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Protein

UBX domain-containing protein 2A

Gene

UBXN2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 2A
Alternative name(s):
UBX domain-containing protein 4
Gene namesi
Name:UBXN2A
Synonyms:UBXD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:27265. UBXN2A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408375.

Polymorphism and mutation databases

BioMutaiUBXN2A.
DMDMi55976658.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259UBX domain-containing protein 2APRO_0000211031Add
BLAST

Proteomic databases

EPDiP68543.
MaxQBiP68543.
PaxDbiP68543.
PeptideAtlasiP68543.
PRIDEiP68543.

PTM databases

iPTMnetiP68543.
PhosphoSiteiP68543.

Expressioni

Gene expression databases

BgeeiP68543.
CleanExiHS_UBXN2A.
GenevisibleiP68543. HS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127913. 20 interactions.
IntActiP68543. 12 interactions.
MINTiMINT-8247623.
STRINGi9606.ENSP00000312107.

Structurei

3D structure databases

ProteinModelPortaliP68543.
SMRiP68543. Positions 59-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 12465SEPPROSITE-ProRule annotationAdd
BLAST
Domaini169 – 24678UBXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SEP domain.PROSITE-ProRule annotation
Contains 1 UBX domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2086. Eukaryota.
ENOG410YGXU. LUCA.
GeneTreeiENSGT00520000055567.
HOGENOMiHOG000088627.
HOVERGENiHBG106575.
InParanoidiP68543.
OMAiITNIQIW.
OrthoDBiEOG7ZKSBB.
PhylomeDBiP68543.
TreeFamiTF312973.

Family and domain databases

InterProiIPR012989. SEP_domain.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF08059. SEP. 1 hit.
PF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00553. SEP. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF102848. SSF102848. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51399. SEP. 1 hit.
PS50033. UBX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P68543-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDVDNLKSI KEEWVCETGS DNQPLGNNQQ SNCEYFVDSL FEEAQKVSSK
60 70 80 90 100
CVSPAEQKKQ VDVNIKLWKN GFTVNDDFRS YSDGASQQFL NSIKKGELPS
110 120 130 140 150
ELQGIFDKEE VDVKVEDKKN EICLSTKPVF QPFSGQGHRL GSATPKIVSK
160 170 180 190 200
AKNIEVENKN NLSAVPLNNL EPITNIQIWL ANGKRIVQKF NITHRVSHIK
210 220 230 240 250
DFIEKYQGSQ RSPPFSLATA LPVLRLLDET LTLEEADLQN AVIIQRLQKT

ASFRELSEH
Length:259
Mass (Da):29,278
Last modified:November 23, 2004 - v1
Checksum:i4B2CD68375A0BABD
GO
Isoform 2 (identifier: P68543-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-194: Missing.

Note: No experimental confirmation available.
Show »
Length:206
Mass (Da):23,373
Checksum:i21A49C25EEFF98C3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei142 – 19453Missing in isoform 2. 1 PublicationVSP_056306Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291192 mRNA. Translation: BAF83881.1.
AL832079 mRNA. No translation available.
AC066692 Genomic DNA. No translation available.
BC092484 mRNA. Translation: AAH92484.1.
BC093681 mRNA. Translation: AAH93681.1.
BC111997 mRNA. Translation: AAI11998.1.
BC143298 mRNA. Translation: AAI43299.1.
CCDSiCCDS1704.1. [P68543-1]
RefSeqiNP_859064.2. NM_181713.3. [P68543-1]
XP_005264223.1. XM_005264166.3. [P68543-1]
XP_005264224.1. XM_005264167.3. [P68543-1]
XP_005264225.1. XM_005264168.3. [P68543-1]
XP_005264226.1. XM_005264169.3. [P68543-1]
XP_011530934.1. XM_011532632.1. [P68543-1]
XP_011530935.1. XM_011532633.1. [P68543-1]
UniGeneiHs.591576.

Genome annotation databases

EnsembliENST00000309033; ENSP00000312107; ENSG00000173960. [P68543-1]
ENST00000404924; ENSP00000385525; ENSG00000173960. [P68543-1]
ENST00000535786; ENSP00000440533; ENSG00000173960. [P68543-2]
GeneIDi165324.
KEGGihsa:165324.
UCSCiuc002ren.4. human. [P68543-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291192 mRNA. Translation: BAF83881.1.
AL832079 mRNA. No translation available.
AC066692 Genomic DNA. No translation available.
BC092484 mRNA. Translation: AAH92484.1.
BC093681 mRNA. Translation: AAH93681.1.
BC111997 mRNA. Translation: AAI11998.1.
BC143298 mRNA. Translation: AAI43299.1.
CCDSiCCDS1704.1. [P68543-1]
RefSeqiNP_859064.2. NM_181713.3. [P68543-1]
XP_005264223.1. XM_005264166.3. [P68543-1]
XP_005264224.1. XM_005264167.3. [P68543-1]
XP_005264225.1. XM_005264168.3. [P68543-1]
XP_005264226.1. XM_005264169.3. [P68543-1]
XP_011530934.1. XM_011532632.1. [P68543-1]
XP_011530935.1. XM_011532633.1. [P68543-1]
UniGeneiHs.591576.

3D structure databases

ProteinModelPortaliP68543.
SMRiP68543. Positions 59-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127913. 20 interactions.
IntActiP68543. 12 interactions.
MINTiMINT-8247623.
STRINGi9606.ENSP00000312107.

PTM databases

iPTMnetiP68543.
PhosphoSiteiP68543.

Polymorphism and mutation databases

BioMutaiUBXN2A.
DMDMi55976658.

Proteomic databases

EPDiP68543.
MaxQBiP68543.
PaxDbiP68543.
PeptideAtlasiP68543.
PRIDEiP68543.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309033; ENSP00000312107; ENSG00000173960. [P68543-1]
ENST00000404924; ENSP00000385525; ENSG00000173960. [P68543-1]
ENST00000535786; ENSP00000440533; ENSG00000173960. [P68543-2]
GeneIDi165324.
KEGGihsa:165324.
UCSCiuc002ren.4. human. [P68543-1]

Organism-specific databases

CTDi165324.
GeneCardsiUBXN2A.
HGNCiHGNC:27265. UBXN2A.
neXtProtiNX_P68543.
PharmGKBiPA162408375.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2086. Eukaryota.
ENOG410YGXU. LUCA.
GeneTreeiENSGT00520000055567.
HOGENOMiHOG000088627.
HOVERGENiHBG106575.
InParanoidiP68543.
OMAiITNIQIW.
OrthoDBiEOG7ZKSBB.
PhylomeDBiP68543.
TreeFamiTF312973.

Miscellaneous databases

ChiTaRSiUBXN2A. human.
GenomeRNAii165324.
PROiP68543.

Gene expression databases

BgeeiP68543.
CleanExiHS_UBXN2A.
GenevisibleiP68543. HS.

Family and domain databases

InterProiIPR012989. SEP_domain.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF08059. SEP. 1 hit.
PF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00553. SEP. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF102848. SSF102848. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51399. SEP. 1 hit.
PS50033. UBX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Adipose tissue.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Liver and Placenta.

Entry informationi

Entry nameiUBX2A_HUMAN
AccessioniPrimary (citable) accession number: P68543
Secondary accession number(s): A8K577, B7ZKP8, Q569G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.