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P68530

- COX2_BOVIN

UniProt

P68530 - COX2_BOVIN

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Protein
Cytochrome c oxidase subunit 2
Gene
MT-CO2, COII, COXII, MTCO2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Copper A1
Metal bindingi196 – 1961Copper A1
Metal bindingi196 – 1961Copper A2
Metal bindingi198 – 1981Copper A2; via carbonyl oxygen
Metal bindingi198 – 1981Magnesium; shared with chain I
Metal bindingi200 – 2001Copper A1
Metal bindingi200 – 2001Copper A2
Metal bindingi204 – 2041Copper A2
Metal bindingi207 – 2071Copper A1

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: InterPro

GO - Biological processi

  1. electron transport chain Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Protein family/group databases

TCDBi3.D.4.7.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded oniMitochondrion
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414Mitochondrial intermembrane
Add
BLAST
Transmembranei15 – 4531Helical; Name=I
Add
BLAST
Topological domaini46 – 5914Mitochondrial matrix
Add
BLAST
Transmembranei60 – 8728Helical; Name=II
Add
BLAST
Topological domaini88 – 227140Mitochondrial intermembrane
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Cytochrome c oxidase subunit 2
PRO_0000183517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-formylmethionine

Keywords - PTMi

Formylation

Proteomic databases

PaxDbiP68530.
PRIDEiP68530.

Interactioni

Protein-protein interaction databases

IntActiP68530. 1 interaction.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 4632
Helixi61 – 8828
Beta strandi94 – 1029
Beta strandi105 – 1106
Beta strandi112 – 1143
Beta strandi116 – 1205
Helixi125 – 1273
Turni134 – 1363
Beta strandi138 – 1403
Beta strandi142 – 1454
Beta strandi150 – 15910
Beta strandi161 – 1655
Helixi166 – 1683
Beta strandi170 – 1745
Beta strandi180 – 1845
Beta strandi190 – 1945
Helixi204 – 2063
Beta strandi209 – 2146
Helixi216 – 22510

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80B/O1-227[»]
1OCOX-ray2.80B/O1-227[»]
1OCRX-ray2.35B/O1-227[»]
1OCZX-ray2.90B/O1-227[»]
1V54X-ray1.80B/O1-227[»]
1V55X-ray1.90B/O1-227[»]
2DYRX-ray1.80B/O1-227[»]
2DYSX-ray2.20B/O1-227[»]
2EIJX-ray1.90B/O1-227[»]
2EIKX-ray2.10B/O1-227[»]
2EILX-ray2.10B/O1-227[»]
2EIMX-ray2.60B/O1-227[»]
2EINX-ray2.70B/O1-227[»]
2OCCX-ray2.30B/O1-227[»]
2Y69X-ray1.95B/O1-227[»]
2YBBelectron microscopy19.00M1-227[»]
2ZXWX-ray2.50B/O1-227[»]
3ABKX-ray2.00B/O1-227[»]
3ABLX-ray2.10B/O1-227[»]
3ABMX-ray1.95B/O1-227[»]
3AG1X-ray2.20B/O1-227[»]
3AG2X-ray1.80B/O1-227[»]
3AG3X-ray1.80B/O1-227[»]
3AG4X-ray2.05B/O1-227[»]
3ASNX-ray3.00B/O1-227[»]
3ASOX-ray2.30B/O1-227[»]
3WG7X-ray1.90B/O1-227[»]
ProteinModelPortaliP68530.
SMRiP68530. Positions 1-227.

Miscellaneous databases

EvolutionaryTraceiP68530.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000264988.
HOVERGENiHBG012727.
InParanoidiP68530.
KOiK02261.
OMAiDHALMIV.
OrthoDBiEOG7TJ3JX.
TreeFamiTF344269.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P68530-1 [UniParc]FASTAAdd to Basket

« Hide

MAYPMQLGFQ DATSPIMEEL LHFHDHTLMI VFLISSLVLY IISLMLTTKL    50
THTSTMDAQE VETIWTILPA IILILIALPS LRILYMMDEI NNPSLTVKTM 100
GHQWYWSYEY TDYEDLSFDS YMIPTSELKP GELRLLEVDN RVVLPMEMTI 150
RMLVSSEDVL HSWAVPSLGL KTDAIPGRLN QTTLMSSRPG LYYGQCSEIC 200
GSNHSFMPIV LELVPLKYFE KWSASML 227
Length:227
Mass (Da):26,021
Last modified:July 21, 1986 - v1
Checksum:iC562D5B39FA9771A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581A → P in AAA31644. 1 Publication
Sequence conflicti118 – 1181F → L in AAA31644. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00654 Genomic DNA. Translation: CAA24000.1.
M10544 Genomic DNA. Translation: AAA31644.1.
AF490528 Genomic DNA. Translation: AAM08331.1.
AF490529 Genomic DNA. Translation: AAM08344.1.
AF493541 Genomic DNA. Translation: AAM12792.1.
AF493542 Genomic DNA. Translation: AAM12805.1.
PIRiB00152. OBBO2.
RefSeqiYP_209208.1. NC_006853.1.

