Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P68510

- 1433F_MOUSE

UniProt

P68510 - 1433F_MOUSE

Protein

14-3-3 protein eta

Gene

Ywhah

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei57 – 571Interaction with phosphoserine on interacting proteinBy similarity
    Sitei132 – 1321Interaction with phosphoserine on interacting proteinBy similarity

    GO - Molecular functioni

    1. actin binding Source: ProtInc
    2. glucocorticoid receptor binding Source: UniProtKB
    3. ion channel binding Source: BHF-UCL
    4. protein binding Source: IntAct
    5. protein domain specific binding Source: MGI
    6. sodium channel regulator activity Source: BHF-UCL

    GO - Biological processi

    1. cytoskeleton organization Source: ProtInc
    2. glucocorticoid catabolic process Source: UniProtKB
    3. glucocorticoid receptor signaling pathway Source: UniProtKB
    4. intracellular protein transport Source: MGI
    5. membrane depolarization during action potential Source: BHF-UCL
    6. negative regulation of apoptotic process Source: ProtInc
    7. negative regulation of dendrite morphogenesis Source: MGI
    8. positive regulation of transcription, DNA-templated Source: UniProtKB
    9. regulation of mitosis Source: ProtInc
    10. regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
    11. regulation of sodium ion transport Source: BHF-UCL

    Enzyme and pathway databases

    ReactomeiREACT_199054. Translocation of GLUT4 to the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    14-3-3 protein eta
    Gene namesi
    Name:Ywhah
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:109194. Ywhah.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytoplasmic vesicle membrane Source: Reactome
    3. cytosol Source: Reactome
    4. extracellular vesicular exosome Source: Ensembl
    5. intercalated disc Source: BHF-UCL
    6. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 24624514-3-3 protein etaPRO_0000058624Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycineBy similarity
    Modified residuei25 – 251PhosphoserineBy similarity
    Modified residuei59 – 591Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP68510.
    PaxDbiP68510.
    PRIDEiP68510.

    2D gel databases

    UCD-2DPAGEP68510.

    PTM databases

    PhosphoSiteiP68510.

    Expressioni

    Gene expression databases

    BgeeiP68510.
    GenevestigatoriP68510.

    Interactioni

    Subunit structurei

    Homodimer By similarity. Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Weakly interacts with CDKN1B By similarity. Interacts with ARHGEF28 and CDK16. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1. Interacts with the 'Ser-241' phosphorylated form of PDPK1 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Lrrk2Q5S0064EBI-444641,EBI-2693710
    Park2Q9WVS68EBI-444641,EBI-973635
    SncaO550422EBI-444641,EBI-2310271
    TNFAIP3P215803EBI-444641,EBI-527670From a different organism.

    Protein-protein interaction databases

    BioGridi204621. 7 interactions.
    IntActiP68510. 315 interactions.
    MINTiMINT-198030.

    Structurei

    3D structure databases

    ProteinModelPortaliP68510.
    SMRiP68510. Positions 2-236.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 14-3-3 family.Curated

    Phylogenomic databases

    eggNOGiCOG5040.
    GeneTreeiENSGT00730000110613.
    HOGENOMiHOG000240379.
    HOVERGENiHBG050423.
    InParanoidiP68510.
    KOiK16198.
    OMAiESSEAAY.
    OrthoDBiEOG7HHWT3.
    PhylomeDBiP68510.
    TreeFamiTF102003.

    Family and domain databases

    Gene3Di1.20.190.20. 1 hit.
    InterProiIPR000308. 14-3-3.
    IPR023409. 14-3-3_CS.
    IPR023410. 14-3-3_domain.
    [Graphical view]
    PANTHERiPTHR18860. PTHR18860. 1 hit.
    PfamiPF00244. 14-3-3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000868. 14-3-3. 1 hit.
    PRINTSiPR00305. 1433ZETA.
    SMARTiSM00101. 14_3_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48445. SSF48445. 1 hit.
    PROSITEiPS00796. 1433_1. 1 hit.
    PS00797. 1433_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P68510-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDREQLLQR ARLAEQAERY DDMASAMKAV TELNEPLSNE DRNLLSVAYK    50
    NVVGARRSSW RVISSIEQKT MADGNEKKLE KVKAYREKIE KELETVCNDV 100
    LALLDKFLIK NCNDFQYESK VFYLKMKGDY YRYLAEVASG EKKNSVVEAS 150
    EAAYKEAFEI SKEHMQPTHP IRLGLALNFS VFYYEIQNAP EQACLLAKQA 200
    FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE EAGEGN 246
    Length:246
    Mass (Da):28,212
    Last modified:January 23, 2007 - v2
    Checksum:iC12F62B4ABA76DA3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 162EQ → DE in BAA13422. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57311 mRNA. Translation: AAC53256.1.
    D87661 mRNA. Translation: BAA13422.1.
    AF077002 mRNA. Translation: AAC36290.1.
    AB063572 Genomic DNA. Translation: BAB79599.1.
    AK077596 mRNA. Translation: BAC36887.1.
    AK149224 mRNA. Translation: BAE28768.1.
    AK168520 mRNA. Translation: BAE40399.1.
    AK169035 mRNA. Translation: BAE40826.1.
    AK169189 mRNA. Translation: BAE40965.1.
    BC008187 mRNA. Translation: AAH08187.1.
    BC061497 mRNA. Translation: AAH61497.1.
    CCDSiCCDS19198.1.
    RefSeqiNP_035868.1. NM_011738.2.
    UniGeneiMm.332314.

