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Protein

UBX domain-containing protein 2A

Gene

UBXN2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 2A
Alternative name(s):
UBX domain-containing protein 4
Gene namesi
Name:UBXN2A
Synonyms:UBXD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000173960.12
HGNCiHGNC:27265 UBXN2A
neXtProtiNX_P68543

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi165324
OpenTargetsiENSG00000173960
PharmGKBiPA162408375

Polymorphism and mutation databases

BioMutaiUBXN2A
DMDMi55976658

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002110311 – 259UBX domain-containing protein 2AAdd BLAST259

Proteomic databases

EPDiP68543
MaxQBiP68543
PaxDbiP68543
PeptideAtlasiP68543
PRIDEiP68543

PTM databases

iPTMnetiP68543
PhosphoSitePlusiP68543

Expressioni

Gene expression databases

BgeeiENSG00000173960
CleanExiHS_UBXN2A
GenevisibleiP68543 HS

Organism-specific databases

HPAiHPA065482
HPA069096

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
VCPP550723EBI-1993668,EBI-355164

GO - Molecular functioni

Protein-protein interaction databases

BioGridi12791321 interactors.
IntActiP68543 13 interactors.
MINTiP68543
STRINGi9606.ENSP00000312107

Structurei

3D structure databases

ProteinModelPortaliP68543
SMRiP68543
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 124SEPPROSITE-ProRule annotationAdd BLAST65
Domaini169 – 246UBXPROSITE-ProRule annotationAdd BLAST78

Phylogenomic databases

eggNOGiKOG2086 Eukaryota
ENOG410YGXU LUCA
GeneTreeiENSGT00520000055567
HOGENOMiHOG000088627
HOVERGENiHBG106575
InParanoidiP68543
OMAiITNIQIW
OrthoDBiEOG091G0QFZ
PhylomeDBiP68543
TreeFamiTF312973

Family and domain databases

Gene3Di3.30.420.2101 hit
InterProiView protein in InterPro
IPR036241 NSFL1C_SEP_dom_sf
IPR012989 SEP_domain
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF08059 SEP, 1 hit
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00553 SEP, 1 hit
SM00166 UBX, 1 hit
SUPFAMiSSF102848 SSF102848, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51399 SEP, 1 hit
PS50033 UBX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P68543-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDVDNLKSI KEEWVCETGS DNQPLGNNQQ SNCEYFVDSL FEEAQKVSSK
60 70 80 90 100
CVSPAEQKKQ VDVNIKLWKN GFTVNDDFRS YSDGASQQFL NSIKKGELPS
110 120 130 140 150
ELQGIFDKEE VDVKVEDKKN EICLSTKPVF QPFSGQGHRL GSATPKIVSK
160 170 180 190 200
AKNIEVENKN NLSAVPLNNL EPITNIQIWL ANGKRIVQKF NITHRVSHIK
210 220 230 240 250
DFIEKYQGSQ RSPPFSLATA LPVLRLLDET LTLEEADLQN AVIIQRLQKT

ASFRELSEH
Length:259
Mass (Da):29,278
Last modified:November 23, 2004 - v1
Checksum:i4B2CD68375A0BABD
GO
Isoform 2 (identifier: P68543-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-194: Missing.

Note: No experimental confirmation available.
Show »
Length:206
Mass (Da):23,373
Checksum:i21A49C25EEFF98C3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056306142 – 194Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291192 mRNA Translation: BAF83881.1
AL832079 mRNA No translation available.
AC066692 Genomic DNA No translation available.
BC092484 mRNA Translation: AAH92484.1
BC093681 mRNA Translation: AAH93681.1
BC111997 mRNA Translation: AAI11998.1
BC143298 mRNA Translation: AAI43299.1
CCDSiCCDS1704.1 [P68543-1]
RefSeqiNP_859064.2, NM_181713.3 [P68543-1]
XP_005264223.1, XM_005264166.4 [P68543-1]
XP_005264224.1, XM_005264167.4 [P68543-1]
XP_005264225.1, XM_005264168.4 [P68543-1]
XP_005264226.1, XM_005264169.4 [P68543-1]
XP_011530935.1, XM_011532633.2 [P68543-1]
UniGeneiHs.591576

Genome annotation databases

EnsembliENST00000309033; ENSP00000312107; ENSG00000173960 [P68543-1]
ENST00000404924; ENSP00000385525; ENSG00000173960 [P68543-1]
GeneIDi165324
KEGGihsa:165324
UCSCiuc002ren.4 human [P68543-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUBX2A_HUMAN
AccessioniPrimary (citable) accession number: P68543
Secondary accession number(s): A8K577, B7ZKP8, Q569G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome