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P68539

- COX1_WHEAT

UniProt

P68539 - COX1_WHEAT

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Protein
Cytochrome c oxidase subunit 1
Gene
COX1, COI, COXI
Organism
Triticum aestivum (Wheat)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme A axial ligand) Inferred
Metal bindingi243 – 2431Copper B Inferred
Metal bindingi247 – 2471Copper B Inferred
Metal bindingi292 – 2921Copper B Inferred
Metal bindingi293 – 2931Copper B Inferred
Metal bindingi378 – 3781Iron (heme A3 axial ligand) Inferred
Metal bindingi380 – 3801Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Synonyms:COI, COXI
Encoded oniMitochondrion
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeTriticum
ProteomesiUP000019116: Unplaced

Organism-specific databases

GrameneiP68539.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821Helical; Reviewed prediction
Add
BLAST
Transmembranei66 – 8621Helical; Reviewed prediction
Add
BLAST
Transmembranei103 – 12321Helical; Reviewed prediction
Add
BLAST
Transmembranei148 – 16821Helical; Reviewed prediction
Add
BLAST
Transmembranei186 – 20621Helical; Reviewed prediction
Add
BLAST
Transmembranei237 – 25721Helical; Reviewed prediction
Add
BLAST
Transmembranei269 – 28921Helical; Reviewed prediction
Add
BLAST
Transmembranei312 – 33221Helical; Reviewed prediction
Add
BLAST
Transmembranei340 – 36021Helical; Reviewed prediction
Add
BLAST
Transmembranei379 – 39921Helical; Reviewed prediction
Add
BLAST
Transmembranei414 – 43421Helical; Reviewed prediction
Add
BLAST
Transmembranei447 – 46721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. plasma membrane Source: InterPro
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Cytochrome c oxidase subunit 1
PRO_0000183429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP68539.
SMRiP68539. Positions 6-515.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P68539-1 [UniParc]FASTAAdd to Basket

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MTNMVRWLFS TNHKDIGTLY FIFGAIAGVM GTCFSVLIRM ELARPGDQIL    50
GGNHQLYNVL ITAHAFLMIF FMVMPAMIGG FGNWFVPILI GAPDMAFPRL 100
NNISFWLLPP SLLLLLSSAL VEVGSGTGWT VYPPLSGITS HSGGAVDLAI 150
FSLHLSGISS ILGSINFITT IFNMRGPGMT MHRLPLFVWS VLVTAFLLLL 200
SLPVLAGAIT MLLTDRNFNT TFFDPAGGGD PILYQHLFWF FGHPEVYILI 250
LPGFGIISHI VSTFSRKPVF GYLGMVYAMI SIGVLGFLVW AHHMFTVGLD 300
VDTRAYFTAA TMIIAVPTGI KIFSWIATMW GGSIQYKTPM LFAVGFIFLF 350
TIGGLTGIVL ANSGLDIALH DTYYVVAHFH YVLSMGAVFA LFAGFYYWVG 400
KIFGRTYPET LGQIHFWITF FGVNLTFFPM HFLGLSGMPR RIPDYPDAYA 450
GWNALSSFGS YISVVGIRRF FVVVAITSSS GKNQKCAESP WAVEQNPTTL 500
EWLVQSPPAF HTFGELPAVK ETKS 524
Length:524
Mass (Da):57,757
Last modified:November 23, 2004 - v1
Checksum:iECD6E0AAB74F1DE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00417 Genomic DNA. Translation: CAA68474.1.
X56186 Genomic DNA. Translation: CAA39651.1.
PIRiS16256.
RefSeqiYP_398419.1. NC_007579.1.

Genome annotation databases

EnsemblPlantsiTraes_1BS_520702625.1; Traes_1BS_520702625.1; Traes_1BS_520702625.
Traes_1DS_520702625.1; Traes_1DS_520702625.1; Traes_1DS_520702625.
Traes_3AL_520702625.1; Traes_3AL_520702625.1; Traes_3AL_520702625.
Traes_4AL_520702625.1; Traes_4AL_520702625.1; Traes_4AL_520702625.
Traes_4AS_520702625.1; Traes_4AS_520702625.1; Traes_4AS_520702625.
Traes_5AS_520702625.1; Traes_5AS_520702625.1; Traes_5AS_520702625.
Traes_5BS_520702625.1; Traes_5BS_520702625.1; Traes_5BS_520702625.
Traes_5DL_520702625.1; Traes_5DL_520702625.1; Traes_5DL_520702625.
Traes_6BS_520702625.1; Traes_6BS_520702625.1; Traes_6BS_520702625.
GeneIDi3800084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00417 Genomic DNA. Translation: CAA68474.1 .
X56186 Genomic DNA. Translation: CAA39651.1 .
PIRi S16256.
RefSeqi YP_398419.1. NC_007579.1.

3D structure databases

ProteinModelPortali P68539.
SMRi P68539. Positions 6-515.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi Traes_1BS_520702625.1 ; Traes_1BS_520702625.1 ; Traes_1BS_520702625 .
Traes_1DS_520702625.1 ; Traes_1DS_520702625.1 ; Traes_1DS_520702625 .
Traes_3AL_520702625.1 ; Traes_3AL_520702625.1 ; Traes_3AL_520702625 .
Traes_4AL_520702625.1 ; Traes_4AL_520702625.1 ; Traes_4AL_520702625 .
Traes_4AS_520702625.1 ; Traes_4AS_520702625.1 ; Traes_4AS_520702625 .
Traes_5AS_520702625.1 ; Traes_5AS_520702625.1 ; Traes_5AS_520702625 .
Traes_5BS_520702625.1 ; Traes_5BS_520702625.1 ; Traes_5BS_520702625 .
Traes_5DL_520702625.1 ; Traes_5DL_520702625.1 ; Traes_5DL_520702625 .
Traes_6BS_520702625.1 ; Traes_6BS_520702625.1 ; Traes_6BS_520702625 .
GeneIDi 3800084.

Organism-specific databases

Gramenei P68539.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the wheat mitochondrial gene for subunit I of cytochrome oxidase."
    Bonen L., Boer P.H., McIntosh J.E., Gray M.W.
    Nucleic Acids Res. 15:6734-6734(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Thatcher.
  2. "A chimeric open reading frame in the 5' flanking region of coxI mitochondrial DNA from cytoplasmic male-sterile wheat."
    Rathburn H.B., Hedgcoth C.
    Plant Mol. Biol. 16:909-912(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_WHEAT
AccessioniPrimary (citable) accession number: P68539
Secondary accession number(s): P08741
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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