    Genome annotation databases

    EnsembliENSMUST00000019109; ENSMUSP00000019109; ENSMUSG00000018965.
    GeneIDi22629.
    KEGGimmu:22629.
    UCSCiuc008xag.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57311 mRNA. Translation: AAC53256.1 .
    D87661 mRNA. Translation: BAA13422.1 .
    AF077002 mRNA. Translation: AAC36290.1 .
    AB063572 Genomic DNA. Translation: BAB79599.1 .
    AK077596 mRNA. Translation: BAC36887.1 .
    AK149224 mRNA. Translation: BAE28768.1 .
    AK168520 mRNA. Translation: BAE40399.1 .
    AK169035 mRNA. Translation: BAE40826.1 .
    AK169189 mRNA. Translation: BAE40965.1 .
    BC008187 mRNA. Translation: AAH08187.1 .
    BC061497 mRNA. Translation: AAH61497.1 .
    CCDSi CCDS19198.1.
    RefSeqi NP_035868.1. NM_011738.2.
    UniGenei Mm.332314.

    3D structure databases

    ProteinModelPortali P68510.
    SMRi P68510. Positions 2-236.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204621. 7 interactions.
    IntActi P68510. 315 interactions.
    MINTi MINT-198030.

    PTM databases

    PhosphoSitei P68510.

    2D gel databases

    UCD-2DPAGE P68510.

    Proteomic databases

    MaxQBi P68510.
    PaxDbi P68510.
    PRIDEi P68510.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019109 ; ENSMUSP00000019109 ; ENSMUSG00000018965 .
    GeneIDi 22629.
    KEGGi mmu:22629.
    UCSCi uc008xag.2. mouse.

    Organism-specific databases

    CTDi 7533.
    MGIi MGI:109194. Ywhah.

    Phylogenomic databases

    eggNOGi COG5040.
    GeneTreei ENSGT00730000110613.
    HOGENOMi HOG000240379.
    HOVERGENi HBG050423.
    InParanoidi P68510.
    KOi K16198.
    OMAi ESSEAAY.
    OrthoDBi EOG7HHWT3.
    PhylomeDBi P68510.
    TreeFami TF102003.

    Enzyme and pathway databases

    Reactomei REACT_199054. Translocation of GLUT4 to the plasma membrane.

    Miscellaneous databases

    NextBioi 302995.
    PROi P68510.
    SOURCEi Search...

    Gene expression databases

    Bgeei P68510.
    Genevestigatori P68510.

    Family and domain databases

    Gene3Di 1.20.190.20. 1 hit.
    InterProi IPR000308. 14-3-3.
    IPR023409. 14-3-3_CS.
    IPR023410. 14-3-3_domain.
    [Graphical view ]
    PANTHERi PTHR18860. PTHR18860. 1 hit.
    Pfami PF00244. 14-3-3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000868. 14-3-3. 1 hit.
    PRINTSi PR00305. 1433ZETA.
    SMARTi SM00101. 14_3_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48445. SSF48445. 1 hit.
    PROSITEi PS00796. 1433_1. 1 hit.
    PS00797. 1433_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins."
      Sladeczek F., Camonis J.H., Burnol A.-F., Le Bouffant F.
      Mol. Gen. Genet. 254:571-577(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CDK16.
      Tissue: Brain.
    2. Takihara Y., Irie K., Nomura M., Motaleb M., Matsumoto K., Shimada K.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
    3. "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins."
      Tang S.J., Seun T.-C., McInnes R.R., Buchwald M.
      J. Biol. Chem. 273:25356-25363(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Isolation and structure of the mouse 14-3-3 eta chain gene and the distribution of 14-3-3 eta mRNA in the mouse brain."
      Toyooka K., Muratake T., Watanabe H., Hayashi S., Ichikawa T., Usui H., Washiyama K., Kumanishi T., Takahashi Y.
      Brain Res. Mol. Brain Res. 100:13-20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart, Kidney and Sympathetic ganglion.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    7. Lubec G., Kang S.U., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 13-56; 62-69; 92-106; 111-120; 133-172 AND 199-227, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6 and OF1.
      Tissue: Brain and Hippocampus.
    8. "A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein."
      Megidish T., Cooper J., Zhang L., Fu H., Hakomori S.
      J. Biol. Chem. 273:21834-21845(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-59.
    9. "Identification of a novel interaction of 14-3-3 with p190RhoGEF."
      Zhai J., Lin H., Shamim M., Schlaepfer W.W., Canete-Soler R.
      J. Biol. Chem. 276:41318-41324(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARHGEF28.
    10. "Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation."
      Czirjak G., Vuity D., Enyedi P.
      J. Biol. Chem. 283:15672-15680(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KCNK18.
    11. Cited for: INTERACTION WITH SAMSN1.

    Entry informationi

    Entry namei1433F_MOUSE
    AccessioniPrimary (citable) accession number: P68510
    Secondary accession number(s): P11576, P70198, Q3TGZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3