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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme A axial ligand)Curated
Metal bindingi243 – 2431Copper BCurated
Metal bindingi247 – 2471Copper BCurated
Metal bindingi292 – 2921Copper BCurated
Metal bindingi293 – 2931Copper BCurated
Metal bindingi378 – 3781Iron (heme A3 axial ligand)Curated
Metal bindingi380 – 3801Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Synonyms:COI, COXI
Encoded oniMitochondrion
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeTriticum
ProteomesiUP000019116 Componenti: Unplaced

Organism-specific databases

GrameneiP68539.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence AnalysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Transmembranei186 – 20621HelicalSequence AnalysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence AnalysisAdd
BLAST
Transmembranei340 – 36021HelicalSequence AnalysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence AnalysisAdd
BLAST
Transmembranei414 – 43421HelicalSequence AnalysisAdd
BLAST
Transmembranei447 – 46721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. plasma membrane Source: InterPro
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Cytochrome c oxidase subunit 1PRO_0000183429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP68539.
SMRiP68539. Positions 6-515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OMAiRLWQHIF.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P68539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNMVRWLFS TNHKDIGTLY FIFGAIAGVM GTCFSVLIRM ELARPGDQIL
60 70 80 90 100
GGNHQLYNVL ITAHAFLMIF FMVMPAMIGG FGNWFVPILI GAPDMAFPRL
110 120 130 140 150
NNISFWLLPP SLLLLLSSAL VEVGSGTGWT VYPPLSGITS HSGGAVDLAI
160 170 180 190 200
FSLHLSGISS ILGSINFITT IFNMRGPGMT MHRLPLFVWS VLVTAFLLLL
210 220 230 240 250
SLPVLAGAIT MLLTDRNFNT TFFDPAGGGD PILYQHLFWF FGHPEVYILI
260 270 280 290 300
LPGFGIISHI VSTFSRKPVF GYLGMVYAMI SIGVLGFLVW AHHMFTVGLD
310 320 330 340 350
VDTRAYFTAA TMIIAVPTGI KIFSWIATMW GGSIQYKTPM LFAVGFIFLF
360 370 380 390 400
TIGGLTGIVL ANSGLDIALH DTYYVVAHFH YVLSMGAVFA LFAGFYYWVG
410 420 430 440 450
KIFGRTYPET LGQIHFWITF FGVNLTFFPM HFLGLSGMPR RIPDYPDAYA
460 470 480 490 500
GWNALSSFGS YISVVGIRRF FVVVAITSSS GKNQKCAESP WAVEQNPTTL
510 520
EWLVQSPPAF HTFGELPAVK ETKS
Length:524
Mass (Da):57,757
Last modified:November 23, 2004 - v1
Checksum:iECD6E0AAB74F1DE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00417 Genomic DNA. Translation: CAA68474.1.
X56186 Genomic DNA. Translation: CAA39651.1.
PIRiS16256.
RefSeqiYP_398419.1. NC_007579.1.

Genome annotation databases

EnsemblPlantsiEPlTAET00000010152; EPlTAEP00000010117; EPlTAEG00000010152.
Traes_1BS_520702625.1; Traes_1BS_520702625.1; Traes_1BS_520702625.
Traes_1DS_520702625.1; Traes_1DS_520702625.1; Traes_1DS_520702625.
Traes_3AL_520702625.1; Traes_3AL_520702625.1; Traes_3AL_520702625.
Traes_4AL_520702625.1; Traes_4AL_520702625.1; Traes_4AL_520702625.
Traes_4AS_520702625.1; Traes_4AS_520702625.1; Traes_4AS_520702625.
Traes_5AS_520702625.1; Traes_5AS_520702625.1; Traes_5AS_520702625.
Traes_5BS_520702625.1; Traes_5BS_520702625.1; Traes_5BS_520702625.
Traes_5DL_520702625.1; Traes_5DL_520702625.1; Traes_5DL_520702625.
Traes_6BS_520702625.1; Traes_6BS_520702625.1; Traes_6BS_520702625.
GeneIDi3800084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00417 Genomic DNA. Translation: CAA68474.1.
X56186 Genomic DNA. Translation: CAA39651.1.
PIRiS16256.
RefSeqiYP_398419.1. NC_007579.1.

3D structure databases

ProteinModelPortaliP68539.
SMRiP68539. Positions 6-515.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiEPlTAET00000010152; EPlTAEP00000010117; EPlTAEG00000010152.
Traes_1BS_520702625.1; Traes_1BS_520702625.1; Traes_1BS_520702625.
Traes_1DS_520702625.1; Traes_1DS_520702625.1; Traes_1DS_520702625.
Traes_3AL_520702625.1; Traes_3AL_520702625.1; Traes_3AL_520702625.
Traes_4AL_520702625.1; Traes_4AL_520702625.1; Traes_4AL_520702625.
Traes_4AS_520702625.1; Traes_4AS_520702625.1; Traes_4AS_520702625.
Traes_5AS_520702625.1; Traes_5AS_520702625.1; Traes_5AS_520702625.
Traes_5BS_520702625.1; Traes_5BS_520702625.1; Traes_5BS_520702625.
Traes_5DL_520702625.1; Traes_5DL_520702625.1; Traes_5DL_520702625.
Traes_6BS_520702625.1; Traes_6BS_520702625.1; Traes_6BS_520702625.
GeneIDi3800084.

Organism-specific databases

GrameneiP68539.

Phylogenomic databases

OMAiRLWQHIF.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the wheat mitochondrial gene for subunit I of cytochrome oxidase."
    Bonen L., Boer P.H., McIntosh J.E., Gray M.W.
    Nucleic Acids Res. 15:6734-6734(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Thatcher.
  2. "A chimeric open reading frame in the 5' flanking region of coxI mitochondrial DNA from cytoplasmic male-sterile wheat."
    Rathburn H.B., Hedgcoth C.
    Plant Mol. Biol. 16:909-912(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_WHEAT
AccessioniPrimary (citable) accession number: P68539
Secondary accession number(s): P08741
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 23, 2004
Last modified: April 1, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.