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P68539 (COX1_WHEAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COX1
Synonyms:COI, COXI
Encoded onMitochondrion
OrganismTriticum aestivum (Wheat) [Complete proteome]
Taxonomic identifier4565 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeTriticum

Protein attributes

Sequence length524 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 524524Cytochrome c oxidase subunit 1
PRO_0000183429

Regions

Transmembrane18 – 3821Helical; Potential
Transmembrane66 – 8621Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane237 – 25721Helical; Potential
Transmembrane269 – 28921Helical; Potential
Transmembrane312 – 33221Helical; Potential
Transmembrane340 – 36021Helical; Potential
Transmembrane379 – 39921Helical; Potential
Transmembrane414 – 43421Helical; Potential
Transmembrane447 – 46721Helical; Potential

Sites

Metal binding641Iron (heme A axial ligand) Probable
Metal binding2431Copper B Probable
Metal binding2471Copper B Probable
Metal binding2921Copper B Probable
Metal binding2931Copper B Probable
Metal binding3781Iron (heme A3 axial ligand) Probable
Metal binding3801Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
P68539 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: ECD6E0AAB74F1DE1

FASTA52457,757
        10         20         30         40         50         60 
MTNMVRWLFS TNHKDIGTLY FIFGAIAGVM GTCFSVLIRM ELARPGDQIL GGNHQLYNVL 

        70         80         90        100        110        120 
ITAHAFLMIF FMVMPAMIGG FGNWFVPILI GAPDMAFPRL NNISFWLLPP SLLLLLSSAL 

       130        140        150        160        170        180 
VEVGSGTGWT VYPPLSGITS HSGGAVDLAI FSLHLSGISS ILGSINFITT IFNMRGPGMT 

       190        200        210        220        230        240 
MHRLPLFVWS VLVTAFLLLL SLPVLAGAIT MLLTDRNFNT TFFDPAGGGD PILYQHLFWF 

       250        260        270        280        290        300 
FGHPEVYILI LPGFGIISHI VSTFSRKPVF GYLGMVYAMI SIGVLGFLVW AHHMFTVGLD 

       310        320        330        340        350        360 
VDTRAYFTAA TMIIAVPTGI KIFSWIATMW GGSIQYKTPM LFAVGFIFLF TIGGLTGIVL 

       370        380        390        400        410        420 
ANSGLDIALH DTYYVVAHFH YVLSMGAVFA LFAGFYYWVG KIFGRTYPET LGQIHFWITF 

       430        440        450        460        470        480 
FGVNLTFFPM HFLGLSGMPR RIPDYPDAYA GWNALSSFGS YISVVGIRRF FVVVAITSSS 

       490        500        510        520 
GKNQKCAESP WAVEQNPTTL EWLVQSPPAF HTFGELPAVK ETKS 

« Hide

References

[1]"Nucleotide sequence of the wheat mitochondrial gene for subunit I of cytochrome oxidase."
Bonen L., Boer P.H., McIntosh J.E., Gray M.W.
Nucleic Acids Res. 15:6734-6734(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Thatcher.
[2]"A chimeric open reading frame in the 5' flanking region of coxI mitochondrial DNA from cytoplasmic male-sterile wheat."
Rathburn H.B., Hedgcoth C.
Plant Mol. Biol. 16:909-912(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y00417 Genomic DNA. Translation: CAA68474.1.
X56186 Genomic DNA. Translation: CAA39651.1.
PIRS16256.
RefSeqYP_398419.1. NC_007579.1.

3D structure databases

ProteinModelPortalP68539.
SMRP68539. Positions 6-515.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsTraes_1BS_520702625.1; Traes_1BS_520702625.1; Traes_1BS_520702625.
Traes_1DS_520702625.1; Traes_1DS_520702625.1; Traes_1DS_520702625.
Traes_3AL_520702625.1; Traes_3AL_520702625.1; Traes_3AL_520702625.
Traes_4AL_520702625.1; Traes_4AL_520702625.1; Traes_4AL_520702625.
Traes_4AS_520702625.1; Traes_4AS_520702625.1; Traes_4AS_520702625.
Traes_5AS_520702625.1; Traes_5AS_520702625.1; Traes_5AS_520702625.
Traes_5BS_520702625.1; Traes_5BS_520702625.1; Traes_5BS_520702625.
Traes_5DL_520702625.1; Traes_5DL_520702625.1; Traes_5DL_520702625.
Traes_6BS_520702625.1; Traes_6BS_520702625.1; Traes_6BS_520702625.
GeneID3800084.

Organism-specific databases

GrameneP68539.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
TIGRFAMsTIGR02891. CtaD_CoxA. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_WHEAT
AccessionPrimary (citable) accession number: P68539
Secondary accession number(s): P08741
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways