21470
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei167 – 187HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei205 – 225HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei281 – 301HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei306 – 326HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei388 – 408HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei418 – 438HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000929811 – 705SPBc2 prophage-derived sublancin-168-processing and transport ATP-binding protein SunTAdd BLAST705

Proteomic databases

PaxDbiP68579.
PRIDEiP68579.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100011821.

Structurei

3D structure databases

ProteinModelPortaliP68579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 138Peptidase C39PROSITE-ProRule annotationAdd BLAST127
Domaini168 – 450ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST283
Domaini483 – 705ABC transporterPROSITE-ProRule annotationAdd BLAST223

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation
Contains 1 peptidase C39 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2274. LUCA.
HOGENOMiHOG000136512.
InParanoidiP68579.
KOiK06148.
OMAiNINIDRR.
PhylomeDBiP68579.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
IPR005074. Peptidase_C39.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF03412. Peptidase_C39. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS50990. PEPTIDASE_C39. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P68579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKKKYVHT KQFNSHDCGL ACISSILKFH NLNYGIDFLL DLIGDKEGYS
60 70 80 90 100
LRDLIVIFKK MGIKTRPLEL QENKTFEALK QIKLPCIALL EGEEYGHYIT
110 120 130 140 150
IYEIRNNYLL VSDPDKDKIT KIKKEDFESK FTNFILEIDK ESIPEKEKDQ
160 170 180 190 200
KKHSYFFKDI LFRNKLIVFV ILLTSLFVVG LAVAGSFYIK FLVDLIIPRS
210 220 230 240 250
LRESLITITL IFISMVLIRC IFDFVRSYLI IKLSYKVDKE MSNVYFNKVT
260 270 280 290 300
KLPINFFENR EDGEVISRFN DGIYIKDFFS ANFVTAIIDI ILILGLGVIL
310 320 330 340 350
YRTNNILFLT IILPILLLSC LAILFFDHLK KKNQKLMEDK AKSTSLLINF
360 370 380 390 400
LKNMTTVYSL NKTSFFLEKF HLTYDKQLNS TFSVAKAVIS NEILKGLIQN
410 420 430 440 450
SFTIIILWVG TRQVLNDSMS LGTLLFINTL AAFLLSSLDR ILSMQSDLQQ
460 470 480 490 500
AHVASIRFFD VVNYPVQQDS NENLTELDFI QNIKTVNLNI GADPMRYIVE
510 520 530 540 550
DINLILDRKD KVLIIGESGT GKSTFAKSLS KLYKVPDKSI YLNGLDINRY
560 570 580 590 600
DHLSIRKRIV YIDENPFLFK GTIKENLCMG EIFDQNEIEN ACIMSQCHEF
610 620 630 640 650
ICNLDKQYSY KLSENGSNLS TGQKQRLALA RAILHQPQVL ILDESLSNID
660 670 680 690 700
PDNTKLIYET LHRMDCLIIL ITHNDPSNFK YNKKLVFRNN RIIESSYSEN

KEYSI
Length:705
Mass (Da):81,564
Last modified:December 7, 2004 - v1
Checksum:i0F94D9964AF8BD3A
GO

Sequence cautioni

The sequence AAC63532 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014938 Genomic DNA. Translation: AAC63532.1. Different initiation.
AL009126 Genomic DNA. Translation: CAB14065.1.
RefSeqiNP_390030.1. NC_000964.3.
WP_003246186.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14065; CAB14065; BSU21470.
GeneIDi939124.
KEGGibsu:BSU21470.
PATRICi18976099. VBIBacSub10457_2240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014938 Genomic DNA. Translation: AAC63532.1. Different initiation.
AL009126 Genomic DNA. Translation: CAB14065.1.
RefSeqiNP_390030.1. NC_000964.3.
WP_003246186.1. NZ_JNCM01000036.1.

3D structure databases

ProteinModelPortaliP68579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100011821.

Protein family/group databases

MEROPSiC39.A03.
TCDBi3.A.1.112.4. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP68579.
PRIDEiP68579.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14065; CAB14065; BSU21470.
GeneIDi939124.
KEGGibsu:BSU21470.
PATRICi18976099. VBIBacSub10457_2240.

Phylogenomic databases

eggNOGiCOG2274. LUCA.
HOGENOMiHOG000136512.
InParanoidiP68579.
KOiK06148.
OMAiNINIDRR.
PhylomeDBiP68579.

Enzyme and pathway databases

BioCyciBSUB:BSU21470-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
IPR005074. Peptidase_C39.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF03412. Peptidase_C39. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS50990. PEPTIDASE_C39. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUNT_BACSU
AccessioniPrimary (citable) accession number: P68579
Secondary accession number(s): O30671, O31988, O64034
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: October 5, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.