Genome annotation databases

EnsembliENSBTAT00000060549; ENSBTAP00000053151; ENSBTAG00000043556.
GeneIDi3283880.
KEGGibta:3283880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00654 Genomic DNA. Translation: CAA24000.1 .
M10544 Genomic DNA. Translation: AAA31644.1 .
AF490528 Genomic DNA. Translation: AAM08331.1 .
AF490529 Genomic DNA. Translation: AAM08344.1 .
AF493541 Genomic DNA. Translation: AAM12792.1 .
AF493542 Genomic DNA. Translation: AAM12805.1 .
PIRi B00152. OBBO2.
RefSeqi YP_209208.1. NC_006853.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCC X-ray 2.80 B/O 1-227 [» ]
1OCO X-ray 2.80 B/O 1-227 [» ]
1OCR X-ray 2.35 B/O 1-227 [» ]
1OCZ X-ray 2.90 B/O 1-227 [» ]
1V54 X-ray 1.80 B/O 1-227 [» ]
1V55 X-ray 1.90 B/O 1-227 [» ]
2DYR X-ray 1.80 B/O 1-227 [» ]
2DYS X-ray 2.20 B/O 1-227 [» ]
2EIJ X-ray 1.90 B/O 1-227 [» ]
2EIK X-ray 2.10 B/O 1-227 [» ]
2EIL X-ray 2.10 B/O 1-227 [» ]
2EIM X-ray 2.60 B/O 1-227 [» ]
2EIN X-ray 2.70 B/O 1-227 [» ]
2OCC X-ray 2.30 B/O 1-227 [» ]
2Y69 X-ray 1.95 B/O 1-227 [» ]
2YBB electron microscopy 19.00 M 1-227 [» ]
2ZXW X-ray 2.50 B/O 1-227 [» ]
3ABK X-ray 2.00 B/O 1-227 [» ]
3ABL X-ray 2.10 B/O 1-227 [» ]
3ABM X-ray 1.95 B/O 1-227 [» ]
3AG1 X-ray 2.20 B/O 1-227 [» ]
3AG2 X-ray 1.80 B/O 1-227 [» ]
3AG3 X-ray 1.80 B/O 1-227 [» ]
3AG4 X-ray 2.05 B/O 1-227 [» ]
3ASN X-ray 3.00 B/O 1-227 [» ]
3ASO X-ray 2.30 B/O 1-227 [» ]
3WG7 X-ray 1.90 B/O 1-227 [» ]
ProteinModelPortali P68530.
SMRi P68530. Positions 1-227.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P68530. 1 interaction.

Protein family/group databases

TCDBi 3.D.4.7.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

PaxDbi P68530.
PRIDEi P68530.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000060549 ; ENSBTAP00000053151 ; ENSBTAG00000043556 .
GeneIDi 3283880.
KEGGi bta:3283880.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

eggNOGi COG1622.
HOGENOMi HOG000264988.
HOVERGENi HBG012727.
InParanoidi P68530.
KOi K02261.
OMAi DHALMIV.
OrthoDBi EOG7TJ3JX.
TreeFami TF344269.

Miscellaneous databases

EvolutionaryTracei P68530.
NextBioi 20810187.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Studies on cytochrome c oxidase, IV[1-3]. Primary structure and function of subunit II."
    Steffens G.J., Buse G.
    Hoppe-Seyler's Z. Physiol. Chem. 360:613-619(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FORMYLATION AT MET-1.
    Tissue: Heart.
  2. "Complete sequence of bovine mitochondrial DNA. Conserved features of the mammalian mitochondrial genome."
    Anderson S., de Bruijn M.H.L., Coulson A.R., Eperon I.C., Sanger F., Young I.G.
    J. Mol. Biol. 156:683-717(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Heart.
  3. "The genetic code in bovine mitochondria: sequence of genes for the cytochrome oxidase subunit II and two tRNAs."
    Young I.G., Anderson S.
    Gene 12:257-265(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Bos taurus mitochondrial protein coding regions."
    Wettstein P.J.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 65, 66, D and F.
  5. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  7. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCOX2_BOVIN
AccessioniPrimary (citable) accession number: P68530
Secondary accession number(s): P00404
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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